公开(公告)号：US20180162859A1

公开(公告)日：2018-06-14

申请号：US15892142

申请日：2018-02-08

申请人： PharmAkea, Inc.

发明人： John Howard Hutchinson ,  David Lonergan ,  Martin Rowbottom ,  Andiliy Gokching Lai

IPC分类号： C07D471/14 ,  A61K9/51 ,  A61K31/437 ,  C07D471/12 ,  A61K45/06 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4985 ,  C07D471/22 ,  A61K9/10 ,  C07D498/22 ,  C07D498/14

CPC分类号： C07D471/14 ,  A61K9/10 ,  A61K9/5153 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/12 ,  C07D471/22 ,  C07D498/14 ,  C07D498/22 ,  A61K2300/00

摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.

公开(公告)号：US09926318B2

公开(公告)日：2018-03-27

申请号：US15036370

申请日：2014-11-20

申请人： PharmAkea, Inc.

发明人： John Howard Hutchinson ,  David Lonergan ,  Martin Rowbottom ,  Andiliy Gokching Lai

IPC分类号： A61K31/437 ,  A61K31/4985 ,  C07D471/14 ,  C07D471/22 ,  C07D498/14 ,  C07D471/12 ,  A61K45/06 ,  A61K31/4375 ,  A61K31/444 ,  C07D498/22 ,  A61K9/10 ,  A61K9/51

CPC分类号： C07D471/14 ,  A61K9/10 ,  A61K9/5153 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/12 ,  C07D471/22 ,  C07D498/14 ,  C07D498/22 ,  A61K2300/00

摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.