公开(公告)号：US07835800B1

公开(公告)日：2010-11-16

申请号：US12334455

申请日：2008-12-13

申请人： Philip A Segel ,  Tracey L Kruger ,  Leonid M Litvak

发明人： Philip A Segel ,  Tracey L Kruger ,  Leonid M Litvak

IPC分类号： A61N1/36 ,  A61F11/04 ,  A61F11/00

CPC分类号： A61N1/36036

摘要： An adaptive place-pitch ranking procedure for use with a cochlear implant or other neural stimulation system provides a systematic method for quantifying the magnitude and direction of errors along the place-pitch continuum. The method may be conducted and completed in a relatively short period of time. In use, the implant user or listener is asked to rank the percepts obtained after a sequential presentation of monopolar stimulation pulses are applied to a selected spatially-defined electrode pair. The spatially-defined electrode pair may be a physical electrode pair or a virtual electrode pair. A virtual electrode pair includes at least one virtual electrode contact. Should the patient's judgment of pitch order be correct for all applied interrogations, then no further testing involving the tested electrode pair (two electrode contacts) is undertaken. However, should there be errors in the place-pitch ranking, which errors evidence perceptual place-confusions, then a search is undertaken for the spread of the perceptual confusion. This search for the spread of confusion continues until no errors are made in all directions. Identified channels wherein pitch confusion exists may be de-selected (not used) during normal operation of the cochlear implant or other neural stimulation system.

摘要翻译： 用于耳蜗植入物或其他神经刺激系统的自适应放置间距分级程序提供了一种用于量化沿着位置 - 俯仰连续体的误差的大小和方向的系统方法。 该方法可以在相当短的时间内进行和完成。 在使用中，要求植入用户或收听者将单极刺激脉冲的顺序呈现施加到所选择的空间限定电极对之后获得的感知进行排名。 空间限定的电极对可以是物理电极对或虚拟电极对。 虚拟电极对包括至少一个虚拟电极触点。 如果患者对所有应用询问的音调顺序的判断是正确的，则不进行涉及被测电极对（两个电极接触）的进一步测试。 然而，如果地方间距排序有错误，哪些错误证据感知地点混淆，那么就会对感知混乱的扩散进行搜索。 这种寻求混乱的传播继续下去，直到在所有方向没有错误。 在耳蜗植入物或其他神经刺激系统的正常操作期间，存在音高混乱存在的识别的通道可被取消选择（未使用）。

公开(公告)号：US07835799B1

公开(公告)日：2010-11-16

申请号：US12334453

申请日：2008-12-13

申请人： Philip A Segel ,  Tracey L Kruger ,  Leonid M Litvak

发明人： Philip A Segel ,  Tracey L Kruger ,  Leonid M Litvak

IPC分类号： A61N1/36 ,  A61F11/04 ,  A61F11/00

CPC分类号： A61N1/36036

摘要： An adaptive place-pitch ranking procedure for use with a cochlear implant or other neural stimulation system provides a systematic method for quantifying the magnitude and direction of errors along the place-pitch continuum. The method may be conducted and completed in a relatively short period of time. In use, the implant user or listener is asked to rank the percepts obtained after a sequential presentation of monopolar stimulation pulses are applied to a selected spatially-defined electrode pair. The spatially-defined electrode pair may be a physical electrode pair or a virtual electrode pair. A virtual electrode pair includes at least one virtual electrode contact. Should the patient's judgment of pitch order be correct for all applied interrogations, then no further testing involving the tested electrode pair (two electrode contacts) is undertaken. However, should there be errors in the place-pitch ranking, which errors evidence perceptual place-confusions, then a search is undertaken for the spread of the perceptual confusion. This search for the spread of confusion continues until no errors are made in all directions. Identified channels wherein pitch confusion exists may be de-selected (not used) during normal operation of the cochlear implant or other neural stimulation system.

摘要翻译： 用于耳蜗植入物或其他神经刺激系统的自适应放置间距分级程序提供了一种用于量化沿着位置 - 俯仰连续体的误差的大小和方向的系统方法。 该方法可以在相当短的时间内进行和完成。 在使用中，要求植入用户或收听者将单极刺激脉冲的顺序呈现施加到所选择的空间限定电极对之后获得的感知进行排名。 空间限定的电极对可以是物理电极对或虚拟电极对。 虚拟电极对包括至少一个虚拟电极触点。 如果患者对所有应用询问的音调顺序的判断是正确的，则不进行涉及被测电极对（两个电极接触）的进一步测试。 然而，如果地方间距排序有错误，哪些错误证据感知地点混淆，那么就会对感知混乱的扩散进行搜索。 这种寻求混乱的传播继续下去，直到在所有方向没有错误。 在耳蜗植入物或其他神经刺激系统的正常操作期间，存在音高混乱存在的识别的通道可被取消选择（未使用）。

公开(公告)号：US07571005B1

公开(公告)日：2009-08-04

申请号：US11469820

申请日：2006-09-01

申请人： Philip A Segel ,  Tracey L. Kruger ,  Leonid M Litvak

发明人： Philip A Segel ,  Tracey L. Kruger ,  Leonid M Litvak

IPC分类号： A61N1/36 ,  A61F11/04 ,  A61F11/00

CPC分类号： A61N1/36036

摘要： An adaptive place-pitch ranking procedure for use with a cochlear implant or other neural stimulation system provides a systematic method for quantifying the magnitude and direction of errors along the place-pitch continuum. The method may be conducted and completed in a relatively short period of time. In use, the implant user or listener is asked to rank the percepts obtained after a sequential presentation of monopolar stimulation pulses are applied to a selected spatially-defined electrode pair. The spatially-defined electrode pair may be a physical electrode pair or a virtual electrode pair. A virtual electrode pair includes at least one virtual electrode contact. Should the patient's judgment of pitch order be correct for all applied interrogations, then no further testing involving the tested electrode pair (two electrode contacts) is undertaken. However, should there be errors in the place-pitch ranking, which errors evidence perceptual place-confusions, then a search is undertaken for the spread of the perceptual confusion. This search for the spread of confusion continues until no errors are made in all directions. Identified channels wherein pitch confusion exists may be de-selected (not used) during normal operation of the cochlear implant or other neural stimulation system.

摘要翻译： 用于耳蜗植入物或其他神经刺激系统的自适应放置间距分级程序提供了一种用于量化沿着位置 - 俯仰连续体的误差的大小和方向的系统方法。 该方法可以在相当短的时间内进行和完成。 在使用中，要求植入用户或收听者将单极刺激脉冲的顺序呈现施加到所选择的空间限定电极对之后获得的感知进行排名。 空间限定的电极对可以是物理电极对或虚拟电极对。 虚拟电极对包括至少一个虚拟电极触点。 如果患者对所有应用询问的音调顺序的判断是正确的，则不进行涉及被测电极对（两个电极接触）的进一步测试。 然而，如果地方间距排序有错误，哪些错误证据感知地点混淆，那么就会对感知混乱的扩散进行搜索。 这种寻求混乱的传播继续下去，直到在所有方向没有错误。 在耳蜗植入物或其他神经刺激系统的正常操作期间，存在音高混乱存在的识别的通道可被取消选择（未使用）。

公开(公告)号：US07805198B2

公开(公告)日：2010-09-28

申请号：US11830846

申请日：2007-07-31

申请人： Edward H Overstreet ,  Leonid M Litvak ,  William Vanbrooks Harrison

发明人： Edward H Overstreet ,  Leonid M Litvak ,  William Vanbrooks Harrison

IPC分类号： A61N1/00

CPC分类号： A61N1/36036

摘要： Errors in pitch (frequency) allocation within a cochlear implant are corrected in order to provide a significant and profound improvement in the quality of sound perceived by the cochlear implant user. In one embodiment, the user is stimulated with a reference signal, e.g., the tone “A” (440 Hz) and then the user is stimulated with a probe signal, separated from the reference signal by an octave, e.g., high “A” (880 Hz). The user adjusts the location where the probe signal is applied, using current steering, until the pitch of the probe signal, as perceived by the user, matches the pitch of the reference signal, as perceived by the user. In this manner, the user maps frequencies to stimulation locations in order to tune his or her implant system to his or her unique cochlea.

摘要翻译： 修正耳蜗植入物内的间距（频率）分配的误差，以便对由人工耳蜗植入物使用者感知到的声音的质量提供显着和深刻的改善。 在一个实施例中，用参考信号（例如，音调“A”（440Hz））刺激用户，然后用探测信号刺激用户，该探测信号与参考信号分开八度，例如高“A” （880Hz）。 用户使用当前转向来调整应用探测信号的位置，直到由用户感知到的探测信号的音高与用户感知到的参考信号的音调相匹配。 以这种方式，用户将频率映射到刺激位置，以便将他或她的植入系统调整到他或她的独特的耳蜗。

公开(公告)号：US07496405B1

公开(公告)日：2009-02-24

申请号：US11080196

申请日：2005-03-14

申请人： Leonid M Litvak ,  Lee F Hartley ,  Tracey Kruger

发明人： Leonid M Litvak ,  Lee F Hartley ,  Tracey Kruger

IPC分类号： A61N1/08

CPC分类号： A61N1/36036

摘要： Sound processing strategies for use with cochlear implant systems utilizing simultaneous stimulation of electrodes are provided. The strategies include computing a frequency spectrum of a signal representative of sound, arranging the spectrum into channels and assigning a subset of electrodes to each channel. Each subset is stimulated so as to stimulate a virtual electrode positioned at a location on the cochlea that corresponds to the frequency at which a spectral peak is located within an assigned channel. The strategies also derive a carrier for a channel having a frequency that may relate to the stimulation frequency so that temporal information is presented. In order to fit these strategies, a group of electrodes is selected and the portion of the current that would otherwise be applied to electrode(s) having a partner electrode in the group is applied to the partner electrode.

摘要翻译： 提供了用于同时刺激电极的人工耳蜗植入系统的声音处理策略。 该策略包括计算表示声音的信号的频谱，将频谱排列成通道并将电极的子集分配给每个通道。 刺激每个子集，以便刺激位于耳蜗上位于分配频道内的频谱峰位置处的频率的虚拟电极。 该策略还导出具有可以与刺激频率相关的频率的信道的载波，从而呈现时间信息。 为了适应这些策略，选择一组电极，否则将施加到组中具有配对电极的电极的电流部分被施加到配对电极。

公开(公告)号：US07171261B1

公开(公告)日：2007-01-30

申请号：US10741410

申请日：2003-12-19

申请人： Leonid M Litvak ,  Edward H Overstreet

发明人： Leonid M Litvak ,  Edward H Overstreet

IPC分类号： A61B5/04

CPC分类号： A61B5/04001 ,  A61B5/4041

摘要： An improved forward-masking method of recording and processing neural responses (“NR”) is provided, wherein the method does not assume a linear system response and does not assume a linear response at the interface between electrodes and tissue. The method of the present invention cancels out non-linearities and/or system hysteresis. Other artifacts such as system cross-talk between stimulation and recording circuits are also canceled out.

摘要翻译： 提供了一种改进的记录和处理神经反应的前向掩蔽方法（“NR”），其中该方法不呈现线性系统响应，并且在电极和组织之间的界面处不呈现线性响应。 本发明的方法消除非线性和/或系统滞后。 诸如刺激和记录电路之间的系统串扰的其他伪影也被抵消。

公开(公告)号：US07283877B1

公开(公告)日：2007-10-16

申请号：US10741409

申请日：2003-12-19

申请人： Leonid M Litvak ,  Edward H Overstreet

发明人： Leonid M Litvak ,  Edward H Overstreet

IPC分类号： A61N1/00

CPC分类号： A61B5/04001 ,  A61N1/36071

摘要： A new method of recording and processing neural responses (“NR”) is provided, wherein the method does not assume a linear system response and does not assume a linear response at the interface between electrodes and tissue. The method of the present invention cancels out non-linearities and/or system hysteresis. Other artifacts such as system cross-talk between stimulation and recording circuits are also canceled out. The method provided uses at least two stimulating electrodes simultaneously in one recording step.

摘要翻译： 提供了一种记录和处理神经反应（“NR”）的新方法，其中该方法不呈现线性系统响应，并且在电极和组织之间的界面处不呈现线性响应。 本发明的方法消除非线性和/或系统滞后。 诸如刺激和记录电路之间的系统串扰的其他伪影也被抵消。 所提供的方法在一个记录步骤中同时使用至少两个刺激电极。

公开(公告)号：US08364274B1

公开(公告)日：2013-01-29

申请号：US11962508

申请日：2007-12-21

申请人： Leonid M Litvak

发明人： Leonid M Litvak

IPC分类号： A61N1/05

CPC分类号： A61B5/04845 ,  A61B5/125 ,  A61N1/36032 ,  A61N1/36036 ,  A61N1/37247 ,  A61N1/37264

摘要： Systems for detecting one or more central auditory potentials include an implantable cochlear stimulator configured to be implanted within a patient and to generate a stimulation current in accordance with one or more stimulation parameters, a signal processing unit configured to be located external to the patient and to be communicatively coupled to the implantable cochlear stimulator, and one or more electrodes configured to be removably coupled to the signal processing unit. The electrodes are configured to detect the one or more central auditory potentials and the signal processing unit is configured to process the detected central auditory potentials.

摘要翻译： 用于检测一个或多个中心听觉电位的系统包括被配置为植入患者体内并根据一个或多个刺激参数产生刺激电流的植入式耳蜗刺激器，被配置为位于病人外部的信号处理单元， 通信地耦合到可植入耳蜗刺激器，以及被配置为可移除地耦合到信号处理单元的一个或多个电极。 电极被配置为检测一个或多个中心听觉电位，并且信号处理单元被配置为处理检测到的中心听觉电位。

公开(公告)号：US07747329B2

公开(公告)日：2010-06-29

申请号：US11841501

申请日：2007-08-20

申请人： Leonid M Litvak ,  Lakshmi N. Mishra

发明人： Leonid M Litvak ,  Lakshmi N. Mishra

IPC分类号： A61N1/05 ,  A61B5/04

CPC分类号： A61N1/36036 ,  H04R2225/67

摘要： Systems for fitting an implantable cochlear stimulator to a patient include an interface unit configured to display a graphical representation of an implant fitting line as part of a graphical user interface. The implant fitting line has a slope and a horizontal position and represents a mapping relationship between a plurality of audio frequencies and a plurality of stimulation sites within a cochlea of the patient. The interface unit is further configured to facilitate adjustment of the slope and/or horizontal position of the fitting line.

摘要翻译： 用于将可植入人工耳蜗刺激器装配到患者的系统包括被配置为作为图形用户界面的一部分显示植入物嵌合线的图形表示的界面单元。 植入物嵌合线具有斜率和水平位置，并且表示多个音频频率与患者的耳蜗内的多个刺激部位之间的映射关系。 接口单元还被配置为便于调整装配线的斜率和/或水平位置。

公开(公告)号：US07616999B2

公开(公告)日：2009-11-10

申请号：US11697605

申请日：2007-04-06

申请人： Edward H Overstreet ,  Leonid M Litvak ,  Michael A Faltys

发明人： Edward H Overstreet ,  Leonid M Litvak ,  Michael A Faltys

IPC分类号： A61N1/18

CPC分类号： A61N1/37241 ,  A61N1/0541 ,  A61N1/36036 ,  A61N1/37247

摘要： A multichannel cochlear implant system spatially spreads the excitation pattern in the target neural tissue by either: (1) rapid sequential stimulation of a small group of electrodes, or (2) simultaneously stimulating a small group of electrodes. Such multi-electrode stimulation stimulates a greater number of neurons in a synchronous manner, thereby increasing the amplitude of the extra-cellular voltage fluctuation and facilitating its recording. The electrical stimuli are applied simultaneously (or sequentially at a rapid rate) on selected small groups of electrodes while monitoring the evoked compound action potential (ECAP) on a nearby electrode. The presence of an observable ECAP not only validates operation of the implant device at a time when the patient may be unconscious or otherwise unable to provide subjective feedback, but also provides a way for the magnitude of the observed ECAP to be recorded as a function of the amplitude of the applied stimulus. From this data, a safe, efficacious and comfortable threshold level can be obtained which may be used thereafter as the initial setting of the stimulation parameters of the neurostimulation device, or to guide the setting of the stimulation parameters of the neurostimulation device.

摘要翻译： 多通道人工耳蜗植入系统通过以下方式之一空间扩展靶神经组织中的激发图案：（1）对一小组电极的快速连续刺激，或（2）同时刺激一小组电极。 这种多电极刺激以同步方式刺激更多数量的神经元，从而增加细胞外电压波动的幅度并促进其记录。 电刺激同时（或以快速顺序）施加在选定的小组电极上，同时监测附近电极上的诱发化合物动作电位（ECAP）。 可观察到的ECAP的存在不仅在患者无意识或不能提供主观反馈的时候验证植入装置的操作，而且还提供了将所观察到的ECAP的大小记录为作为 施加的刺激的幅度。 从该数据可以获得安全，有效和舒适的阈值水平，其可以随后用作神经刺激装置的刺激参数的初始设置，或者指导神经刺激装置的刺激参数的设置。