公开(公告)号：US06984744B2

公开(公告)日：2006-01-10

申请号：US10721038

申请日：2003-11-21

申请人： Piotr Osinski ,  Kazimierz Michal Pietrusiewicz ,  Rudolf Schmid

发明人： Piotr Osinski ,  Kazimierz Michal Pietrusiewicz ,  Rudolf Schmid

IPC分类号： C07F15/00 ,  C07F9/02 ,  C23C37/00 ,  C07C5/03

CPC分类号： C07B53/00 ,  C07F9/65683 ,  C07F9/65685 ,  C07F15/0073

摘要： The invention is concerned with new phosphine ligands of formula I wherein R1 and R2 are independently of each other unsubstituted alkyl, aryl, cycloalkyl or heteroaryl, or alkyl, aryl, cycloalkyl or heteroaryl each of which independently is substituted by alkyl, alkoxy, halogen, hydroxy, amino, mono- or dialkylamino, aryl, —SO2—R7, —SO3−, —CO—NR8R8′, carboxy, alkoxycarbonyl, trialkylsilyl, diarylalkylsilyl, dialkylarylsilyl or triarylsilyl; R3 is alkyl, cycloalkyl, aryl or heteroaryl; R4′ and R4 are independently of each other hydrogen, alkyl or optionally substituted aryl; or R4′ and R4 together with the C-atom they are attached, form a 3-8-membered carbocyclic ring; dotted line is optionally a double bond; R5 and R6 are independently of each other hydrogen, alkyl or aryl, R7 is alkyl or aryl; and R8 and R8′ are independently of each other hydrogen, alkyl or aryl; the substituents attached by the bold bonds are in cis relation to each other; metal complexes with such ligands in asymmetric reactions.

摘要翻译： 本发明涉及式I的新的膦配体，其中R 1和R 2彼此独立地为未取代的烷基，芳基，环烷基或杂芳基，或烷基，芳基， 环烷基或杂芳基，其各自独立地被烷基，烷氧基，卤素，羟基，氨基，一或二烷基氨基，芳基，-SO 2 -R 7，-SO 3 -CO-NR 8 R 8，羧基，烷氧基羰基，三烷基甲硅烷基，二芳基烷基甲硅烷基，二烷基芳基甲硅烷基或二芳基烷基甲硅烷基 三芳基甲硅烷基 R 3是烷基，环烷基，芳基或杂芳基; R 4'和R 4彼此独立地为氢，烷基或任选取代的芳基; 或R 4'和R 4与它们所连接的C原子一起形成3-8元碳环; 虚线可选地是双键; R 5和R 6彼此独立地为氢，烷基或芳基，R 7为烷基或芳基; R 8和R 8'彼此独立地为氢，烷基或芳基; 通过粗体键连接的取代基彼此成顺式关系; 与不对称反应中的这种配体的金属络合物。