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    Polyacid/polyalkylene oxide gels and methods for their delivery
    2.
    发明授权
    Polyacid/polyalkylene oxide gels and methods for their delivery 有权
    多酸/聚环氧烷凝胶及其输送方法

    公开(公告)号：US07265098B2

    公开(公告)日：2007-09-04

    申请号：US10371124

    申请日：2003-02-20

    申请人： Mark E. Miller ,  Stephanie M. Cortese ,  Herbert E. Schwartz ,  William G. Oppelt

    发明人： Mark E. Miller ,  Stephanie M. Cortese ,  Herbert E. Schwartz ,  William G. Oppelt

    IPC分类号： A61K31/175 ,  C07H1/00

    CPC分类号： A61L31/041 ,  A61K9/122 ,  A61K9/7007 ,  A61K31/715 ,  A61K31/717 ,  A61K31/721 ,  A61K31/722 ,  A61K31/727 ,  A61K31/728 ,  A61K31/74 ,  A61K38/00 ,  A61K47/32 ,  A61K47/38 ,  A61L15/225 ,  A61L15/44 ,  A61L31/16 ,  A61L2300/00 ,  A61L2300/418 ,  A61L2400/04 ,  C08L1/286 ,  C08L67/00 ,  C08L71/02 ,  C08L77/00 ,  C08L85/00 ,  C08L85/02 ,  Y10S514/912 ,  Y10S514/915 ,  C08L1/28 ,  C08L2666/22 ,  C08L2666/04 ,  C08L2666/26 ,  C08L2666/18 ,  C08L2666/20 ,  C08L2666/02

    摘要： The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylene oxides, multivalent cations and/or polycations. The polymers are associated with each other, and are then used as fluids, gels or foams. By providing a product bag, the compositions can be delivered as gels or as sprays. By dissolving propellant gases in the compositions, the materials can be delivered as foams, which have decreased density, and therefore can adhere to surfaces that previously have been difficult to coat with antiadhesion gels. Delivery systems can also provide mechanisms for expelling more product, and for directing the flow of materials leaving the delivery system. Bioresorbable, bioadhesive, anti-adhesion, and/or hemostatic compositions are useful in surgery to prevent the formation and reformation of post-surgical adhesions. The biological and physical properties of such compositions can be varied as needed by carefully adjusting the pH and/or cation content of the polymer casting solutions, polyacid composition, the polyalkylene oxide composition, or by selecting the solids content of the composition. Antiadhesion compositions may also be used to lubricate tissues and/or medical instruments, and/or deliver drugs to the surgical site and release them locally.

    摘要翻译： 本发明涉及用于递送生物粘附剂，生物可吸收的，抗粘连组合物的改进方法。 抗粘附组合物可以由含羧基的多糖，聚醚，多元酸，聚环氧烷，多价阳离子和/或聚阳离子的大分子间复合物制成。 聚合物彼此相关，然后用作流体，凝胶或泡沫。 通过提供产品袋，组合物可以作为凝胶或喷雾剂递送。 通过将推进剂气体溶解在组合物中，材料可以作为泡沫输送，其具有降低的密度，因此可以粘附到以前难以用抗粘着性凝胶涂覆的表面上。 输送系统还可以提供排出更多产品的机制，并指导离开输送系统的物料流。 生物可再吸收，生物粘附，抗粘连和/或止血组合物可用于手术以防止手术后粘连的形成和改造。 通过仔细调整聚合物浇铸溶液，多酸组合物，聚环氧烷组合物的pH和/或阳离子含量，或通过选择组合物的固体含量，可以根据需要改变这些组合物的生物和物理性质。 抗粘合组合物也可用于润滑组织和/或医疗器械，和/或将药物递送至外科手术部位并在局部释放。

    Ophthalmic fluid
    3.
    发明授权
    Ophthalmic fluid 失效
    眼液

    公开(公告)号：US07115667B2

    公开(公告)日：2006-10-03

    申请号：US10781179

    申请日：2004-02-18

    申请人： Anthony William Sly

    发明人： Anthony William Sly

    IPC分类号： A61K47/30

    CPC分类号： A61K47/14 ,  A61K9/0048 ,  A61K31/231 ,  A61K31/232 ,  A61K47/44 ,  Y10S514/912 ,  Y10S514/915

    摘要： An ophthalmic fluid containing at least one triglyceride, diglyceride, or monoglyceride which is chemically similar or compatible with compounds found naturally in the lipid layer of the tear film of an ocular substrate. Preferably the glycerides are derived from a fatty acid containing at least one unsaturated bond in a cis-configuration in the fatty acid residue. The ophthalmic fluid is arranged in use to provide a protective film across a tear film of an ocular substrate. Furthermore, the ophthalmic fluid is also arranged in use to provide a protective film intermediate a lipid layer of the tear film of the ocular substrate and a contact lens.

    摘要翻译： 含有至少一种甘油三酸酯，甘油二酸酯或单酸甘油酯的眼药液，其化学相似或与眼底物的泪膜的脂质层天然存在的化合物相容。 优选地，甘油酯衍生自在脂肪酸残基中具有顺式构型的至少一个不饱和键的脂肪酸。 在使用中布置眼科流体以在眼底物的泪膜上提供保护膜。 此外，眼用流体也被布置为用于提供在眼底物的泪膜的脂质层和隐形眼镜之间的保护膜。

    Method of treating dry eye disease with purinergic receptor agonists
    7.
    发明申请
    Method of treating dry eye disease with purinergic receptor agonists 有权
    用嘌呤能受体激动剂治疗干眼病的方法

    公开(公告)号：US20020103157A1

    公开(公告)日：2002-08-01

    申请号：US10041826

    申请日：2002-01-03

    发明人： Benjamin R. Yerxa ,  Karla M. Jacobus ,  William Pendergast ,  Janet L. Rideout

    IPC分类号： A61K031/7105

    CPC分类号： C07H19/10 ,  A61K9/0048 ,  A61K31/7084 ,  A61K45/06 ,  C07H19/20 ,  C07H21/00 ,  Y10S514/912 ,  Y10S514/915

    摘要： A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5null-triphosphate (UTP), dinucleotides, cytidine 5null-triphosphate (CTP), adenosine 5null-triphosphate (ATP), or their therapeutically useful analogs and derivatives, in an amount effective to stimulate tear fluid secretion and enhance drainage of the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.

    摘要翻译： 公开了用于刺激需要这种治疗的受试者的泪液分泌的方法和制剂。 该方法包括向受试者的眼表面施用嘌呤能受体激动剂如尿苷5'-三磷酸（UTP），二核苷酸，胞苷5'-三磷酸（CTP），腺苷5'-三磷酸（ATP）或其治疗上有用的 类似物和衍生物，其量有效地刺激泪液分泌并增强泪液系统的引流。 还公开了药物制剂及其制备方法。 施用该方法的方法将包括：通过液体，凝胶，霜剂或作为隐形眼镜或选择性释放膜的一部分局部给药; 或通过鼻滴或喷雾进行全身给药，通过喷雾器或其它装置吸入，口服形式（液体或丸剂），可注射的，术中滴注或栓剂形式。

    Muco-adhesive polymers
    10.
    发明授权
    Muco-adhesive polymers 失效
    粘胶聚合物

    公开(公告)号：US5645827A

    公开(公告)日：1997-07-08

    申请号：US375498

    申请日：1995-01-19

    申请人： Lawrence Marlin ,  Ronald Kenichi Yamamoto

    发明人： Lawrence Marlin ,  Ronald Kenichi Yamamoto

    IPC分类号： A61K9/00 ,  A61K31/74 ,  A61K47/36

    CPC分类号： A61K9/0048 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914 ,  Y10S514/915

    摘要： Compositions comprising cationic polysaccharide polymers and anionic therapeutic agents which can have enhanced substantivity to mucosal surfaces are disclosed. These compositions are well suited, for example, for the delivery of anionic ophthalmic pharmaceuticals because they can provide clear solution in addition to substantivity.

    摘要翻译： 公开了包含阳离子多糖聚合物和阴离子治疗剂的组合物，其可以具有增强的对粘膜表面的亲和性。 这些组合物非常适合于例如用于递送阴离子眼用药物，因为它们除了具有亲和性之外还能够提供清晰的溶液。