Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
    2.
    发明授权
    Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method 有权
    用作抗糖尿病和抗肥胖剂的取代的杂环衍生物和方法

    公开(公告)号:US07279485B2

    公开(公告)日:2007-10-09

    申请号:US10616365

    申请日:2003-07-08

    CPC分类号: C07D413/12 C07D413/14

    摘要: Substituted heterocyclic derivatives are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; D is —CH═ or C═O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4, X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C; A, B, R1, R2, R2a, R2b, R4, R3, E, Z and Y are as defined herein. In addition, a method is provided for treating diabetes, Type 2 diabetes, insulin resistance, hyperglycemia, hyperinsulinemia, elevated blood levels of fatty acids or glycerol, hyperlipidemia, obesity, hypertriglyceridemia, Syndrome X, or atherosclerosis, wherein the substituted heterocyclic derivatives are administered in a therapeutically effective amount to a patient.

    摘要翻译: 提供了取代的杂环衍生物,其具有其中Z 1是(CH 2 CH 2)q或C-O的结构; Z 2是(CH 2)2或C-O; D是-CH-或C-O或(CH 2 CH 2)m,其中m是0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; X是CH或N; X 2是C,N,O或S; X 3是C,N,O或S; X 4是C,N,O或S; X 5是C,N,O或S; X 6是C,N,O或S; 条件是X 2,X 3,X 4,X 5和X 3中的至少一个, 6是N; 和X 2,X 3,X 4,X 5和X 6中的至少一个 是C; A,B,R 1,R 2,R 2a,R 2b,R 4, R 3,R 3,E,Z和Y如本文所定义。 另外,提供了一种治疗糖尿病,2型糖尿病,胰岛素抵抗,高血糖症,高胰岛素血症,升高的脂肪酸或甘油血糖水平,高脂血症,肥胖症,高甘油三酯血症,综合征X或动脉粥样硬化的方法,其中给予取代的杂环衍生物 以治疗有效量给予患者。

    RISK RELATIONSHIP MENTAL HEALTH EQUIPMENT MANAGEMENT SYSTEM

    公开(公告)号:US20240312634A1

    公开(公告)日:2024-09-19

    申请号:US18183493

    申请日:2023-03-14

    IPC分类号: G16H50/30 G16H10/60

    CPC分类号: G16H50/30 G16H10/60

    摘要: A mental health equipment data store may contain electronic records associated with mental health equipment identifiers. For each mental health equipment identifier, the data store may include a communication address and associated equipment parameters. A risk relationship data store may contain electronic records associated with parties having risk relationships with an enterprise. A back-end application computer server may associate a selected equipment identifier in the mental health equipment data store with a selected party having a risk relationship with the enterprise. The server may update the risk relationship data store with the selected equipment identifier and arrange to collect selected mental health data for the selected party in accordance with the communication address of the selected equipment identifier. The selected mental health data is input to a predictive model algorithm, and the server automatically executes a treatment workflow for the selected party based on an output of the algorithm.

    Fishing rod holder
    10.
    外观设计

    公开(公告)号:USD1040963S1

    公开(公告)日:2024-09-03

    申请号:US29851189

    申请日:2022-08-26

    申请人: Wei Wang

    设计人: Wei Wang

    摘要: FIG. 1 is a first perspective view of a fishing rod holder showing my new design;
    FIG. 2 is a second perspective view thereof;
    FIG. 3 is a front view thereof;
    FIG. 4 is a back view thereof;
    FIG. 5 is a left side view thereof;
    FIG. 6 is a right side view thereof;
    FIG. 7 is a top view thereof; and,
    FIG. 8 is a bottom view thereof.
    The broken lines shown in the drawings depict portions of the fishing rod holder that form no part of the claimed design.