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公开(公告)号：US20130158106A1
公开(公告)日：2013-06-20
申请号：US13701630
申请日：2011-06-02
IPC分类号： C07D311/72
CPC分类号： C07D311/72 , C07D311/58
摘要： Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the α-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.
摘要翻译： 本文提供了Tocol衍生物化合物，包含这些衍生物的组合物和使用该衍生物的方法。 具体地，该醇衍生物具有部分不饱和的烃尾，因此与生育酚不同。 碳氢化合物尾料在烃尾部的第二异戊二烯单元中不具有反式碳 - 碳双键，并且与生育三烯酚不同。 预期这些化合物可以比生育三烯酚改善与α-生育酚转移蛋白受体的相互作用，并且比生育酚更好的生物活性。
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公开(公告)号：US07919525B2
公开(公告)日：2011-04-05
申请号：US10545674
申请日：2004-02-17
IPC分类号： A61K31/355
CPC分类号： A61K9/0019 , A61K31/355 , A61K47/10 , A61K2300/00
摘要： The present invention relates to methods for the prevention and treatment of a mammal from radiation-induced internal injury using γ-tocotrienol, α-tocopherol succinate or γ-tocotrienol succinate. Specifically, the present invention relates to methods for preventing and treating radiation-induced injuries in a mammal by (1) subcutaneous, intramuscular, intraperitoneal, or intravascular injection of a therapeutically effective amount of γ-tocotrienol; or (2) oral administration of a therapeutically effective amount of α-tocopherol succinate or γ-tocotrienol succinate or both.
摘要翻译： 本发明涉及使用γ-生育三烯酚，α-生育酚琥珀酸酯或γ-生育三烯酚琥珀酸酯的辐射诱导的内部损伤来预防和治疗哺乳动物的方法。 具体地，本发明涉及通过（1）皮下，肌内，腹膜内或血管内注射治疗有效量的γ-生育三烯酚来预防和治疗哺乳动物的放射线诱发损伤的方法; 或（2）口服给予治疗有效量的α-生育酚琥珀酸酯或γ-生育三烯酚琥珀酸酯或两者。
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