公开(公告)号：US08648800B2

公开(公告)日：2014-02-11

申请号：US13357181

申请日：2012-01-24

申请人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

发明人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

IPC分类号： G09G5/00

CPC分类号： G06F3/015

摘要： A control method of a brain computer interface (BCI) with a stepping delay flickering sequence is provided. First, a plurality of different flickering sequence signals are generated by encoding a static flashing segment and a plurality of stepping delay flashing segments divided in different time sequences. Then, a plurality of target images corresponding to the flickering sequence signals are displayed. Thereafter, a response signal generated by an organism evoked by the target images is acquired. Then, signal processing is performed on the response signal by using a mathematic method to distinguish which one of the target images is gazed by the organism. Thereafter, a controlling command corresponding to one of the target images is generated. A control system of a BCI with a stepping delay flickering sequence is also provided herein.

摘要翻译： 提供了具有步进延迟闪烁序列的脑机接口（BCI）的控制方法。 首先，通过对以不同时间序列分割的静态闪烁段和多个步进延迟闪烁段进行编码来生成多个不同的闪烁序列信号。 然后，显示与闪烁序列信号对应的多个目标图像。 此后，获取由目标图像诱发的生物体产生的响应信号。 然后，通过使用数学方法对响应信号进行信号处理，以区分目标图像中哪一个被生物体凝视。 此后，生成与目标图像之一对应的控制命令。 本文还提供了具有步进延迟闪烁序列的BCI控制系统。

公开(公告)号：US20130100010A1

公开(公告)日：2013-04-25

申请号：US13357181

申请日：2012-01-24

申请人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

发明人： Po-Lei Lee ,  Kuo-Kai Shyu ,  Hsiang-Chih Chang

IPC分类号： G06F3/01

CPC分类号： G06F3/015

摘要： A control method of a brain computer interface (BCI) with a stepping delay flickering sequence is provided. First, a plurality of different flickering sequence signals are generated by encoding a static flashing segment and a plurality of stepping delay flashing segments divided in different time sequences. Then, a plurality of target images corresponding to the flickering sequence signals are displayed. Thereafter, a response signal generated by an organism evoked by the target images is acquired. Then, signal processing is performed on the response signal by using a mathematic method to distinguish which one of the target images is gazed by the organism. Thereafter, a controlling command corresponding to one of the target images is generated. A control system of a BCI with a stepping delay flickering sequence is also provided herein.

摘要翻译： 提供了具有步进延迟闪烁序列的脑机接口（BCI）的控制方法。 首先，通过对以不同时间序列分割的静态闪烁段和多个步进延迟闪烁段进行编码来生成多个不同的闪烁序列信号。 然后，显示与闪烁序列信号对应的多个目标图像。 此后，获取由目标图像诱发的生物体产生的响应信号。 然后，通过使用数学方法对响应信号进行信号处理，以区分目标图像中哪一个被生物体凝视。 此后，生成与目标图像之一对应的控制命令。 本文还提供了具有步进延迟闪烁序列的BCI控制系统。

公开(公告)号：US08825564B2

公开(公告)日：2014-09-02

申请号：US13215236

申请日：2011-08-23

申请人： Po-Lei Lee ,  Kuo-Kai Shyu

发明人： Po-Lei Lee ,  Kuo-Kai Shyu

IPC分类号： G06F15/18 ,  A61B5/0482 ,  G06F3/01

CPC分类号： A61B5/0482 ,  G06F3/015

摘要： A visual drive control method with multi-phase encoding includes the following steps. A plurality of flickering sequences are generated by an encoding process according to a reference phase and a plurality of shifting phases divided in time division under at least one phase shift state, then a display unit is driven to display corresponding optical images. An optic nerve of an organism is evoked by the optical images, such that the organism generates a corresponding biological signal. Next, a computation process is performed to a digital biological signal converted from the biological signal to acquire an average captured reference phase and an average captured shifting phase of the digital biological signal. Then, the frequencies and the phase states of the digital biological signal and the flickering sequences are compared to output a corresponding control signal. A visual drive control apparatus with multi-phase encoding is disclosed herein.

摘要翻译： 具有多相编码的视觉驱动控制方法包括以下步骤。 通过根据参考相位的编码处理和在至少一个相移状态下分时划分的多个移相相位产生多个闪烁序列，然后驱动显示单元显示相应的光学图像。 生物体的视神经由光学图像引起，使得生物体产生相应的生物信号。 接下来，对从生物信号转换的数字生物信号进行计算处理，以获取数字生物信号的平均捕获参考相位和平均捕获的移动相位。 然后，比较数字生物信号和闪烁序列的频率和相位状态，输出相应的控制信号。 本文公开了具有多相编码的视觉驱动控制装置。

公开(公告)号：US11534620B2

公开(公告)日：2022-12-27

申请号：US16799714

申请日：2020-02-24

申请人： Po-Lei Lee

发明人： Po-Lei Lee

IPC分类号： A61N2/02 ,  A61N2/00 ,  A61N1/40 ,  G01R33/36

摘要： A magnetic stimulation device having planar coil structure is disclosed. It contains a power supply module, a current control module, a plurality of planar coil modules and a plurality of electrical connection modules. In the planar coil module of the present invention, the coil structure has a flat and thin design and can be modularized. Compared with the existing magnetic stimulation devices, the overall structure of the present invention is light, thin, short, convenient to carry and use, and can be installed on clothing or built in a mobile device to provide a convenient magnetic stimulation treatment.

公开(公告)号：US20050088617A1

公开(公告)日：2005-04-28

申请号：US10695562

申请日：2003-10-27

申请人： Jen-Chuen Hsieh ,  Tzu-Chen Yeh ,  Yu-Te Wu ,  Po-Lei Lee ,  Li-Fen Chen

发明人： Jen-Chuen Hsieh ,  Tzu-Chen Yeh ,  Yu-Te Wu ,  Po-Lei Lee ,  Li-Fen Chen

IPC分类号： A61B5/0484 ,  G06F3/01 ,  A61B3/10

CPC分类号： G06F3/015 ,  A61B5/04842

摘要： In a method and apparatus for visual drive control, a set of flickering images that flicker at the same flicker frequency and that are associated with mutually distinct flicker patterns are simultaneously presented for viewing by an observer. Thereafter, evoked signals produced in the observer's brain are captured, and the flicker pattern having a greatest similarity with the captured evoked signals is determined. Finally, a control signal corresponding to the flicker pattern having the greatest similarity is generated.

摘要翻译： 在用于视觉驱动控制的方法和装置中，同时呈现以相同闪烁频率闪烁并且与相互不同的闪烁图案相关联的一组闪烁图像，以供观察者观看。 此后，捕获在观察者大脑中产生的诱发信号，并且确定与所捕获的诱发信号具有最大相似性的闪烁图案。 最后，产生与相似度最大的闪烁图案对应的控制信号。

公开(公告)号：US20130177661A1

公开(公告)日：2013-07-11

申请号：US13344019

申请日：2012-01-05

申请人： Yi-Lin Chen ,  Hsin-Sheng Tsay ,  Tzong-Der Way ,  Po-Lei Lee ,  Chao-Yuan Yu ,  Chien-Hsu Chen

发明人： Yi-Lin Chen ,  Hsin-Sheng Tsay ,  Tzong-Der Way ,  Po-Lei Lee ,  Chao-Yuan Yu ,  Chien-Hsu Chen

IPC分类号： A61K36/28 ,  A61P29/00

CPC分类号： A61K36/28 ,  A61K2236/30

摘要： Disclosed are a Saussurea involucrate extract, pharmaceutical composition and use thereof for anti-fatigue and anti-aging. In the embodiments of the present invention, a low dose of ethyl acetate fraction of Saussurea involucrate (preferably 30 mg/kg) and Rutin (preferably 30 mg/kg) can inhibit MDA expression level and increase GPx activity. Additionally, both decrease the expression of COX-2, PARP and caspase-3, via downregulation of NF-kappaB, resulting in neuroprotection. Further, syringe feeding of Saussurea involucrate extract is also performed in aging mouse model. In the future, Saussurea involucrate extract of the present invention can be used in neuroprotection, particularly in treatment or prevention of cerebral diseases, nerve diseases, neurodegenerative diseases, chronic neurodegenerative diseases, aging, and fatigue, caused by oxidative injury.

摘要翻译： 公开了一种Saussurea通用提取物，药物组合物及其用于抗疲劳和抗衰老的用途。 在本发明的实施方案中，低剂量的Saussurea比例（优选30mg / kg）和Rutin（优选30mg / kg）的乙酸乙酯级分可以抑制MDA表达水平并增加GPx活性。 另外，通过下调NF-κB，都能降低COX-2，PARP和caspase-3的表达，从而导致神经保护作用。 此外，老化小鼠模型也进行了Saussurea内rate提取物的注射器喂养。 将来，本发明的Saussurea泛酸提取物可用于神经保护，特别是在由氧化损伤引起的脑疾病，神经疾病，神经变性疾病，慢性神经变性疾病，衰老和疲劳的治疗或预防中。

公开(公告)号：US20210260396A1

公开(公告)日：2021-08-26

申请号：US16799714

申请日：2020-02-24

申请人： Po-Lei Lee

发明人： Po-Lei Lee

IPC分类号： A61N2/02 ,  G01R33/36 ,  A61N1/40 ,  A61N2/00

摘要： A magnetic stimulation device having planar coil structure is disclosed. It contains a power supply module, a current control module, a plurality of planar coil modules and a plurality of electrical connection modules. In the planar coil module of the present invention, the coil structure has a flat and thin design and can be modularized. Compared with the existing magnetic stimulation devices, the overall structure of the present invention is light, thin, short, convenient to carry and use, and can be installed on clothing or built in a mobile device to provide a convenient magnetic stimulation treatment.

公开(公告)号：US07338171B2

公开(公告)日：2008-03-04

申请号：US10695562

申请日：2003-10-27

申请人： Jen-Chuen Hsieh ,  Tzu-Chen Yeh ,  Yu-Te Wu ,  Po-Lei Lee ,  Li-Fen Chen

发明人： Jen-Chuen Hsieh ,  Tzu-Chen Yeh ,  Yu-Te Wu ,  Po-Lei Lee ,  Li-Fen Chen

IPC分类号： A61B3/02

CPC分类号： G06F3/015 ,  A61B5/04842

摘要： In a method and apparatus for visual drive control, a set of flickering images that flicker at the same flicker frequency and that are associated with mutually distinct flicker patterns are simultaneously presented for viewing by an observer. Thereafter, evoked signals produced in the observer's brain are captured, and the flicker pattern having a greatest similarity with the captured evoked signals is determined. Finally, a control signal corresponding to the flicker pattern having the greatest similarity is generated.

摘要翻译： 在用于视觉驱动控制的方法和装置中，同时呈现以相同闪烁频率闪烁并且与相互不同的闪烁图案相关联的一组闪烁图像，以供观察者观看。 此后，捕获在观察者大脑中产生的诱发信号，并且确定与所捕获的诱发信号具有最大相似性的闪烁图案。 最后，产生与相似度最大的闪烁图案对应的控制信号。