公开(公告)号：US20230357417A1

公开(公告)日：2023-11-09

申请号：US18180704

申请日：2023-03-08

Applicant: Pfizer Inc.

Inventor： Manoj Baburao CHARATI ,  Yoon-Chi HAN ,  Madan KATRAGADDA ,  Nicole Melissa PICHÉ-NICHOLAS ,  Lawrence Nathan TUMEY

IPC: C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C12N15/63

CPC classification number: C07K16/2866 ,  A61K47/6851 ,  A61K47/6803 ,  A61P35/00 ,  C12N15/63 ,  A61K2039/505

Abstract: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease).

公开(公告)号：US20200283536A1

公开(公告)日：2020-09-10

申请号：US16758124

申请日：2018-10-16

Applicant: Pfizer Inc.

Inventor： Manoj Baburao CHARATI ,  Yoon-Chi HAN ,  Madan KATRAGADDA ,  Nicole Melissa PICHÉ-NICHOLAS ,  Lawrence Nathan TUMEY

IPC: C07K16/28 ,  A61K47/68 ,  C12N15/63 ,  A61P35/00

Abstract: The present invention provides antibodies that specifically bind to CD123. The invention further relates to immunoconjugates (e.g., antibody-drug conjugates, or ADCs) comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and ADCs for the treatment of a condition associated with cells expressing CD123 (e.g., cancer or autoimmune disease).

公开(公告)号：US20200069764A1

公开(公告)日：2020-03-05

申请号：US16688173

申请日：2019-11-19

Applicant: Pfizer Inc.

Inventor： Dangshe MA ,  Kimberly Ann MARQUETTE ,  Edmund Idris GRAZIANI ,  Puja SAPRA ,  Lawrence Nathan TUMEY ,  Nadira Anarkali PRASHAD ,  Kiran Manohar KHANDKE ,  Eric M. BENNETT ,  Lioudmila TCHISTIAKOVA

IPC: A61K38/05 ,  C07K16/28 ,  C07K16/32 ,  A61K47/68

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.

公开(公告)号：US20170216452A1

公开(公告)日：2017-08-03

申请号：US15356953

申请日：2016-11-21

Applicant: Pfizer Inc.

Inventor： Dangshe MA ,  Kimberly Ann MARQUETTE ,  Edmund Idris GRAZIANI ,  Puja SAPRA ,  Lawrence Nathan TUMEY ,  Nadira Anarkali PRASHAD ,  Kiran Manohar KHANDKE ,  Eric M. BENNETT ,  Lioudmila TCHISTIAKOVA

IPC: A61K51/10 ,  C07K16/28 ,  C07K16/32 ,  A61K38/05 ,  C07K19/00 ,  A61K48/00 ,  A61K47/48

CPC classification number: A61K38/05 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  C07K16/283 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to polypeptides, antibodies, and antigen-binding fragments thereof, that comprise a substituted cysteine for site-specific conjugation.