-
1.发明授权Method for producing or enhancing a T-cell response against a target cell using a complex comprising an HLA class I molecule and an attaching means 失效使用包含HLA I类分子和附着装置的复合物来产生或增强针对靶细胞的T细胞应答的方法公开(公告)号：US07264965B2
公开(公告)日：2007-09-04
申请号：US10116901
申请日：2002-04-05
CPC分类号： C07K14/005 , A61K38/00 , A61K47/6849 , C07K14/70539 , C07K2319/00 , C12N2740/16222
摘要： A complex including an HLA class I molecule and attaching means for selectively attaching the HLA class I molecule to a target is disclosed, and a method is provided for producing or enhancing an immunological response against a target cell, by attaching said complex to the target cell. Where the target cell is diseased, foreign, or malignant cell, this method may be used to promote lysis of the target cell by T cells in the immune system. Where the target cell is an antigen presenting cell, this method may be used to promote proliferation of specific T cell clones. Uses include prevention and treatment of diseases including cancer, leukaemia, infectious diseases, viral infections, such as HIV, bacterial infections, such as tuberculosis, and parasitic infections such as malaria.
摘要翻译： 公开了包括HLA I类分子和用于将HLA I类分子选择性连接到靶的附着装置的复合物，并且提供了通过将所述复合物连接到靶细胞来产生或增强针对靶细胞的免疫应答的方法 。 靶细胞是患病，外源或恶性细胞时，该方法可用于促进免疫系统中的T细胞对靶细胞的裂解。 当靶细胞是抗原呈递细胞时，该方法可用于促进特异性T细胞克隆的增殖。 用途包括预防和治疗包括癌症，白血病，传染病，艾滋病病毒感染，细菌感染如结核病以及寄生虫感染如疟疾在内的疾病。
-
公开(公告)号：US07521197B2
公开(公告)日：2009-04-21
申请号：US10308543
申请日：2002-12-03
CPC分类号： C07K14/005 , A61K38/00 , A61K47/6849 , C07K14/70539 , C07K2319/00 , C12N2740/16222
摘要： The invention relates to the method for producing antipeptide cytotoxic T lymphocytes (CTLs) by attaching a complex of a class I HLA and a peptide to antigen presenting cell(s) (APCs) present in a sample of peripheral blood lymphocytes (PBLs), optionally removing excess class I HLA/peptide complex, and incubating with proliferative cytokine. The invention further relates to a CTL obtainable by these methods and to a method of treating a subject by administering such a CTL to the subject.
摘要翻译： 本发明涉及通过将I类HLA和肽的复合物附着在存在于外周血淋巴细胞（PBL）样品中的抗原呈递细胞（APC）上，任选地产生抗肽细胞毒性T淋巴细胞（CTL）的方法 去除过量的I类HLA /肽复合物，并与增殖细胞因子一起孵育。 本发明还涉及通过这些方法获得的CTL和通过向受试者施用这样的CTL来治疗受试者的方法。
-
3.发明授权Method for producing or enhancing a T-cell response against a target cell using a complex comprising an HLA class I molecule and an attaching means 失效使用包含HLA I类分子和附着装置的复合物来产生或增强针对靶细胞的T细胞应答的方法公开(公告)号：US07268219B1
公开(公告)日：2007-09-11
申请号：US09724985
申请日：2000-11-28
CPC分类号： C07K14/005 , A61K38/00 , A61K47/6849 , C07K14/70539 , C07K2319/00 , C12N2740/16222
摘要： A complex comprising an HLA Class 1 molecule and attaching means for selectively attaching the HLA class 1 molecule to a target cell is disclosed, and a method is provided for producing or enhancing an immunological response against a target cell, by attaching said complex to the target cell. Where the target is a diseased, foreign or malignant cell, this method may be used to promote the lysis of the targeted cell by T cells in the immune system. Where the target cell is an antigen presenting cell, this method may be used to promote the proliferation of specific T cell clones. The invention is of potential use in the prevention and treatment of malignant diseases including cancer and leukemia, infectious diseases including viral infections such as HIV, bacterial infections including tuberculosis, and parasitic infections including malaria.
摘要翻译： 公开了一种包含HLA 1类分子和用于将HLA 1类分子选择性连接到靶细胞的附着装置的复合物，并且提供了通过将所述复合物连接到靶标来产生或增强针对靶细胞的免疫应答的方法 细胞。 目标是患病的外来或恶性细胞时，该方法可用于促进免疫系统中T细胞对靶细胞的裂解。 当靶细胞是抗原呈递细胞时，该方法可用于促进特异性T细胞克隆的增殖。 本发明可用于预防和治疗包括癌症和白血病在内的恶性疾病，包括艾滋病病毒感染在内的感染性疾病，包括结核病在内的细菌感染和包括疟疾在内的寄生虫感染。
-
-
搜索结果
3 条记录 (耗时 0.015 秒)
