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公开(公告)号:US20200277304A1
公开(公告)日:2020-09-03
申请号:US16818512
申请日:2020-03-13
发明人: Vladimir CMILJANOVIC , Paul HEBEISEN , Florent BEAUFILS , Thomas BOHNACKER , Denise RAGEOT , Alexander SELE , Matthias WYMANN , Jean-Baptiste LANGLOIS
IPC分类号: C07D498/08 , A61K31/53 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D239/48 , C07D491/048 , C07D491/056 , C07D491/20 , C07D519/00 , A61P35/00 , C07D417/14 , C07D491/107 , C07D491/18
摘要: The invention relates to novel phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR) and PI3K-related kinase (PIKKs) inhibitor compounds of formula (I), wherein X1, X2 and X3 are N or CH, with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.
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公开(公告)号:US20190031682A1
公开(公告)日:2019-01-31
申请号:US15525779
申请日:2015-11-10
发明人: Vladimir CMILJANOVIC , Paul HEBEISEN , Florent BEAUFILS , Thomas BOHNACKER , Denise RAGEOT , Alexander SELE , Matthias WYMANN , Jean-Baptiste LANGLOIS
IPC分类号: C07D498/08 , C07D413/14 , C07D417/14 , C07D491/048 , C07D491/056 , C07D491/107 , C07D491/18 , A61P35/00
摘要: The invention relates to novel phosphoinositide 3-kinase (PI3k), mammalian target of rapamycin (mTOR) and PI3k-related kinase (PIKKs) inhibitor compounds of formula (I), wherein X1, X2 and X3 are N or CH, with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.
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公开(公告)号:US20220153752A1
公开(公告)日:2022-05-19
申请号:US17499048
申请日:2021-10-12
申请人: TORQUR AG , UNIVERSITÄT BASEL
发明人: Vladimir CMILJANOVIC , Paul HEBEISEN , Florent BEAUFILS , Thomas BOHNACKER , Denise RAGEOT , Alexander SELE , Matthias WYMANN , Jean-Baptiste LANGLOIS
IPC分类号: C07D498/08 , A61K31/53 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D239/48 , C07D491/048 , C07D491/056 , C07D491/20 , C07D519/00 , A61P35/00 , C07D417/14 , C07D491/107 , C07D491/18
摘要: The invention relates to novel phosphoinositide 3-kinase (PI3K), mammalian target of rapamycin (mTOR) and PI3K-related kinase (PIKKs) inhibitor compounds of formula (I), wherein X1, X2 and X3 are N or CH, with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH, These compounds are useful, either alone or in combination with further therapeutic agents, for treating disorders mediated by lipid kinases.
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