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公开(公告)号:US06995285B2
公开(公告)日:2006-02-07
申请号:US10161923
申请日:2002-06-04
IPC分类号: C07C233/06 , A61K31/165
CPC分类号: C07C335/16 , A61K31/145 , A61K31/16 , C07C237/04 , C07C237/22 , C07C275/26 , C07C311/20 , C07C323/60 , C07C327/42 , C07C2601/14 , C07C2602/42 , C07C2603/74 , A61K2300/00
摘要: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
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公开(公告)号:US06713650B2
公开(公告)日:2004-03-30
申请号:US10011016
申请日:2001-12-05
申请人: Prabha N. Ibrahim , Robert Jiang , Christopher Morrison , Kevin Shenk , Jeff A. Zablocki , Richard Lawn
发明人: Prabha N. Ibrahim , Robert Jiang , Christopher Morrison , Kevin Shenk , Jeff A. Zablocki , Richard Lawn
IPC分类号: C07C23305
CPC分类号: C07D319/08 , A61K31/53 , A61K45/06 , C07C237/06 , C07C237/22 , C07C237/40 , C07C275/26 , C07C311/20 , C07C323/36 , C07C323/40 , C07C323/60 , C07C327/42 , C07C327/48 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07C2602/40 , C07C2602/42 , C07C2603/74 , C07D251/16 , C07D251/52 , C07D409/12 , A61K2300/00
摘要: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
摘要翻译: 本发明提供了提高ABCA-1基因的细胞表达,促进来自细胞的胆固醇流出并增加哺乳动物,特别是人的血浆中的HDL水平的化合物。 该化合物可用于治疗冠状动脉疾病。
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公开(公告)号:US20060287275A1
公开(公告)日:2006-12-21
申请号:US11510550
申请日:2006-08-24
申请人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofen Li , Christopher Morrison , Thao Perry , Dengming Xiao
发明人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofen Li , Christopher Morrison , Thao Perry , Dengming Xiao
IPC分类号: A61K31/7076 , C07H19/16
CPC分类号: C07H19/16 , A61K31/7076
摘要: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia.
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公开(公告)号:US20090325896A1
公开(公告)日:2009-12-31
申请号:US12508385
申请日:2009-07-23
申请人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofein Li , Christopher Morrison , Thao Perry , Dengming Xiao
发明人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofein Li , Christopher Morrison , Thao Perry , Dengming Xiao
IPC分类号: A61K31/7076 , C07H19/167 , A61P9/10 , A61P9/04 , A61P3/10 , A61P3/04 , A61P3/06
CPC分类号: C07H19/16 , A61K31/7076
摘要: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia.
摘要翻译: 公开的是部分和全部A1腺苷受体激动剂的新化合物,其可用于治疗各种疾病状态,特别是心动过速和心房扑动,心绞痛,心肌梗塞和高脂血症。
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公开(公告)号:US06900219B2
公开(公告)日:2005-05-31
申请号:US10407875
申请日:2003-04-04
申请人: Prabha Ibrahim , Michael Campbell , Robert Jiang , Christopher Morrison , Kevin Shenk , William Shirley , Jeff Zablocki , Dmitry Koltun , Reina Natero
发明人: Prabha Ibrahim , Michael Campbell , Robert Jiang , Christopher Morrison , Kevin Shenk , William Shirley , Jeff Zablocki , Dmitry Koltun , Reina Natero
IPC分类号: A61K31/427 , A61K31/428 , A61K31/517 , A61P9/10 , A61K31/415 , A61K31/425
CPC分类号: A61K31/517 , A61K31/427 , A61K31/428
摘要: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
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公开(公告)号:US20050267215A1
公开(公告)日:2005-12-01
申请号:US10161923
申请日:2002-06-04
IPC分类号: A61K31/138 , A61K31/145 , A61K31/16 , A61K31/198 , A61P9/10 , C07C237/04 , C07C237/22 , C07C275/26 , C07C311/20 , C07C323/60 , C07C327/42 , C07C335/16
CPC分类号: C07C335/16 , A61K31/145 , A61K31/16 , C07C237/04 , C07C237/22 , C07C275/26 , C07C311/20 , C07C323/60 , C07C327/42 , C07C2601/14 , C07C2602/42 , C07C2603/74 , A61K2300/00
摘要: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
摘要翻译: 本发明提供了提高ABCA-1基因的细胞表达,促进来自细胞的胆固醇流出并增加哺乳动物,特别是人的血浆中的HDL水平的化合物。 该化合物可用于治疗冠状动脉疾病。
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公开(公告)号:US07696181B2
公开(公告)日:2010-04-13
申请号:US11510550
申请日:2006-08-24
申请人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofen Li , Christopher Morrison , Thao Perry , Dengming Xiao
发明人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofen Li , Christopher Morrison , Thao Perry , Dengming Xiao
IPC分类号: A61K31/70 , C07H19/167
CPC分类号: C07H19/16 , A61K31/7076
摘要: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia. The structure of the compounds is given by Formula (I): wherein R1, R2, R3, R4, R5, X, Y, Z, and T are as described herein.
摘要翻译: 公开的是部分和全部A1腺苷受体激动剂的新化合物,其可用于治疗各种疾病状态,特别是心动过速和心房扑动,心绞痛,心肌梗塞和高脂血症。 化合物的结构由式(I)给出:其中R 1,R 2,R 3,R 4,R 5,X,Y,Z和T如本文所述。
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公开(公告)号:US07144871B2
公开(公告)日:2006-12-05
申请号:US10370679
申请日:2003-02-19
申请人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofen Li , Christopher Morrison , Thao Perry , Dengming Xiao
发明人: Prabha Ibrahim , Elfatih Elzein , Kevin Shenk , Robert Jiang , Jeff Zablocki , Xiaofen Li , Christopher Morrison , Thao Perry , Dengming Xiao
IPC分类号: A61K31/70 , C07H19/167
CPC分类号: C07H19/16 , A61K31/7076
摘要: Disclosed are novel compounds that are partial and full A1 adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia.
摘要翻译: 公开了可用于治疗各种疾病状态,特别是心动过速和心房扑动,心绞痛,心肌梗塞和高脂血症的部分和全部A 1 N 2腺苷受体激动剂的新化合物。
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公开(公告)号:US20050195082A1
公开(公告)日:2005-09-08
申请号:US10906806
申请日:2005-03-08
申请人: Christopher Morrison
发明人: Christopher Morrison
CPC分类号: G08B13/149 , G01C9/06 , G01C9/10 , G01C2009/068 , G01C2009/107 , G01F13/006 , G08B13/2402 , H01H1/16 , H01H1/60 , H01H35/02
摘要: Described herein are a transient event detector (35) comprising electrical circuitry (50) suitable to detect a transient event, and a container (34) having a wall with at least two electrically conductive contacts (23, 44) electrically connected to the electrical circuitry (50), each of the at least two electrically conductive contacts (23, 44) being electrically isolated from each other, and a movable electrically conductive piece (36) that intermittently connects at least two of the at least two electrically conductive contacts when the electrically conductive piece (36) is in motion. An RF circuit (54) couples to a loop antenna (25) having a tuning capacitor (26) formed as conductive pads (26′, 26″) juxtaposed on opposing sides of a planar dielectric substrate (92). The tuning capacitor (26) has a hole (27) through it, and the hole has a size that is selected to cause the loop antenna (25) to exhibit a desired resonance frequency.
摘要翻译: 这里描述的是包括适于检测瞬态事件的电路(50)的瞬态事件检测器(35),以及具有至少两个导电触点(23,44)的容器(34),该导电触头电连接到电路 (50)中,所述至少两个导电触点(23,44)中的每一个彼此电隔离,以及当所述至少两个导电触头中的至少两个导电触点断续地连接时, 导电片(36)运动。 RF电路(54)耦合到具有调谐电容器(26)的环形天线(25),该调谐电容器形成为并置在平面介质衬底(92)的相对侧上的导电焊盘(26',26“)。 调谐电容器(26)具有穿过其的孔(27),并且该孔具有被选择为使环形天线(25)呈现期望的共振频率的尺寸。
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公开(公告)号:US20070188338A1
公开(公告)日:2007-08-16
申请号:US10592098
申请日:2005-03-08
申请人: Christopher Morrison
发明人: Christopher Morrison
CPC分类号: H01H35/02 , G01C9/06 , G01C9/10 , G01C2009/068 , G01C2009/107 , H01H1/16 , H01H1/60
摘要: A tilt sensor apparatus (36) includes one or more tilt sensors (42). Each tilt sensor (42) includes a conductive element (64) entrapped within an opening (46) formed through a middle planar substrate (38). The opening is surrounded by an opening wall (52) which is entirely covered by a conductor (54). A conductive star pattern (100′) is formed on a top planar substrate (40), and a conductive star pattern (100″) is formed on a bottom planar substrate (44). The star patterns (100) are positioned at opposing ends of the opening (46). The conductive element moves within the opening (46) as the apparatus (36) is tilted. An interrupt-driven control circuit (124) is configured to indicate a change in orientation only when a short is first detected across a contact pair (54/56, 54/60) that corresponds to an orientation opposite to a currently-indicated orientation.
摘要翻译: 倾斜传感器装置(36)包括一个或多个倾斜传感器(42)。 每个倾斜传感器(42)包括被夹在通过中间平面基板(38)形成的开口(46)内的导电元件(64)。 开口由开口壁(52)包围,该开口壁完全被导体(54)覆盖。 导电星形图案(100')形成在顶部平面基板(40)上,并且导电星形图案(100“)形成在底部平面基板(44)上。 星形图案(100)位于开口(46)的相对端。 当设备(36)倾斜时,导电元件在开口(46)内移动。 中断驱动控制电路(124)被配置为仅当跨越对应于与当前指示的取向相反的方向的触点对(54/56,54/60)首次检测到短路时才指示取向的变化。
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