公开(公告)号：US07015048B2

公开(公告)日：2006-03-21

申请号：US10038192

申请日：2002-01-02

Applicant: Pierre Delmas ,  Patrick Garnero ,  Evelyne Gineyts

Inventor： Pierre Delmas ,  Patrick Garnero ,  Evelyne Gineyts

IPC: G01N33/53

CPC classification number: G01N33/6887 ,  G01N33/5308 ,  G01N33/564 ,  G01N2333/78 ,  G01N2800/52 ,  Y10S436/811

Abstract: Disclosed are specific markers for synovial tissue degradation and methods of using the markers in diagnosing, monitoring or determining a prognosis of synovial disease.

Abstract translation: 公开了用于滑膜组织降解的特异性标记物和在诊断，监测或确定滑膜疾病预后中使用标记物的方法。

公开(公告)号：US6004765A

公开(公告)日：1999-12-21

申请号：US442138

申请日：1995-05-16

Applicant: Pierre Delmas

Inventor： Pierre Delmas

IPC: C07K16/44 ,  G01N33/68 ,  C07K16/00 ,  G01N33/53 ,  G01N33/543

CPC classification number: C07K16/44 ,  G01N33/68 ,  G01N33/6893 ,  Y10S435/81 ,  Y10S435/975 ,  Y10S436/808 ,  Y10S436/811

Abstract: A method for the assessment of bone fragility and osteoporosis fracture risk characterized by:measuring in vitro the concentration of under-carboxylated osteocalcin in a biological fluid sample such as serum, plasma or urine;comparing the concentration of under-carboxylated osteocalcin in the test sample with the concentration in a control sample containing levels of under-carboxylated osteocalcin representative of the upper limit of the normal range, concentrations above this upper limit being indicative of increased risk of bone fracture.

Abstract translation: 一种评估骨骼脆性和骨质疏松症骨折风险的方法，其特征在于：在体外测量生物流体样品如血清，血浆或尿液中未羧化的骨钙素的浓度; 将测试样品中未羧化的骨钙素的浓度与含有代表正常范围上限的低羧基化骨钙素含量的对照样品中的浓度进行比较，高于该上限的浓度表示骨折的风险增加。