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公开(公告)号:US20120087925A1
公开(公告)日:2012-04-12
申请号:US13296778
申请日:2011-11-15
IPC分类号: A61K39/395 , A61P19/02
CPC分类号: C07K16/2842 , A61K2039/505 , C07K16/2821 , C07K16/2839 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要: A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable of binding an epitope of VLA-1.
摘要翻译: 公开了治疗炎症性疾病的方法,特别是治疗关节炎。 该方法包括施用能够结合VLA-1表位的功能阻断抗体。
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公开(公告)号:US20070048321A1
公开(公告)日:2007-03-01
申请号:US11586441
申请日:2006-10-24
申请人: Philip Gotwals , Victor Kotelianski
发明人: Philip Gotwals , Victor Kotelianski
IPC分类号: A61K39/395
CPC分类号: C07K16/2842 , A61K2039/505 , C07K2317/34
摘要: Disclosed is a method of treating fibrosis in a human or animal subject. The method comprises administering to the subject an effective amount of an antibody to an integrin or fragment thereof.
摘要翻译: 公开了一种治疗人或动物受试者的纤维化的方法。 该方法包括向受试者施用有效量的抗体至整联蛋白或其片段。
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公开(公告)号:US20050226877A1
公开(公告)日:2005-10-13
申请号:US11108581
申请日:2005-04-18
IPC分类号: A61K39/395 , A61K20060101 , A61P20060101 , A61P1/02 , A61P1/04 , A61P1/06 , A61P3/10 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07K20060101 , C07K16/28
CPC分类号: C07K16/2842 , A61K2039/505 , C07K16/2821 , C07K16/2839 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要: A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable of binding an epitope of VLA-1.
摘要翻译: 公开了治疗炎症性疾病的方法,特别是治疗关节炎。 该方法包括施用能够结合VLA-1表位的功能阻断抗体。
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公开(公告)号:US20050281818A1
公开(公告)日:2005-12-22
申请号:US11192449
申请日:2005-07-28
申请人: Philip Gotwals , Victor Kotelianski
发明人: Philip Gotwals , Victor Kotelianski
IPC分类号: A61K39/395 , A61P1/16 , A61P9/00 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P37/00 , C07K16/28
CPC分类号: C07K16/2839 , A61K2039/505 , C07K16/2842
摘要: Disclosed is a method of treating fibrosis in a human or animal subject. The method comprises administering to the subject an effective amount of an antibody to an integrin or fragment thereof.
摘要翻译: 公开了一种治疗人或动物受试者的纤维化的方法。 该方法包括向受试者施用有效量的抗体至整联蛋白或其片段。
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公开(公告)号:US20090324598A1
公开(公告)日:2009-12-31
申请号:US12268459
申请日:2008-11-11
IPC分类号: A61K39/395
CPC分类号: C07K16/2842 , A61K2039/505 , C07K16/2821 , C07K16/2839 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要: A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable of binding an epitope of VLA-1.
摘要翻译: 公开了治疗炎症性疾病的方法,特别是治疗关节炎。 该方法包括施用能够结合VLA-1表位的功能阻断抗体。
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公开(公告)号:US08084031B2
公开(公告)日:2011-12-27
申请号:US12268459
申请日:2008-11-11
IPC分类号: A61K39/395 , C07K16/28
CPC分类号: C07K16/2842 , A61K2039/505 , C07K16/2821 , C07K16/2839 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要: A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable of binding an epitope of VLA-1.
摘要翻译: 公开了治疗炎症性疾病的方法,特别是治疗关节炎。 该方法包括施用能够结合VLA-1表位的功能阻断抗体。
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公开(公告)号:US06955810B2
公开(公告)日:2005-10-18
申请号:US09996738
申请日:2001-11-30
IPC分类号: A61K39/395 , A61K20060101 , A61P20060101 , A61P1/02 , A61P1/04 , A61P1/06 , A61P3/10 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07K20060101 , C07K16/28
CPC分类号: C07K16/2842 , A61K2039/505 , C07K16/2821 , C07K16/2839 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要: A method for the treatment of inflammatory disorders is disclosed, particularly the treatment of arthritis. The method comprises the administration of a function blocking antibody which is capable of binding an epitope of VLA-1.
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公开(公告)号:US20130158097A1
公开(公告)日:2013-06-20
申请号:US13701551
申请日:2011-06-02
IPC分类号: C07H21/02
CPC分类号: C07H21/02 , C07K14/4705 , C07K14/495 , C07K14/78 , C12N15/113 , C12N2310/14
摘要: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-β, and SMAD2/3 genes, and methods of using such dsRNA compositions to inhibit expression of COL1A1, TGF-β, and SMAD2/3.
摘要翻译: 本发明涉及靶向COL1A1,TGF-β和SMAD2 / 3基因的双链核糖核酸(dsRNA)组合物,以及使用这些dsRNA组合物抑制COL1A1,TGF-β和SMAD2 / 3表达的方法。
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公开(公告)号:US20070009518A1
公开(公告)日:2007-01-11
申请号:US11436055
申请日:2006-05-18
IPC分类号: A61K39/395 , A61K39/00
CPC分类号: C07K16/2887 , A61K38/10 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/73
摘要: The present invention is directed to methods for treating fibrosis conditions, such as liver, kidney and lung fibrosis, as well as fibrosis conditions of other tissues of the body. The methods of the invention comprise administering to a patient in need of such treatment a therapeutically effective amount of a B-cell antagonist. Exemplary B-cell antagonists that can be used in the practice of the methods of the invention include antibodies against B-cell surface antigens (e.g., antibodies against CD20), and BAFF antagonists.
摘要翻译: 本发明涉及用于治疗纤维化病症如肝,肾和肺纤维化的方法,以及身体其他组织的纤维化病症。 本发明的方法包括向需要这种治疗的患者施用治疗有效量的B细胞拮抗剂。 可用于实施本发明方法的示例性B细胞拮抗剂包括抗B细胞表面抗原的抗体(例如针对CD20的抗体)和BAFF拮抗剂。
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公开(公告)号:US20070134236A1
公开(公告)日:2007-06-14
申请号:US10536067
申请日:2003-11-25
申请人: Antonin De Fougerolles , Victor Kotelianski , Ellen Garber , Carl Reid , Jose Saldanha , Herman Vlijmen
发明人: Antonin De Fougerolles , Victor Kotelianski , Ellen Garber , Carl Reid , Jose Saldanha , Herman Vlijmen
IPC分类号: A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/18
CPC分类号: C07K16/24 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要: The invention provides humanized antibodies that bind to a plurality of b-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. The invention also provides therapeutic reagents and methods of treating disorders associated with detrimental MCP activity.
摘要翻译: 本发明提供结合多种b趋化因子,特别是单核细胞趋化蛋白MCP-1,MCP-2和MCP-3的人源化抗体。 本发明还提供治疗药物和治疗与有害MCP活性相关的疾病的方法。
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