公开(公告)号：US09802987B2

公开(公告)日：2017-10-31

申请号：US14773324

申请日：2014-03-05

Applicant: PFIZER INC.

Inventor： Deborah Ann Dilts ,  Annaliesa Sybil Anderson ,  Kathrin Ute Jansen ,  Justin Keith Moran ,  Mark E Ruppen ,  Eugene Joseph Vidunas

IPC: A61K39/00 ,  A61K39/02 ,  A61K39/38 ,  A61K39/385 ,  C07K14/22 ,  A61K39/095 ,  C07K14/315 ,  A61K39/09

CPC classification number: C07K14/22 ,  A61K39/092 ,  A61K39/095 ,  A61K2039/6037 ,  A61K2039/6068 ,  C07K14/3156 ,  C07K2319/00 ,  C07K2319/55

Abstract: In one aspect, the invention relates to an isolated polypeptide including the amino acid sequence of a carrier polypeptide and the amino acid sequence of an ORF2086 polypeptide. In another aspect, the invention relates to an immunogenic conjugate including ORF2086 polypeptide and a carrier polypeptide. The invention further includes immunogenic compositions and methods for inducing an immune response against Neisseria meningitidis in a mammal.

公开(公告)号：US20240025950A1

公开(公告)日：2024-01-25

申请号：US18031036

申请日：2021-07-22

Applicant: Pfizer Inc.

Inventor： Ping Cai ,  Eun Hee Koh ,  Eugene Joseph Vidunas ,  Michele L. Weaver ,  Xinhao Ye ,  Yonghui Yuan ,  Jay Zhixing Zhao

IPC: C07K14/005

CPC classification number: C07K14/005 ,  C12N2760/18522 ,  C12N2760/18551 ,  A61K38/00

Abstract: The invention relates to a purification method of a recombinantly-produced RSV F protein in trimeric form. According to the invention, the method sequentially comprises an anion exchange chromatography step, a cHA chromatography step and a HIC step. The invention is also directed to a pharmaceutical product including an RSV F protein purified by such a method.

公开(公告)号：US20160017006A1

公开(公告)日：2016-01-21

申请号：US14773324

申请日：2014-03-05

Applicant: PFIZER INC.

Inventor： Deborah Ann Dilts ,  Annaliesa Sybil Anderson ,  Kathrin Ute Jansen ,  Justin Keith Moran ,  Mark E Ruppen ,  Eugene Joseph Vidunas

IPC: C07K14/22 ,  A61K39/095 ,  A61K39/09 ,  C07K14/315

CPC classification number: C07K14/22 ,  A61K39/092 ,  A61K39/095 ,  A61K2039/6037 ,  A61K2039/6068 ,  C07K14/3156 ,  C07K2319/00 ,  C07K2319/55

Abstract: In one aspect, the invention relates to an isolated polypeptide including the amino acid sequence of a carrier polypeptide and the amino acid sequence of an ORF2086 polypeptide. In another aspect, the invention relates to an immunogenic conjugate including ORF2086 polypeptide and a carrier polypeptide. The invention further includes immunogenic compositions and methods for inducing an immune response against Neisseria meningitidis in a mammal.

Abstract translation: 一方面，本发明涉及包含载体多肽的氨基酸序列和ORF2086多肽的氨基酸序列的分离的多肽。 另一方面，本发明涉及包含ORF2086多肽和载体多肽的免疫原性缀合物。 本发明还包括用于在哺乳动物中诱导针对脑膜炎奈瑟氏球菌的免疫应答的免疫原性组合物和方法。