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    Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
    10.
    发明授权
    Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method 有权
    用作抗糖尿病和抗肥胖剂的取代的杂环衍生物和方法

    公开(公告)号：US07279485B2

    公开(公告)日：2007-10-09

    申请号：US10616365

    申请日：2003-07-08

    申请人： Peter T. W. Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Z. Ding ,  Timothy F. Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

    发明人： Peter T. W. Cheng ,  Sean Chen ,  Pratik Devasthale ,  Charles Z. Ding ,  Timothy F. Herpin ,  Shung Wu ,  Hao Zhang ,  Wei Wang ,  Xiang-Yang Ye

    IPC分类号： A01N43/54 ,  A01N43/76 ,  A61K31/505 ,  C07D239/02 ,  C07D413/00

    CPC分类号： C07D413/12 ,  C07D413/14

    摘要： Substituted heterocyclic derivatives are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; D is —CH═ or C═O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4, X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C; A, B, R1, R2, R2a, R2b, R4, R3, E, Z and Y are as defined herein. In addition, a method is provided for treating diabetes, Type 2 diabetes, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids or glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, or atherosclerosis, wherein the substituted heterocyclic derivatives are administered in a therapeutically effective amount to a patient.

    摘要翻译： 提供了取代的杂环衍生物，其具有其中Z 1是（CH 2 CH 2）q或C-O的结构; Z 2是（CH 2）2或C-O; D是-CH-或C-O或（CH 2 CH 2）m，其中m是0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; X是CH或N; X 2是C，N，O或S; X 3是C，N，O或S; X 4是C，N，O或S; X 5是C，N，O或S; X 6是C，N，O或S; 条件是X 2，X 3，X 4，X 5和X 3中的至少一个， 6是N; 和X 2，X 3，X 4，X 5和X 6中的至少一个 是C; A，B，R 1，R 2，R 2a，R 2b，R 4， R 3，R 3，E，Z和Y如本文所定义。 另外，提供了一种治疗糖尿病，2型糖尿病，胰岛素抵抗，高血糖症，高胰岛素血症，升高的脂肪酸或甘油血糖水平，高脂血症，肥胖症，高甘油三酯血症，综合征X或动脉粥样硬化的方法，其中给予取代的杂环衍生物 以治疗有效量给予患者。