公开(公告)号：US20240025950A1

公开(公告)日：2024-01-25

申请号：US18031036

申请日：2021-07-22

Applicant: Pfizer Inc.

Inventor： Ping Cai ,  Eun Hee Koh ,  Eugene Joseph Vidunas ,  Michele L. Weaver ,  Xinhao Ye ,  Yonghui Yuan ,  Jay Zhixing Zhao

IPC: C07K14/005

CPC classification number: C07K14/005 ,  C12N2760/18522 ,  C12N2760/18551 ,  A61K38/00

Abstract: The invention relates to a purification method of a recombinantly-produced RSV F protein in trimeric form. According to the invention, the method sequentially comprises an anion exchange chromatography step, a cHA chromatography step and a HIC step. The invention is also directed to a pharmaceutical product including an RSV F protein purified by such a method.