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公开(公告)号：US09719982B2
公开(公告)日：2017-08-01
申请号：US14642906
申请日：2015-03-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Adam W. Feinberg , Patrick W. Alford , Anna Grosberg , Mark Daniel Brigham , Josue A. Goss
CPC classification number: G01N33/5061 , C12Q1/025 , C40B30/06 , G01N33/5032 , G01N33/5088 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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2.发明申请ENGINEERED CELL GROWTH ON POLYMERIC FILMS AND BIOTECHNOLOGICAL APPLICATION THEREOF 有权聚合物膜上的工程细胞生长及其生物应用公开(公告)号：US20140004553A1
公开(公告)日：2014-01-02
申请号：US13922432
申请日：2013-06-20
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Adam W. Feinberg , George M. Whitesides , Sergey S. Shevkoplyas , Alexander Feigel
IPC: G01N33/50
CPC classification number: G01N33/5061 , C12N5/0062 , C12N5/0657 , C12N2533/30 , C12N2533/52 , C12N2539/10 , G01N2500/10
Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
Abstract translation: 独立的薄膜由包括涂覆有牺牲聚合物层的基层的结构制成，牺牲聚合物层又被柔性聚合物层涂覆。 然后将细胞接种到柔性聚合物层上并进行培养以形成组织。 然后将柔性聚合物层从基底层释放出来，以产生包含柔性聚合物层上的组织的自立薄膜。 在一个实施方案中，细胞是肌细胞，其可被致动以推动或置换自立膜。 在另一个实施方案中，自立膜用于治疗受损的人体组织。
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公开(公告)号：US10753925B2
公开(公告)日：2020-08-25
申请号：US15662371
申请日：2017-07-28
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Adam W. Feinberg , Patrick W. Alford , Anna Grosberg , Mark Daniel Brigham , Josue A. Goss
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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4.发明申请HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION AND DEVICES FOR USE THEREIN 有权用于确定合同功能的高通量测量及其使用的装置公开(公告)号：US20160003806A1
公开(公告)日：2016-01-07
申请号：US14642906
申请日：2015-03-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Adam W. Feinberg , Patrick W. Alford , Anna Grosberg , Mark Daniel Brigham , Josue A. Goss
IPC: G01N33/50
CPC classification number: G01N33/5061 , C12Q1/025 , C40B30/06 , G01N33/5032 , G01N33/5088 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
Abstract translation: 本发明提供用于鉴定调节收缩功能的化合物的高通量测定，以及适用于这些测定的装置。
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公开(公告)号：US10725021B2
公开(公告)日：2020-07-28
申请号：US15693565
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue A. Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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Patent Agency Ranking
公开(公告)号：US20180209957A1
公开(公告)日：2018-07-26
申请号：US15693565
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue A. Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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公开(公告)号：US09857356B2
公开(公告)日：2018-01-02
申请号：US14362287
申请日：2012-12-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue Adrian Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays.
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8.发明申请公开(公告)号：US20180172672A1
公开(公告)日：2018-06-21
申请号：US15662371
申请日：2017-07-28
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Adam W. Feinberg , Patrick W. Alford , Anna Grosberg , Mark Daniel Brigham , Josue A. Goss
CPC classification number: G01N33/5061 , C12Q1/025 , C40B30/06 , G01N33/5032 , G01N33/5088 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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9.发明授权Engineered cell growth on polymeric films and biotechnological application thereof 有权聚合物膜上的工程化细胞生长及其生物技术应用公开(公告)号：US09383350B2
公开(公告)日：2016-07-05
申请号：US13922432
申请日：2013-06-20
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Adam W. Feinberg , George M. Whitesides , Sergey S. Shevkoplyas , Alexander Feigel
CPC classification number: G01N33/5061 , C12N5/0062 , C12N5/0657 , C12N2533/30 , C12N2533/52 , C12N2539/10 , G01N2500/10
Abstract: A free-standing thin film is fabricated from a structure comprising a base layer coated with a sacrificial polymer layer, which is in turn coated with a flexible polymer layer. Cells are then seeded onto the flexible polymer layer and cultured to form a tissue. The flexible polymer layer is then released from the base layer to produce a free-standing thin film comprising the tissue on the flexible polymer layer. In one embodiment, the cells are myocytes, which can be actuated to propel or displace the free-standing film. In another embodiment, the free-standing film is used to treat injured human tissue.
Abstract translation: 独立的薄膜由包括涂覆有牺牲聚合物层的基层的结构制成，牺牲聚合物层又被柔性聚合物层涂覆。 然后将细胞接种到柔性聚合物层上并进行培养以形成组织。 然后将柔性聚合物层从基底层释放出来，以产生包含柔性聚合物层上的组织的自立薄膜。 在一个实施方案中，细胞是肌细胞，其可被致动以推动或置换自立膜。 在另一个实施方案中，自立膜用于治疗受损的人体组织。
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公开(公告)号：US20140342394A1
公开(公告)日：2014-11-20
申请号：US14362287
申请日：2012-12-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue Adrian Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agrawal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays.
Abstract translation: 本发明提供用于鉴定调节收缩功能的化合物的高通量测定，以及适用于这些测定的装置。
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