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1.发明申请Novel Oxadiazole Derivatives and Their Use as Positive Allosteric Modulators of Metabotropic Glutamate Receptors 审中-公开新型恶二唑衍生物及其作为代谢型谷氨酸受体的正变构调节剂公开(公告)号：US20090197897A1
公开(公告)日：2009-08-06
申请号：US11920489
申请日：2006-05-17
申请人： Piergiuliano Bugada , Stefania Gagliardi , Emmanuel Le Poul , Vincent Mutel , Giovanni Palombi , Jean-Philippe Rocher
发明人： Piergiuliano Bugada , Stefania Gagliardi , Emmanuel Le Poul , Vincent Mutel , Giovanni Palombi , Jean-Philippe Rocher
IPC分类号： C07D413/14 , C07D413/02 , A61K31/4439 , A61K31/497 , A61P25/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to new compounds which are Oxadiazole derivatives of formula (I) wherein B, P, Q, W, R1 and R2 are defined in the description. Invention compounds are useful in the prevention or treatment of central or peripheral nervous system disorders as well as other disorders modulated by mGluR5 receptors.
摘要翻译： 本发明涉及新的化合物，其是式（I）的恶二唑衍生物，其中B，P，Q，W，R 1和R 2在说明书中定义。 本发明化合物可用于预防或治疗中枢或周围神经系统疾病以及由mGluR5受体调节的其它病症。
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2.发明申请Carbamate derivatives as positive allosteric modulators of metabotropic glutamate receptors 审中-公开氨基甲酸酯衍生物作为代谢型谷氨酸受体的正变构调节剂公开(公告)号：US20090082399A1
公开(公告)日：2009-03-26
申请号：US11920616
申请日：2006-05-17
IPC分类号： A61K31/4545 , C07D211/42 , C07D401/12 , A61K31/40 , C07D207/12 , A61K31/445
CPC分类号： C07D295/192 , C07D207/12 , C07D211/42 , C07D211/56 , C07D401/12
摘要： The present invention relates to new compounds which are Carbamate derivatives of formula I wherein X, B, P, Q5W, R1 and R2 are defined in the description. Invention compounds are useful for treating CNS or PNS disorders which are affected by the neuromodulatory effect of mGluR5 positive allosteric modulators such as cognitive decline and also to treat both positive and negative symptoms in schizophrenia
摘要翻译： 本发明涉及新的化合物，它们是式I的氨基甲酸酯衍生物，其中X，B，P，Q5W，R 1和R 2在说明书中定义。 本发明化合物可用于治疗受到认知衰退的mGluR5阳性变构调节剂的神经调节作用影响的CNS或PNS病症，并且也用于治疗精神分裂症中的阳性和阴性症状
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