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公开(公告)号：US06750247B2
公开(公告)日：2004-06-15
申请号：US10159772
申请日：2002-05-31
申请人： Phillip Crews , Jennifer Carroll , Theodore Holman , Guy Miller , Steve Bobzin , Lesley Brown
发明人： Phillip Crews , Jennifer Carroll , Theodore Holman , Guy Miller , Steve Bobzin , Lesley Brown
IPC分类号： A61K3119
CPC分类号： A61K31/355 , A61K31/192 , A61K31/255 , A61K31/335 , A61K31/34 , A61K31/35 , A61K31/353 , A61K31/365
摘要： Compounds that are effective lipoxygenase inhibitors, and methods and pharmaceutical compositions for inhibiting lipoxygenases and for treatment of lipoxygenase-mediated conditions in humans and other subjects. The compounds, methods and pharmaceutical compositions utilize subersic terpenoids, jaspic terpenoids, igernellic terpenoids, hippospongic terpenoids, halicondric terpenoids, dictyodendric terpenoids, and/or heteronemic terpenoids, and synthetic derivatives or analogs thereof. Exemplary compounds include (−)-subersic acid, (+)-subersin, jaspaquinol, (−)-jaspic acid, igernellin, halisufate 7, and hipposulfate C and D, and derivatives thereof.
摘要翻译： 作为有效的脂氧合酶抑制剂的化合物，以及用于抑制脂氧合酶和用于治疗人和其他受试者中脂氧合酶介导的病症的方法和药物组合物。 化合物，方法和药物组合物利用萜类化合物，ic萜类化合物，igernellic萜类化合物，髋关节萜类化合物，卤代萜类化合物，二萜类萜类化合物和/或异源萜类化合物，及其合成衍生物或类似物。 示例性化合物包括（ - ） - subersic acid，（+） - subersin，jaspaquinol，（ - ） - jaspic acid，igernellin，halisufate 7和河pos啶C和D及其衍生物。
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公开(公告)号：US20210221777A1
公开(公告)日：2021-07-22
申请号：US17149203
申请日：2021-01-14
申请人： Tyler A. Johnson , Colon V. Cook , Nicole L. McIntosh , Joseph D. Morris , Frederick A. Valeriote , JiaJiu Shaw , Phillip Crews , Mani Maheshwari
发明人： Tyler A. Johnson , Colon V. Cook , Nicole L. McIntosh , Joseph D. Morris , Frederick A. Valeriote , JiaJiu Shaw , Phillip Crews , Mani Maheshwari
IPC分类号： C07D277/30 , A61P35/00
摘要： A pharmaceutically active mycathiozole analog or salt thereof is derived from naturally occurring mycathiozole. The analog or salt is useful in cancer treatment.
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公开(公告)号：US5607741A
公开(公告)日：1997-03-04
申请号：US351624
申请日：1994-12-08
IPC分类号： A01N31/08 , A01N41/02 , C07C303/44 , C07C305/24 , C09D5/16 , C09D7/12 , H01R12/18 , H01R13/193 , H01R24/00 , B32B9/04
CPC分类号： A01N41/02 , Y10S428/907 , Y10T428/23 , Y10T428/31504 , Y10T428/8305
摘要： p-Sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-Sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.
摘要翻译： 从具有显着防污水生性能的鳗鱼Zostera码头的甲醇提取物中分离出的对磺基肉桂酸。 在实验室中由对香豆酸合成对磺基肉桂酸，实验室生物测定中防污活性与天然化合物相同。 此外，其他酚酸的硫酸酯表现出相似的防污性能，表明硫酸酯是造成防污效果的原因。
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公开(公告)号：US5384176A
公开(公告)日：1995-01-24
申请号：US989274
申请日：1992-12-11
IPC分类号： A01N31/08 , A01N41/02 , C07C303/44 , C07C305/24 , C09D5/16 , C09D7/12 , H01R12/18 , H01R13/193 , H01R24/00 , B32B9/04
CPC分类号： A01N41/02 , Y10S428/907 , Y10T428/23 , Y10T428/31504 , Y10T428/8305
摘要： p-sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.
摘要翻译： 从具有显着防污水生性质的鳗鱼Zostera码头的甲醇提取物中分离的对 - 磺基氧肉桂酸。 在实验室从对香豆酸合成了对磺基肉桂酸，实验室生物测定中防污活性与天然化合物相同。 此外，其他酚酸的硫酸酯表现出相似的防污性能，表明硫酸酯是造成防污效果的原因。
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公开(公告)号：US4959370A
公开(公告)日：1990-09-25
申请号：US330164
申请日：1989-03-29
IPC分类号： C07D471/16
CPC分类号： C07D471/16
摘要： This invention is directed to novel compounds of Formula (I): ##STR1## wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof and pharmaceutical compositions formulated therewith. This invention is also directed to a method for treating helminthiasis and for inhibiting reverse transcriptase activity in an animal by the administration of compounds of Formula (I).
摘要翻译： 本发明涉及式（I）的新化合物：其中R是氢或甲基，或其药学上可接受的盐和与其配制的药物组合物。 本发明还涉及通过给予式（I）化合物来治疗蠕虫病和用于抑制动物体内逆转录酶活性的方法。
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公开(公告)号：US4943589A
公开(公告)日：1990-07-24
申请号：US263261
申请日：1988-10-27
申请人： Phillip Crews , Thomas R. Matthews , Paul Horton
发明人： Phillip Crews , Thomas R. Matthews , Paul Horton
IPC分类号： A61K31/34 , C07D307/92
CPC分类号： C07D307/92 , A61K31/34
摘要： This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R.sup.1 is hydrogen or --SR.sup.2, whereinR.sup.2 is hydrogen, --C(O)--CH.sub.3, or ##STR2## or a pharmaceutically acceptable salt thereof. This invention is also directed to a composition for treating helminthiasis in an animal which comprises a pharmaceutically acceptable excipient and an anthelmintically effective amount of a compound of Formula (I). This invention is also directed to novel compounds of Formula (I) wherein R.sup.2 is ##STR3##
摘要翻译： 本发明涉及一种治疗蠕虫病的方法，其包括向有需要的动物施用驱肠成形有效量的式（I）化合物：其中R 1为氢或-SR 2，其中R 2为氢 ，-C（O）-CH 3或其药学上可接受的盐。 本发明还涉及用于治疗动物中的蠕虫病的组合物，其包含药学上可接受的赋形剂和驱肠虫有效量的式（I）化合物。 本发明还涉及式（I）的新化合物，其中R 2是
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