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1.发明授权Method for the transformation of cells, particularly eukaryotes by a DNA originating from viruses of hepatitis, more particularly from virus of B viral hepatitis, and preparations containing the expression products of said DNAs 失效通过源自肝炎病毒的DNA特别是真核细胞转化细胞的方法，特别是来自B病毒性肝炎病毒的方法以及含有所述DNA的表达产物的制剂
公开(公告)号：US5591638A
公开(公告)日：1997-01-07
申请号：US191133
申请日：1994-01-25
申请人： Pierre Tiollais , Charles Chany , Marie-Fran.cedilla.oise Dubois , Christine Pourcel , Anne Louise
发明人： Pierre Tiollais , Charles Chany , Marie-Fran.cedilla.oise Dubois , Christine Pourcel , Anne Louise
CPC分类号： C07K14/005 , C12N15/85 , A61K39/00 , C12N2730/10122
摘要： Method for the production of antigens vaccinating against the virus of B viral hepatitis. It consists of transforming a cell culture with a vector, more particularly a plasmid, itself containing an insertion sequence including itself at least the part of the viral DNA coding for the immunogen protein, capable of inducing in vivo antibody production active with respect to the whole virus, as well as the viral promoter under the control of which the transcription and translation of the above-said part of viral DNA is normally carried out, in particular in a host infected with the corresponding virus.
摘要翻译： 生产针对B型病毒性肝炎病毒的抗原的方法。 它包括用载体转化细胞培养物，更特别是质粒本身，其含有包含其自身的至少一部分编码免疫原蛋白的病毒DNA的插入序列，其能够引起体内抗体产生相对于整体的活性 病毒以及病毒启动子，其中病毒启动子的上述部分病毒DNA的转录和翻译通常进行，特别是在感染了相应病毒的宿主中。
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2.发明授权Method for the transformation of cells, particularly eukaryotes by a DNA originating from viruses of hepatitis, more particularly from virus of a B viral hepatitis, and preparations containing the expression products of said DNAs 失效通过源自肝炎病毒的DNA特别是真核细胞转化细胞的方法，特别是来自B病毒性肝炎的病毒，以及含有所述DNA的表达产物的制剂
公开(公告)号：US5314808A
公开(公告)日：1994-05-24
申请号：US482322
申请日：1983-04-05
CPC分类号： C07K14/005 , C12N15/85 , A61K39/00 , C12N2730/10122
摘要： Method for the production of antigens vaccinating against the virus of B viral hepatitis. It consists of transforming a cell culture with a vector, more particularly a plasmid, itself containing an insertion sequence including itself at least the part of the viral DNA coding for the immunogen protein, capable of inducing in vivo antibody production active with respect to the whole virus, as well as the viral promoter under the control of which the transcription and translation of the above-said part of viral DNA is normally carried out, in particular in a host infected with the corresponding virus.
摘要翻译： 生产针对B型病毒性肝炎病毒的抗原的方法。 它包括用载体转化细胞培养物，更特别是质粒本身，其含有包含其自身的至少一部分编码免疫原蛋白的病毒DNA的插入序列，其能够引起体内抗体产生相对于整体的活性 病毒以及病毒启动子，其中病毒启动子的上述部分病毒DNA的转录和翻译通常进行，特别是在感染了相应病毒的宿主中。
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