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公开(公告)号：US5209927A
公开(公告)日：1993-05-11
申请号：US716426
申请日：1991-06-17
CPC分类号： A61K31/78 , A61K9/0048 , Y10S514/915
摘要： Disclosed is a liquid ophthalmic composition of unique rheological and lubricating properties comprising, inter alia, a polyanionic polymer for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising topically administering the composition when indicated for relief of dry eye syndrome, foreign body sensation, burning, hyperemia, corneal staining, and the like.
摘要翻译： 公开了独特的流变学和润滑性质的液体眼用组合物，其特别包括用作持久人造泪液的聚阴离子聚合物。 还公开了一种治疗方法，包括当指定用于缓解干眼综合征，异物感觉，烧灼，充血，角膜染色等时局部施用组合物。
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2.发明授权
公开(公告)号：US4966773A
公开(公告)日：1990-10-30
申请号：US339915
申请日：1989-04-17
CPC分类号： A61K31/20 , A61K9/0048 , Y10S514/912 , Y10S514/915
摘要： Topical ophthalmic compositions containing microfine particles of one or more retinoids are described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.
摘要翻译： 描述了含有一种或多种类视黄醇的微细颗粒的局部眼用组合物。 该组合物可用于治疗干眼综合征和相关的眼表疾病和眼部润滑剂。 还描述了治疗干眼综合征和相关眼表疾病的方法以及使用这些组合物提供局部眼部润滑的方法。
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公开(公告)号：US5075104A
公开(公告)日：1991-12-24
申请号：US597983
申请日：1990-10-15
IPC分类号： A61K9/00 , A61K31/765 , A61K31/78
CPC分类号： A61K31/78 , A61K31/765 , A61K9/0048 , Y10S514/912 , Y10S514/915
摘要： Disclosed is an ophthalmic gel composition of unique rheological and lubricating properties comprising, inter alia, a carboxy vinyl polymer (carbomer) for use as a long lasting artificial tear. Also disclosed is a method of treatment comprising totally administering the composition when indicated for relief of dry eye syndrom, foreign body sensation, burning, hyperemia, corneal straining, and the like.
摘要翻译： 公开了独特的流变学和润滑性质的眼用凝胶组合物，其特别包括用作持久人造泪液的羧乙烯基聚合物（卡波姆）。 还公开了一种治疗方法，包括当指定用于缓解干眼综合征，异物感觉，烧灼，充血，角膜应变等时完全施用该组合物。
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公开(公告)号：US4826871A
公开(公告)日：1989-05-02
申请号：US935477
申请日：1986-11-26
CPC分类号： A61K31/045 , A61K31/07 , A61K31/11 , A61K31/34 , A61K31/38 , A61K9/0048 , Y10S514/915
摘要： Topical ophthalmic compositions containing one or more retinoids selected from the group consisting of near and remote analogues and derivatives of retinoic acid are described. Six classes of ophthalmic vehicles suitable as carriers for the retinoids are also described. The compositions are useful in the treatment of dry eye syndrome and related ophthalmic surface disorders and as ocular lubricants. A method of treating dry eye syndrome and related ophthalmic surface disorders and a method of providing topical ocular lubrication using these compositions are also described.
摘要翻译： 描述了含有一种或多种类视黄醇的局部眼用组合物，其选自近视和远程类似物和视黄酸衍生物。 还描述了适合作为类视色素的载体的六类眼科车辆。 该组合物可用于治疗干眼综合征和相关的眼表疾病和眼部润滑剂。 还描述了治疗干眼综合征和相关眼表疾病的方法以及使用这些组合物提供局部眼部润滑的方法。
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公开(公告)号：US5403598A
公开(公告)日：1995-04-04
申请号：US177892
申请日：1994-01-06
CPC分类号： A61K33/14 , A61K33/30 , A61K9/0048 , Y10S514/912
摘要： Non-preserved physiological tear compositions comprise the ionic components of normal human tear film in substantially the same amounts and proportions. Novel methods of preparation of these compositions and novel packaging allow the maintenance of the bicarbonate concentration in these compositions.
摘要翻译： 非保存的生理性眼泪组合物以基本上相同的量和比例包含正常人类泪液膜的离子组分。 制备这些组合物和新型包装的新方法可以维持这些组合物中的碳酸氢盐浓度。
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