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公开(公告)号：US20210188991A1
公开(公告)日：2021-06-24
申请号：US17129833
申请日：2020-12-21
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K39/395 , A61K31/454 , A61K31/704 , A61K31/69 , A61K47/68
Abstract: The present invention relates bispecific antibodies that specific binds to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3). Method of making the bispecific antibodies and method of using the bispecific antibodies for the treatment of multiple myeloma are also provided.
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公开(公告)号：US20180171018A1
公开(公告)日：2018-06-21
申请号：US15878344
申请日：2018-01-23
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K39/395 , A61K47/68 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/00
CPC classification number: C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K2300/00
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US20230181634A1
公开(公告)日：2023-06-15
申请号：US16617487
申请日：2018-05-31
Applicant: Pfizer Inc.
Inventor： Barbra Johnson SASU , Danielle Elizabeth DETTLING , Cesar Adolfo SOMMER , Yik Andy YEUNG , Moustafa Marc HAMZE
IPC: A61K35/17 , C07K14/725 , C07K16/28 , C07K14/705 , C07K14/715 , A61K39/395 , A61K45/06 , A61P35/02
CPC classification number: A61K35/17 , C07K14/7051 , C07K16/2863 , C07K14/70517 , C07K14/7151 , A61K39/3955 , A61K45/06 , A61P35/02 , C07K2317/622 , A61K38/00
Abstract: Provided herein are antibodies that specifically bind to Fms-like tyrosine kinase 3 (FLT3), chimeric antigen receptors (CARs) that specifically bind to FLT3, and engineered immune cells expressing such CARs (e.g. FLT3-specific CAR-T cells). The invention also provides making such antibodies, CARs, and engineered immune cells. The invention also provides using such antibodies, CARs, and engineered immune cells, for example for the treatment of a condition associated with malignant cells expressing FLT3 (e.g., cancer).
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公开(公告)号：US20210054087A1
公开(公告)日：2021-02-25
申请号：US17005073
申请日：2020-08-27
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K39/395 , A61K31/454 , A61K31/704 , A61K31/69 , A61K47/68
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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Patent Agency Ranking
公开(公告)号：US20160297885A1
公开(公告)日：2016-10-13
申请号：US15085644
申请日：2016-03-30
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K31/704 , A61K38/07 , A61K38/05 , A61K39/395 , A61K31/454
CPC classification number: C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K2300/00
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
Abstract translation: 本发明涉及特异性结合BCMA（B细胞成熟抗原）和/或CD3（分化群3）的抗体，例如全长抗体或其抗原结合片段。 本发明还涉及包含BCMA抗体的抗体缀合物（例如，抗体 - 药物偶联物），包含BCMA抗体的组合物，以及使用BCMA抗体及其缀合物治疗与表达BCMA的细胞相关的病症的方法（例如癌症或 自身免疫性疾病）。 本发明还涉及特异性结合CD3和肿瘤细胞抗原的异源多聚体抗体（例如，特异性结合CD3和BCMA的双特异性抗体）。 还提供了包含这种异源多聚体抗体的组合物，用于产生和纯化此类异二聚体抗体的方法及其在诊断和治疗中的应用。
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公开(公告)号：US20240018252A1
公开(公告)日：2024-01-18
申请号：US18456399
申请日：2023-08-25
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K31/454 , A61K39/395 , A61K38/07 , A61P35/00 , A61K31/704
CPC classification number: C07K16/2878 , C07K16/2809 , A61K31/454 , A61K39/3955 , A61K38/07 , A61P35/00 , A61K31/704 , C07K2317/31 , A61K39/00
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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公开(公告)号：US20230059489A1
公开(公告)日：2023-02-23
申请号：US17849467
申请日：2022-06-24
Applicant: PFIZER INC.
Inventor： Danielle Elizabeth DETTLING , Yik Andy YEUNG , Kristian Todd POULSEN , Veena KRISHNAMOORTHY , Cesar Adolfo SOMMER
Abstract: The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML).
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公开(公告)号：US20180346601A1
公开(公告)日：2018-12-06
申请号：US15993874
申请日：2018-05-31
Applicant: PFIZER INC.
Inventor： Danielle Elizabeth DETTLING , Yik Andy YEUNG , Kristian Todd POULSEN , Veena KRISHNAMOORTHY , Cesar Adolfo SOMMER
CPC classification number: C07K16/2863 , A61K2039/505 , A61P35/02 , C07K16/2809 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/71 , C07K2317/73 , C07K2317/92
Abstract: The present invention provides antibodies that specifically bind to FLT3 (Fms-Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML).
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公开(公告)号：US20180298108A1
公开(公告)日：2018-10-18
申请号：US16017974
申请日：2018-06-25
Applicant: PFIZER INC.
Inventor： Tracy Chia-Chien KUO , Javier Fernando CHAPARRO RIGGERS , Wei CHEN , Amy Shaw-Ru CHEN , Edward Derrick PASCUA , Thomas John VAN BLARCOM , Leila Marie BOUSTANY , Weihsien HO , Yik Andy YEUNG , Pavel STROP , Arvind RAJPAL
IPC: C07K16/28 , A61K39/395 , A61K31/704 , A61K31/454 , A61K47/68
Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
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