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公开(公告)号：US09999615B2
公开(公告)日：2018-06-19
申请号：US15261659
申请日：2016-09-09
申请人： PharmAkea, Inc.
IPC分类号： A61K31/4155 , A61K31/4439 , A61K9/00 , A61K9/08 , A61K9/20 , C07D401/04 , C07D401/14 , C07D403/04 , C07D493/10 , A61K45/06 , C07D405/14 , A61K9/06 , A61K9/48
CPC分类号： A61K31/4155 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/4439 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D493/10
摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
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公开(公告)号：US11358936B2
公开(公告)日：2022-06-14
申请号：US16932617
申请日：2020-07-17
申请人： PharmAkea, Inc.
IPC分类号： C07D213/56 , C07D401/14 , C07D401/10 , C07D401/12 , A61K45/06 , C07D213/81 , C07D213/53 , A61P35/00 , C07D213/75 , C07D401/06 , A61P11/00 , C07D213/74 , C07D213/38 , C07D213/55 , C07D213/643 , C07D401/04 , C07D409/12 , C07D417/14
摘要： Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
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公开(公告)号：US10766860B2
公开(公告)日：2020-09-08
申请号：US15555785
申请日：2016-03-03
申请人： PharmAkea, Inc.
IPC分类号： C07D401/12 , C07D213/56 , C07D401/14 , C07D401/10 , A61K45/06 , C07D213/81 , C07D213/53 , A61P35/00 , C07D213/75 , C07D401/06 , A61P11/00 , C07D213/74 , C07D213/38 , C07D213/55 , C07D213/643 , C07D401/04 , C07D409/12 , C07D417/14
摘要： Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
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公开(公告)号：US20180162859A1
公开(公告)日：2018-06-14
申请号：US15892142
申请日：2018-02-08
申请人： PharmAkea, Inc.
IPC分类号： C07D471/14 , A61K9/51 , A61K31/437 , C07D471/12 , A61K45/06 , A61K31/4375 , A61K31/444 , A61K31/4985 , C07D471/22 , A61K9/10 , C07D498/22 , C07D498/14
CPC分类号： C07D471/14 , A61K9/10 , A61K9/5153 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4985 , A61K45/06 , C07D471/12 , C07D471/22 , C07D498/14 , C07D498/22 , A61K2300/00
摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
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公开(公告)号：US09468628B2
公开(公告)日：2016-10-18
申请号：US15060398
申请日：2016-03-03
申请人： PharmAkea, Inc.
IPC分类号： A61K31/4155 , A61K31/4439 , C07D405/14 , C07D403/04 , A61K9/00 , A61K9/20 , A61K9/48 , A61K9/06
CPC分类号： A61K31/4155 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/4439 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D493/10
摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
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公开(公告)号：US11459309B2
公开(公告)日：2022-10-04
申请号：US16983759
申请日：2020-08-03
申请人： PHARMAKEA, INC.
IPC分类号： C07D401/12 , C07D207/12 , A61K31/4439 , C07C309/66
摘要： Described herein are crystalline forms of pharmaceutically acceptable salts of the lysyl oxidase-like 2 (LOXL2) inhibitor (3-(4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yloxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone. Also described are methods of making the LOXL2 inhibitor, pharmaceutical compositions and medicaments comprising the LOXL2 inhibitor, and methods of using the LOXL2 inhibitor in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
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公开(公告)号：US09334261B2
公开(公告)日：2016-05-10
申请号：US14926877
申请日：2015-10-29
申请人： PharmAkea, Inc.
IPC分类号： C07D405/14 , C07D403/04 , C07D401/04 , C07D401/14 , A61K45/06 , A61K31/4155 , A61K31/4439
CPC分类号： A61K31/4155 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/06 , A61K9/08 , A61K9/20 , A61K9/48 , A61K31/4439 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D493/10
摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
摘要翻译： 本文描述的是自分生素抑制剂的化合物，制备这些化合物的方法，药物组合物和包含这些化合物的药物，以及使用这些化合物治疗与自体吸入素活性有关的病症，疾病或病症的方法。
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公开(公告)号：US10774069B2
公开(公告)日：2020-09-15
申请号：US16331095
申请日：2017-09-06
申请人： PHARMAKEA, INC.
IPC分类号： C07D401/12 , C07D207/12 , A61K31/4439 , C07C309/66
摘要： Described herein are crystalline forms of pharmaceutically acceptable salts of the lysyl oxidase-like 2 (LOXL2) inhibitor (3-(4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yloxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone. Also described are methods of making the LOXL2 inhibitor, pharmaceutical compositions and medicaments comprising the LOXL2 inhibitor, and methods of using the LOXL2 inhibitor in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
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公开(公告)号：US09951026B2
公开(公告)日：2018-04-24
申请号：US15022180
申请日：2014-09-16
申请人： PharmAkea, Inc.
IPC分类号： C07D231/56 , C07D401/06 , C07D403/06 , C07D417/06 , C07D471/04 , C07D495/04 , A61K9/00 , A61K9/06 , A61K9/20 , A61K9/48
CPC分类号： C07D231/56 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/06 , A61K9/2054 , A61K9/4866 , C07D401/06 , C07D403/06 , C07D417/06 , C07D471/04 , C07D495/04
摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
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公开(公告)号：US09926318B2
公开(公告)日：2018-03-27
申请号：US15036370
申请日：2014-11-20
申请人： PharmAkea, Inc.
IPC分类号： A61K31/437 , A61K31/4985 , C07D471/14 , C07D471/22 , C07D498/14 , C07D471/12 , A61K45/06 , A61K31/4375 , A61K31/444 , C07D498/22 , A61K9/10 , A61K9/51
CPC分类号： C07D471/14 , A61K9/10 , A61K9/5153 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4985 , A61K45/06 , C07D471/12 , C07D471/22 , C07D498/14 , C07D498/22 , A61K2300/00
摘要： Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
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