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    Anthelmintic dysinins of marine origin
    1.
    发明授权
    Anthelmintic dysinins of marine origin 失效
    海洋起源的驱虫虫排毒素

    公开(公告)号：US4943589A

    公开(公告)日：1990-07-24

    申请号：US263261

    申请日：1988-10-27

    申请人： Phillip Crews ,  Thomas R. Matthews ,  Paul Horton

    发明人： Phillip Crews ,  Thomas R. Matthews ,  Paul Horton

    IPC分类号： A61K31/34 ,  C07D307/92

    CPC分类号： C07D307/92 ,  A61K31/34

    摘要： This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R.sup.1 is hydrogen or --SR.sup.2, whereinR.sup.2 is hydrogen, --C(O)--CH.sub.3, or ##STR2## or a pharmaceutically acceptable salt thereof. This invention is also directed to a composition for treating helminthiasis in an animal which comprises a pharmaceutically acceptable excipient and an anthelmintically effective amount of a compound of Formula (I). This invention is also directed to novel compounds of Formula (I) wherein R.sup.2 is ##STR3##

    摘要翻译： 本发明涉及一种治疗蠕虫病的方法，其包括向有需要的动物施用驱肠成形有效量的式（I）化合物：其中R 1为氢或-SR 2，其中R 2为氢 ，-C（O）-CH 3或其药学上可接受的盐。 本发明还涉及用于治疗动物中的蠕虫病的组合物，其包含药学上可接受的赋形剂和驱肠虫有效量的式（I）化合物。 本发明还涉及式（I）的新化合物，其中R 2是

    Alkaloids of marine origin
    2.
    发明授权
    Alkaloids of marine origin 失效
    海洋来源的生物碱

    公开(公告)号：US4959370A

    公开(公告)日：1990-09-25

    申请号：US330164

    申请日：1989-03-29

    申请人： Phillip Crews ,  Thomas R. Matthews ,  Wayne D. Inman

    发明人： Phillip Crews ,  Thomas R. Matthews ,  Wayne D. Inman

    IPC分类号： C07D471/16

    CPC分类号： C07D471/16

    摘要： This invention is directed to novel compounds of Formula (I): ##STR1## wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof and pharmaceutical compositions formulated therewith. This invention is also directed to a method for treating helminthiasis and for inhibiting reverse transcriptase activity in an animal by the administration of compounds of Formula (I).

    摘要翻译： 本发明涉及式（I）的新化合物：其中R是氢或甲基，或其药学上可接受的盐和与其配制的药物组合物。 本发明还涉及通过给予式（I）化合物来治疗蠕虫病和用于抑制动物体内逆转录酶活性的方法。

    Gutter cleaner
    6.
    发明授权
    Gutter cleaner 失效
    沟槽清洁剂

    公开(公告)号：US4930824A

    公开(公告)日：1990-06-05

    申请号：US345349

    申请日：1989-04-28

    申请人： Thomas R. Matthews ,  Garland B. Ricketts

    发明人： Thomas R. Matthews ,  Garland B. Ricketts

    IPC分类号： B25J1/04 ,  E04D13/076

    CPC分类号： E04D13/0765 ,  B25J1/04

    摘要： A gutter cleaner for remotely cleaning an overhead gutter or the like which includes an elongate handle, a pair of cooperating fork-like jaws mounted at the upper end of the handle, and a sleeve slidably mounted on the lower end of the handle for selectively opening and closing the fork-like jaws. The jaws include a stationary first jaw and a relatively pivotably movable second jaw which each have a greater width than height so that the jaws may be placed in a gutter extending in a direction lengthwise with the gutter. In this manner a substantial length of the gutter may be cleaned of collected debris with each application of the gutter cleaner thereto.

    摘要翻译： 一种用于远程清洁顶盖槽等的沟槽清洁器，其包括细长手柄，安装在手柄上端的一对配合的叉形夹爪以及可滑动地安装在手柄下端上的套筒，用于选择性地打开 并关闭叉状夹爪。 夹爪包括固定的第一颚和相对可枢转的第二颚，每个颚具有比高度更大的宽度，使得颚可以放置在沿沟槽纵向延伸的沟槽中。 以这种方式，每个施加沟槽清洁器可以清除大量的沟槽，以收集收集的碎屑。

    Bengamide anthelmintics
    7.
    发明授权
    Bengamide anthelmintics 失效
    孟加拉胺驱虫药

    公开(公告)号：US4831135A

    公开(公告)日：1989-05-16

    申请号：US875486

    申请日：1986-06-18

    申请人： Philip Crews ,  Thomas R. Matthews ,  Emilio Quinoa ,  Madeline Adamczeski

    发明人： Philip Crews ,  Thomas R. Matthews ,  Emilio Quinoa ,  Madeline Adamczeski

    IPC分类号： C07D223/12

    CPC分类号： C07D223/12

    摘要： Novel .delta.-caprolactam derivatives of formula I have anti-tumor, antibiotic and anthelmintic activity: ##STR1## wherein: R is H, lower alkyl, or lower acyl;R.sub.1, R.sub.2, and R.sub.3 are each independently H or lower acyl;R.sub.4 is H or acyl of 1 to 22 carbon atoms;R.sub.5 is H or lower acyl;R.sub.6 and R.sub.7 are each H or OH, or R.sub.6 and R.sub.7 together form an epoxide or a double bond;and the pharmaceutically acceptable salts thereof.

    摘要翻译： 式I的新型三 - 己内酰胺衍生物具有抗肿瘤，抗生素和驱肠虫活性：其中：R为H，低级烷基或低级酰基; R1，R2和R3各自独立地为H或低级酰基; R4是H或1〜22个碳原子的酰基; R5是H或低级酰基; R6和R7各自为H或OH，或R6和R7一起形成环氧化物或双键; 及其药学上可接受的盐。