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公开(公告)号：US10822628B2
公开(公告)日：2020-11-03
申请号：US15100780
申请日：2014-12-02
申请人： Phyton Holdings, LLC
发明人： Gilbert Gorr , Harald Heckenmüller , David Alexander Ullisch , Jens Stefan Wilke , Yantree Devi Sankar-Thomas
摘要： The present invention relates to a method of producing sesquiterpene lactones of the thapsigargin family, the method comprising the steps of: (a) culturing plant cells of the genus Thapsia in a nutrient medium in a suspension cell culture, wherein the cells produce one or more sesquiterpene lactones of the thapsigargin family; and (b) recovering one or more sesquiterpene lactones of the thapsigargin family produced in (a). The present invention further relates to a suspension cell culture comprising plant cells of the genus Thapsia, wherein the plant cells are capable of producing one or more sesquiterpene lactones of the thapsigargin family and to a plant cell biomass comprising plant cells of the genus Thapsia obtained from said suspension cell culture.
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2.发明申请公开(公告)号：US20160312255A1
公开(公告)日：2016-10-27
申请号：US15100780
申请日：2014-12-02
申请人： PHYTON HOLDINGS, LLC
发明人： Gilbert Gorr , Harald Heckenmuller , David Alexander Ullisch , Jens Stefan Wilke , Yantree Devi Sankar-Thomas
摘要： The present invention relates to a method of producing sesquiterpene lactones of the thapsigargin family, the method comprising the steps of: (a) culturing plant cells of the genus Thapsia in a nutrient medium in a suspension cell culture, wherein the cells produce one or more sesquiterpene lactones of the thapsigargin family; and (b) recovering one or more sesquiterpene lactones of the thapsigargin family produced in (a). The present invention further relates to a suspension cell culture comprising plant cells of the genus Thapsia, wherein the plant cells are capable of producing one or more sesquiterpene lactones of the thapsigargin family and to a plant cell biomass comprising plant cells of the genus Thapsia obtained from said suspension cell culture.
摘要翻译： 本发明涉及一种生产沙皮菌素家族的倍半萜内酯的方法，该方法包括以下步骤：（a）在悬浮细胞培养物中培养营养培养基中的Thapsia属植物细胞，其中细胞产生一种或多种 麻醉药物家族的倍半萜内酯; 和（b）回收（a）中生产的沙皮加球蛋白家族中的一种或多种倍半萜内酯。 本发明还涉及包含Thapsia属植物细胞的悬浮细胞培养物，其中植物细胞能够产生一种或多种thapsigargin家族的倍半萜内酯，以及一种植物细胞生物质，其包含从Thapsia属的植物细胞获得， 所述悬浮细胞培养。
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公开(公告)号：US10172306B2
公开(公告)日：2019-01-08
申请号：US15559565
申请日：2016-03-18
申请人： Phyton Holdings, LLC
发明人： Gilbert Gorr , David Alexander Ullisch , Yantree Devi Sankar-Thomas , Thomas Selge , Thomas Leibold , Harald Heckenmüller
摘要： The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives.
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4.发明申请公开(公告)号：US20180042194A1
公开(公告)日：2018-02-15
申请号：US15559565
申请日：2016-03-18
申请人： Phyton Holdings, LLC
发明人： Gilbert Gorr , David Alexander Ullisch , Yantree Devi Sankar-Thomas , Thomas Selge , Thomas Leibold , Harald Heckenmüller
CPC分类号： A01H4/001 , A61K36/47 , C12N5/0025 , C12N5/04
摘要： The present invention relates to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives, the method comprising the steps of: (a) culturing plant cells obtained from a plant selected from the family Euphorbiaceae in a nutrient medium in a suspension cell culture, wherein the cells produce Ingenol, one or more Ingenol esters and/or one or more Tiglian-3-one derivatives; and (b) recovering the Ingenol, the one or more Ingenol esters and/or the one or more Tiglian-3-one derivatives produced in (a). The present invention further relates to a plant suspension cell culture, wherein the cells are obtained from a plant selected from the family Euphorbiaceae, and wherein the plant cells produce Ingenol and/or one or more Ingenol ester and/or one or more Tiglian-3-one derivatives. The present invention further relates to a plant cell biomass comprising plant cells obtained from the suspension cell culture of the invention, and comprising Ingenol and/or one or more Ingenol esters and/or one or more Tiglian-3-one derivatives. Also, the present invention relates to cryopreserved cells of the plant suspension cell culture of the invention as well as to a method of producing Ingenol, Ingenol esters and/or Tiglian-3-one derivatives based on these cryopreserved cells.
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