公开(公告)号：US20160221989A1

公开(公告)日：2016-08-04

申请号：US14817416

申请日：2015-08-04

Applicant: Pfizer Inc.

Inventor： Sharanjeet Kaur Bagal ,  Kiyoyuki Omoto ,  Sarah Elizabeth Skerratt ,  Jingrong Jean Cui ,  Samantha Elizabeth Greasley ,  Indrawan James McAlpine ,  Asako Nagata ,  Sacha Ninkovic ,  Michelle Bich Tran-Dubé

IPC: C07D401/12 ,  A61K31/4439

CPC classification number: C07D401/12 ,  A61K31/4439

Abstract: The present invention relates to compounds of Formula I described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.

Abstract translation: 本发明涉及本文所述的式I化合物及其药学上可接受的盐，以及它们在医药中的用途，特别是作为Trk拮抗剂。

公开(公告)号：US20220251075A1

公开(公告)日：2022-08-11

申请号：US17620188

申请日：2020-06-17

Applicant: Pfizer Inc. ,  CTXT PTY LTD

Inventor： Oleg Brodsky ,  Samantha Elizabeth Greasley ,  Robert Louis Hoffman ,  Pei-Pei Kung ,  Paul Francis Richardson ,  Paul Anthony Stupple

IPC: C07D413/14 ,  C07D413/06

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, Y, R1-R8, m, n and p are defined herein. The novel cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

公开(公告)号：US20230174522A1

公开(公告)日：2023-06-08

申请号：US17946101

申请日：2022-09-16

Applicant: Pfizer Inc. ,  CTXT PTY LTD

Inventor： Ylva Elisabet Bergman Bozikis ,  Oleg Brodsky ,  Michelle Ang Camerino ,  Samantha Elizabeth Greasley ,  Robert Louis Hoffman ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Paul Francis Richardson ,  Paul Anthony Stupple ,  Scott Channing Sutton

IPC: C07D413/06 ,  A61P35/04

CPC classification number: C07D413/06 ,  A61P35/04 ,  A61K45/06

Abstract: The present invention relates to compounds of formula (I)




or pharmaceutically acceptable salts thereof, wherein Ring A, R1-R8, and n are defined herein. The novel benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

公开(公告)号：US10125130B2

公开(公告)日：2018-11-13

申请号：US15826027

申请日：2017-11-29

Applicant: PFIZER INC.

Inventor： Aaron Craig Burns ,  Michael Raymond Collins ,  Samantha Elizabeth Greasley ,  Robert Louis Hoffman ,  Peter Qinhua Huang ,  Robert Steven Kania ,  Pei-Pei Kung ,  Maria Angelica Linton ,  Lakshmi Sourirajan Narasimhan ,  Paul Francis Richardson ,  Daniel Tyler Richter ,  Graham Smith

IPC: C07D417/14 ,  C07D417/08 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D277/46 ,  C07D401/14

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

公开(公告)号：US10676471B2

公开(公告)日：2020-06-09

申请号：US16416997

申请日：2019-05-20

Applicant: Pfizer Inc.

Inventor： Aaron Craig Burns ,  Michael Raymond Collins ,  Samantha Elizabeth Greasley ,  Robert Louis Hoffman ,  Peter Qinhua Huang ,  Robert Steven Kania ,  Pei-Pei Kung ,  Maria Angelica Linton ,  Lakshmi Sourirajan Narasimhan ,  Paul Francis Richardson ,  Daniel Tyler Richter ,  Graham Smith

IPC: C07D417/14 ,  C07D401/14 ,  C07D417/08 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D277/46

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

公开(公告)号：US20190270737A1

公开(公告)日：2019-09-05

申请号：US16416997

申请日：2019-05-20

Applicant: Pfizer Inc.

Inventor： Aaron Craig Burns ,  Michael Raymond Collins ,  Samantha Elizabeth Greasley ,  Robert Louis Hoffman ,  Peter Qinhua Huang ,  Robert Steven Kania ,  Pei-Pei Kung ,  Maria Angelica Linton ,  Lakshmi Sourirajan Narasimhan ,  Paul Francis Richardson ,  Daniel Tyler Richter ,  Graham Smith

IPC: C07D417/14 ,  C07D417/08

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

公开(公告)号：US20190040055A1

公开(公告)日：2019-02-07

申请号：US16157618

申请日：2018-10-11

Applicant: Pfizer Inc.

Inventor： Aaron Craig Burns ,  Michael Raymond Collins ,  Samantha Elizabeth Greasley ,  Robert Louis Hoffman ,  Peter Qinhua Huang ,  Robert Steven Kania ,  Pei-Pei Kung ,  Maria Angelica Linton ,  Lakshmi Sourirajan Narasimhan ,  Paul Francis Richardson ,  Daniel Tyler Richter ,  Graham Smith

IPC: C07D417/14 ,  C07D417/08 ,  C07D277/46 ,  A61K45/06 ,  A61K31/427 ,  A61K31/501 ,  A61K31/444 ,  A61K31/4439 ,  C07D401/14 ,  A61K31/506

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.

公开(公告)号：US20170197939A1

公开(公告)日：2017-07-13

申请号：US15300440

申请日：2015-04-01

Applicant: PFIZER INC.

Inventor： Sharanjeet Kaur Bagal ,  Jingrong Jean Cui ,  Samantha Elizabeth Greasley ,  Elizabeth Ann Lunney ,  Indrawan James McAlpine ,  Asako Nagata ,  Sacha Ninkovic ,  Kiyoyuki Omoto ,  Sarah Elizabeth Skerratt ,  Robert Ian Storer ,  Joseph Scott Warmus

IPC: C07D401/14 ,  A61K31/4439 ,  C07D401/12

CPC classification number: C07D401/14 ,  A61K31/4439 ,  C07D401/12

Abstract: The present invention relates to compounds of Formula I and their prodrugs and pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

公开(公告)号：US09328096B2

公开(公告)日：2016-05-03

申请号：US14705272

申请日：2015-05-06

Applicant: PFIZER INC

Inventor： Sharanjeet Kaur Bagal ,  Jingrong Jean Cui ,  Samantha Elizabeth Greasley ,  Elizabeth Ann Lunney ,  Indrawan James McAlpine ,  Asako Nagata ,  Sacha Ninkovic ,  Kiyoyuki Omoto ,  Sarah Elizabeth Skerratt ,  Robert Ian Storer ,  Joseph Scott Warmus

IPC: A61P35/00 ,  C07D413/14 ,  A61P29/00 ,  C07D405/14 ,  A61K31/4439 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D413/14

Abstract: The present invention relates to compounds of Formula I and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as TrkA antagonists.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐，其中取代基如本文所述，及其在药物中的用途，特别是作为TrkA拮抗剂。