公开(公告)号：US06551781B1

公开(公告)日：2003-04-22

申请号：US09614957

申请日：2000-07-12

申请人： Philippe Gros ,  Emil Skamene ,  Danielle Malo ,  Silvia Vidal

发明人： Philippe Gros ,  Emil Skamene ,  Danielle Malo ,  Silvia Vidal

IPC分类号： C12Q168

CPC分类号： C07K14/47 ,  C12N15/11

摘要： The present invention relates to mouse and human cDNAs for a gene family designated Nramp (natural resistance-associated macrophage protein), involved in macrophage function and responsible for the natural resistance to infection with intracellular parasites, and to the isolation of Nramp sequences from other animal sources. The nucleotide sequences of the mouse and human cDNAs are disclosed, as are the amino sequences of the encoded products. The cDNAs can be expressed in expression constructs. These expression constructs and the proteins produced therefrom can be used for a variety of purposes including diagnostic and therapeutic methods.

摘要翻译： 本发明涉及涉及巨噬细胞功能并负责天然抗细胞内寄生虫感染的Nramp（天然抗性相关巨噬细胞蛋白）的基因家族的小鼠和人类cDNA，以及从其他动物分离Nramp序列 来源。 公开了小鼠和人cDNA的核苷酸序列，以及编码产物的氨基序列。 cDNA可以在表达构建体中表达。 这些表达构建体和由其产生的蛋白质可以用于各种目的，包括诊断和治疗方法。

公开(公告)号：US06184031B2

公开(公告)日：2001-02-06

申请号：US08637823

申请日：1996-05-08

申请人： Philippe Gros ,  Emil Skamene ,  Danielle Malo ,  Silvia Vidal

发明人： Philippe Gros ,  Emil Skamene ,  Danielle Malo ,  Silvia Vidal

IPC分类号： C07H2104

CPC分类号： C07K14/47 ,  C12N15/11

摘要： The present invention relates to mouse and human cDNAs for a gene family designated Nramp (natural resistance-associated macrophage protein), involved in macrophage function and responsible for the natural resistance to infection with intracellular parasites, and to the isolation of Nramp sequences from other animal sources. The nucleotide sequences of the mouse and human cDNAs are disclosed, as are the amino sequences of the encoded products. The cDNAs can be expressed in expression constructs. These expression constructs and the proteins produced therefrom can be used for a variety of purposes including diagnostic and therapeutic methods.

摘要翻译： 本发明涉及涉及巨噬细胞功能并负责天然抗细胞内寄生虫感染的Nramp（天然抗性相关巨噬细胞蛋白）的基因家族的小鼠和人类cDNA，以及从其他动物分离Nramp序列 来源。 公开了小鼠和人cDNA的核苷酸序列，以及编码产物的氨基序列。 cDNA可以在表达构建体中表达。 这些表达构建体和由其产生的蛋白质可以用于各种目的，包括诊断和治疗方法。