公开(公告)号：US07405826B2

公开(公告)日：2008-07-29

申请号：US11168295

申请日：2005-06-29

Applicant: Phillip R. Gibbs ,  Jason D. Beebe

Inventor： Phillip R. Gibbs ,  Jason D. Beebe

IPC: G01N21/00 ,  G01J4/00

CPC classification number: G01J3/2803 ,  G01N21/1717 ,  G01N21/21 ,  G01N2021/218

Abstract: An apparatus and method for improved detection of a chiral property of a sample begins with a probe beam of light having a first modulation frequency ω and is further modulated with a second modulation frequency φ. A non-linear photo-detector, which may include multiple detector portions to form a balanced receiver, mixes the first modulation with the second modulation to analyze frequency components at inter-modulated sidebands, where the level of the inter-modulated sidebands are related to the chiroptical property of the sample. The inter-modulated sidebands may be the additive sidebands or the subtractive sidebands. A lock-in detector can be used to receive a signal output from the non-linear photo-detector and generate the modulation signals at the different modulating frequencies. Furthermore, the non-linear photo-detector may analyze a ratio of the inter-modulated sideband levels, such as (φ+2ω)/(φ+ω), to yield a signal that is linearly related to the chiral property of the sample.

Abstract translation: 用于改进样品手性性质检测的装置和方法以具有第一调制频率ω的探测光束开始，并且用第二调制频率phi进一步调制。 可以包括多个检测器部分以形成平衡接收器的非线性光检测器将第一调制与第二调制混合，以分析调制后边带处的频率分量，其中互调侧边带的电平与 样本的手性属性。 相互调制的边带可以是加性边带或减法边带。 锁定检测器可用于接收来自非线性光电检测器的信号输出，并产生不同调制频率的调制信号。 此外，非线性光检测器可以分析诸如（phi + 2omega）/（phi +ω）之间的调制调制边带等级的比率，以产生与样品的手性特征线性相关的信号 。