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8 条记录 (耗时 0.026 秒)

    Non-signal imidazole reagents for mass spectrometry analysis of phosphomonoesters
    4.
    发明授权
    Non-signal imidazole reagents for mass spectrometry analysis of phosphomonoesters 有权
    用于磷钼酸酯质谱分析的非信号咪唑试剂

    公开(公告)号：US08003395B2

    公开(公告)日：2011-08-23

    申请号：US11922732

    申请日：2006-06-21

    申请人： Poguang Wang ,  Guodong Li ,  Roger W. Giese

    发明人： Poguang Wang ,  Guodong Li ,  Roger W. Giese

    IPC分类号： G01N33/00

    CPC分类号： G01N33/6848 ,  C07F9/6506 ,  Y10T436/143333 ,  Y10T436/147777

    摘要： Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-compounds simultaneously.

    摘要翻译： 描述了称为非信号咪唑的分析化学试剂及其用于分析磷酸单酯的主要优点的使用方法。 本发明的方法和化合物为分析含磷单体化合物提供了许多优点，即同时具有高灵敏度和特异性的特征性多分析物检测。

    Non-signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters
    5.
    发明申请
    Non-signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters 有权
    非信号咪唑试剂用于磷酸单酯的质谱分析

    公开(公告)号：US20090215185A1

    公开(公告)日：2009-08-27

    申请号：US11922732

    申请日：2006-06-21

    申请人： Poguang Wang ,  Guodong Li ,  Roger W. Giese

    发明人： Poguang Wang ,  Guodong Li ,  Roger W. Giese

    IPC分类号： G01N33/68 ,  G01N33/50 ,  C07D233/54

    CPC分类号： G01N33/6848 ,  C07F9/6506 ,  Y10T436/143333 ,  Y10T436/147777

    摘要： Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-compounds simultaneously.

    摘要翻译： 描述了称为非信号咪唑的分析化学试剂及其用于分析磷酸单酯的主要优点的使用方法。 本发明的方法和化合物为分析含磷单体化合物提供了许多优点，即同时具有高灵敏度和特异性的特征性多分析物检测。

    Non-Signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters
    7.
    发明申请
    Non-Signal Imidazole Reagents for Mass Spectrometry Analysis of Phosphomonoesters 审中-公开
    非信号咪唑试剂用于磷酸单酯的质谱分析

    公开(公告)号：US20110269968A1

    公开(公告)日：2011-11-03

    申请号：US13184012

    申请日：2011-07-15

    申请人： Poguang Wang ,  Guodong Li ,  Roger W. Geise

    发明人： Poguang Wang ,  Guodong Li ,  Roger W. Geise

    IPC分类号： C07F9/6506 ,  C07D233/61

    CPC分类号： G01N33/6848 ,  C07F9/6506 ,  Y10T436/143333 ,  Y10T436/147777

    摘要： Analytical chemical reagents termed non-signal imidazoles and a method for their use that provide a host of advantages for analysis of phosphomonoesters are described. The method and compounds of the invention provide a host of advantages for the analysis of phosphomonoester-containing compounds, namely characteristic, multi-analyte detection with high sensitivity and specificity of known and unknown phosphomonoester-containing compounds simultaneously.

    摘要翻译： 描述了称为非信号咪唑的分析化学试剂及其用于分析磷酸单酯的主要优点的使用方法。 本发明的方法和化合物提供了用于分析含有含磷单体的化合物的主要优点，即同时具有高灵敏度和特异性的已知和未知的含磷单体化合物的特征性多分析物检测。

    Cationic tags for attomole level detection of analytes by mass spectrometry
    8.
    发明授权
    Cationic tags for attomole level detection of analytes by mass spectrometry 有权

    公开(公告)号：US10161933B2

    公开(公告)日：2018-12-25

    申请号：US16021941

    申请日：2018-06-28

    申请人： Roger Giese ,  Poguang Wang

    发明人： Roger Giese ,  Poguang Wang

    IPC分类号： G01N33/52 ,  G01N24/00 ,  C07C217/58 ,  C07C217/48

    摘要： The invention provides methods of detecting an analyte by multi-stage mass spectrometry with improved S/N ratio. An analyte is labeled with a positively-charged mass tag to form a precursor ion that leads by anchimeric assistance to a greatly enhanced, analyte-characteristic first product ion that can, in turn, lead to a greatly enhanced, analyte-characteristic second product ion in a mass spectrometer. Either a three stage mass spectrometer (true MS3) or a two-stage mass spectrometer (MS2) operated in a pseudo MS3 mode can be used. The precursor ion is split via an anchimeric-assisted reaction to form a first product ion, which in turn can be fragmented to form the second product ion. The methods offer extreme ultrasensitivity, at the low amol level. The invention also provides anchimeric mass tags for use in the methods. A wide variety of previously undetectable analytes of biological or environmental origin can be detected and quantified.