公开(公告)号：US20240366598A1

公开(公告)日：2024-11-07

申请号：US18634154

申请日：2024-04-12

Applicant: Pfizer Inc.

Inventor： Kevin James Filipski ,  Matthew Forrest Sammons ,  Samuel Michael Levi ,  Yang Wang ,  Advaita Panchagnula ,  Yanfei Guan ,  Matthew Richard Reese ,  Luis Angel Martinez Alsina ,  Steven Victor O'Neil ,  Lei Zhang ,  Qifang Li ,  Ethan Lawrence Fisher ,  Danica Antonia Rankic

IPC: A61K31/506 ,  A61K31/403 ,  A61K31/4439 ,  A61K31/444 ,  A61P3/04 ,  C07D207/16 ,  C07D209/52 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

Abstract: Described herein are compounds of Formula I: and their pharmaceutically acceptable salts, wherein R1, R2, R3, L1, T1, T2, T3, T4, t1, and t2 are defined herein; their use as GIPR antagonists; pharmaceutical compositions containing such compounds and salts; and the use of such compounds and salts to treat or prevent, for example, obesity, weight gain, and/or T2DM.

公开(公告)号：US11339159B2

公开(公告)日：2022-05-24

申请号：US16926933

申请日：2020-07-13

Applicant: Pfizer Inc.

Inventor： Omar Ahmad ,  Andrew Fensome ,  Erik Alphie LaChapelle ,  Ethan Lawrence Fisher ,  Rayomand J. Unwalla ,  Jun Xiao ,  Lei Zhang

IPC: C07D471/04 ,  A61K31/437

Abstract: The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

公开(公告)号：US20220274986A1

公开(公告)日：2022-09-01

申请号：US17738074

申请日：2022-05-06

Applicant: Pfizer Inc.

Inventor： Omar Ahmad ,  Andrew Fensome ,  Erik Alphie LaChapelle ,  Ethan Lawrence Fisher ,  Rayomand J. Unwalla ,  Jun Xiao ,  Lei Zhang

IPC: C07D471/04 ,  A61K31/437

Abstract: The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

公开(公告)号：US20210017172A1

公开(公告)日：2021-01-21

申请号：US16926933

申请日：2020-07-13

Applicant: Pfizer Inc.

Inventor： Omar Ahmad ,  Andrew Fensome ,  Erik Alphie LaChapelle ,  Ethan Lawrence Fisher ,  Rayomand J. Unwalla ,  Jun Xiao ,  Lei Zhang

IPC: C07D471/04 ,  A61K31/437

Abstract: The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.

公开(公告)号：US12297190B2

公开(公告)日：2025-05-13

申请号：US17029557

申请日：2020-09-23

Applicant: PFIZER INC.

Inventor： Ryan Patman ,  Martin James Wythes ,  Eugene Yuanjin Rui ,  Indrawan James McAlpine ,  Andrew Fensome ,  Mehran Jalaie ,  Ketan S. Gajiwala ,  Chan Woo Huh ,  Tuan Phong Tran ,  Lei Zhang ,  Dahui Zhou ,  Ethan Lawrence Fisher

IPC: C07D403/14 ,  A61K31/4196 ,  A61K31/424 ,  A61K31/427 ,  A61K31/437 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/5386 ,  A61K38/21 ,  A61K39/395 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/06 ,  C07D491/08 ,  C07D491/107 ,  C07D498/04 ,  C07D498/08

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US11976064B2

公开(公告)日：2024-05-07

申请号：US17738074

申请日：2022-05-06

Applicant: Pfizer Inc.

Inventor： Omar Ahmad ,  Andrew Fensome ,  Erik Alphie LaChapelle ,  Ethan Lawrence Fisher ,  Rayomand J. Unwalla ,  Jun Xiao ,  Lei Zhang

IPC: A61K31/4745 ,  A61K31/437 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/437

Abstract: The present invention relates to imidazo-pyridinyl compounds, or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject.