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1.发明授权公开(公告)号：US10717734B2
公开(公告)日：2020-07-21
申请号：US16076985
申请日：2017-02-10
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , C07D487/04 , A61K45/06 , C07D209/42 , A61P1/16 , A61P13/12 , A61P11/00 , A61K31/4025 , A61K31/4045 , A61K31/41 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , A61K31/5025 , A61K31/519 , C07D209/20 , C07D209/36
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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2.发明申请公开(公告)号：US20190119269A1
公开(公告)日：2019-04-25
申请号：US16076985
申请日：2017-02-10
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , A61K45/06 , A61K31/437 , C07D209/20 , A61K31/4045 , C07D209/36 , C07D487/04 , A61K31/5025 , A61K31/519 , A61P1/16
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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3.发明授权公开(公告)号：US11098045B2
公开(公告)日：2021-08-24
申请号：US16899116
申请日：2020-06-11
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , C07D487/04 , A61K45/06 , C07D209/42 , A61P1/16 , A61P13/12 , A61P11/00 , A61K31/4025 , A61K31/4045 , A61K31/41 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , A61K31/5025 , A61K31/519 , C07D209/20 , C07D209/36
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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4.发明申请公开(公告)号：US20200317666A1
公开(公告)日：2020-10-08
申请号：US16899116
申请日：2020-06-11
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , C07D487/04 , A61K45/06 , C07D209/42 , A61P1/16 , A61P13/12 , A61P11/00 , A61K31/4025 , A61K31/4045 , A61K31/41 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , A61K31/5025 , A61K31/519 , C07D209/20 , C07D209/36
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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公开(公告)号：US20230257342A1
公开(公告)日：2023-08-17
申请号：US18012540
申请日：2021-06-25
申请人： Pharmaxis Ltd.
发明人： Alan Duncan Robertson , Alison Dorothy Findlay , Alberto Buson , Craig Ivan Turner , Dieter Wolfgang Hamprecht , Jonathan Stuart Foot , Mandar Deodhar , Wolfgang Jarolimek , Serena Becchi , Bernard Walter Balleine , Marcella Canton , Libero Vitiello , Bert Blaauw
IPC分类号： C07C255/54 , A61P9/00 , A61P21/00
CPC分类号： C07C255/54 , A61P9/00 , A61P21/00
摘要： The present invention relates to novel compounds which are capable of inhibiting semicarbazide-sensitive amine oxidase (SSAO/VAP-1) and monoamine oxidase B (MAO-B). These compounds are useful for treatment of a variety of neuromuscular diseases, such as muscular dystrophies, and neuroinflammatory diseases, including both peripheral and central disorders in human subjects, as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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6.发明授权公开(公告)号：US10717733B2
公开(公告)日：2020-07-21
申请号：US16076979
申请日：2017-02-10
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D471/04 , C07D487/04 , A61K45/06 , C07D209/42 , A61P1/16 , A61P13/12 , A61P11/00 , A61K31/4025 , A61K31/4045 , A61K31/41 , A61K31/4245 , A61K31/437 , A61K31/4439 , A61K31/506 , C07D209/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D413/10 , A61K31/5025 , A61K31/519 , C07D209/20 , C07D209/36
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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7.发明申请公开(公告)号：US20190040007A1
公开(公告)日：2019-02-07
申请号：US16076979
申请日：2017-02-10
申请人： PHARMAXIS LTD.
发明人： Alison Dorothy Findlay , Craig Ivan Turner , Mandar Deodhar , Jonathan Stuart Foot , Wolfgang Jarolimek , Wenbin Zhou , Alan Duncan Robertson
IPC分类号： C07D209/14 , C07D471/04 , A61K45/06 , A61K31/4045 , A61K31/4025 , A61K31/4439 , C07D401/04 , A61K31/437 , C07D403/04 , A61K31/506 , C07D403/10 , A61K31/41 , C07D413/10 , A61K31/4245 , A61P1/16 , A61P11/00 , A61P13/12
摘要： The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as in pets and livestock. In addition, the present invention relates to pharmaceutical compositions containing these compounds, as well as various uses thereof.
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