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公开(公告)号：US20220238187A1
公开(公告)日：2022-07-28
申请号：US17616546
申请日：2020-06-03
发明人： Frederic Leblond , Emile Lemoine
摘要： There is described a method of assessing a phenotype of a biological tissue of a patient. The method generally having receiving a Raman emission signal indicative of Raman emission of a portion of said biological tissue; using a feature generator, determining a value of a first feature based on said received Raman emission signal; using a computing device, receiving a value of a clinical parameter associated to the patient; generating a value of a second feature by interacting said value of said first feature with said value of said clinical parameter; using a trained assessment engine, assessing the phenotype of the biological tissue based on at least said value of said second feature; and outputting a signal based on said assessment.
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2.发明公开公开(公告)号：US20240102933A1
公开(公告)日：2024-03-28
申请号：US18382949
申请日：2023-10-23
IPC分类号： G01N21/65
CPC分类号： G01N21/65 , A61B5/0075
摘要： There is described a method for performing a Raman spectroscopy measurement on a sample. The method generally has sequentially illuminating an area of said sample with first and second excitation signals, said first excitation signal being slightly spectrally spaced-apart from said second excitation signal, resulting in said area sequentially emitting first and second emission signals; upon receiving said first emission signal, measuring a first intensity value being indicative of optical intensity of said first emission signal within at least a detection band; upon receiving said second emission signal, measuring a second intensity value being indicative of optical intensity of said second emission signal within said detection band; and performing said Raman spectroscopy measurement by comparing said first intensity value to said second intensity value.
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公开(公告)号：US20200284657A1
公开(公告)日：2020-09-10
申请号：US16647867
申请日：2018-09-14
摘要： A system and method for imaging a sample using Raman spectrometry. Optical fibers having opposite first ends and second ends are arranged with the first ends and second ends in respective two-dimensional arrays. The two-dimensional arrays maintain relative positions of the optical fibers to one another from the first ends to the second ends in a way that the first end of each optical fibers of the bundle can simultaneously collect a corresponding Raman signal portion scattered from specific spatial coordinates of the area of the sample. The so-collected Raman signal portions are propagated towards the corresponding second end, from which are outputted and detected simultaneously using an array of detectors.
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4.发明授权公开(公告)号：US11796475B2
公开(公告)日：2023-10-24
申请号：US17286304
申请日：2019-10-15
CPC分类号： G01N21/65 , A61B5/0075
摘要： There is described a method for performing a Raman spectroscopy measurement on a sample. The method generally has sequentially illuminating an area of said sample with first and second excitation signals, said first excitation signal being slightly spectrally spaced-apart from said second excitation signal, resulting in said area sequentially emitting first and second emission signals; upon receiving said first emission signal, measuring a first intensity value being indicative of optical intensity of said first emission signal within at least a detection band; upon receiving said second emission signal, measuring a second intensity value being indicative of optical intensity of said second emission signal within said detection band; and performing said Raman spectroscopy measurement by comparing said first intensity value to said second intensity value.
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5.发明申请公开(公告)号：US20210381983A1
公开(公告)日：2021-12-09
申请号：US17286304
申请日：2019-10-15
IPC分类号： G01N21/65
摘要： There is described a method for performing a Raman spectroscopy measurement on a sample. The method generally has sequentially illuminating an area of said sample with first and second excitation signals, said first excitation signal being slightly spectrally spaced-apart from said second excitation signal, resulting in said area sequentially emitting first and second emission signals; upon receiving said first emission signal, measuring a first intensity value being indicative of optical intensity of said first emission signal within at least a detection band; upon receiving said second emission signal, measuring a second intensity value being indicative of optical intensity of said second emission signal within said detection band; and performing said Raman spectroscopy measurement by comparing said first intensity value to said second intensity value.
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公开(公告)号：US11105682B2
公开(公告)日：2021-08-31
申请号：US16647867
申请日：2018-09-14
摘要： A system and method for imaging a sample using Raman spectrometry. Optical fibers having opposite first ends and second ends are arranged with the first ends and second ends in respective two-dimensional arrays. The two-dimensional arrays maintain relative positions of the optical fibers to one another from the first ends to the second ends in a way that the first end of each optical fibers of the bundle can simultaneously collect a corresponding Raman signal portion scattered from specific spatial coordinates of the area of the sample. The so-collected Raman signal portions are propagated towards the corresponding second end, from which are outputted and detected simultaneously using an array of detectors.
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