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公开(公告)号：US10591458B2
公开(公告)日：2020-03-17
申请号：US15116258
申请日：2015-02-18
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Johan Ulrik Lind , Jennifer Ann Lewis , Joost Johan Vlassak , Hongyan Yuan , Travis Alexander Busbee , Ian Perkins , Christophe Chantre
IPC: G01N33/483 , A61B5/00 , A61B5/053
Abstract: Embodiments described herein are directed to devices for supporting growth of anisotropic muscle tissue layers and in vitro readout and quantification of force generated by the tissue layers using one or more strain-sensing elements integrated into the device. Embodiments also include multiplexed apparatuses of multiple independent devices, methods of fabricating the devices and apparatuses, and methods of using the devices and apparatuses.
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公开(公告)号：US20140342394A1
公开(公告)日：2014-11-20
申请号：US14362287
申请日：2012-12-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue Adrian Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agrawal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays.
Abstract translation: 本发明提供用于鉴定调节收缩功能的化合物的高通量测定，以及适用于这些测定的装置。
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公开(公告)号：US10997871B2
公开(公告)日：2021-05-04
申请号：US15514011
申请日：2015-09-24
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Sung-Jin Park , Patrick Healy Campbell , Johan Ulrik Lind
Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).
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公开(公告)号：US20180357927A1
公开(公告)日：2018-12-13
申请号：US15514011
申请日：2015-09-24
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Sung-Jin Park , Patrick Healy Campbell , Johan Ulrik Lind
CPC classification number: G09B23/28 , C12M21/08 , C12M25/02 , C12M31/10 , C12M41/46 , C12N5/0657 , G01N3/32 , G01N33/5091 , G01N2203/0089
Abstract: Exemplary embodiments provide systems, devices and methods for simultaneously measuring mechanical and electrophysiological tissue responses (e.g., contractile function, or the like).
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Patent Agency Ranking
5.发明申请ANISOTROPIC MUSCULAR TISSUE DEVICES WITH INTEGRATED ELECTRICAL FORCE READOUTS 审中-公开具有集成电力准备工具的各向异性肌肉组织装置公开(公告)号：US20170016875A1
公开(公告)日：2017-01-19
申请号：US15116258
申请日：2015-02-18
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Johan Ulrik Lind , Jennifer Ann Lewis , Joost Johan Vlassak , Hongyan Yuan , Travis Alexander Busbee , Ian Perkins , Christophe Chantre
IPC: G01N33/483
CPC classification number: G01N33/4833 , A61B5/053 , A61B5/4519
Abstract: Embodiments described herein are directed to devices for supporting growth of anisotropic muscle tissue layers and in vitro readout and quantification of force generated by the tissue layers using one or more strain-sensing elements integrated into the device. Embodiments also include multiplexed apparatuses of multiple independent devices, methods of fabricating the devices and apparatuses, and methods of using the devices and apparatuses.
Abstract translation: 本文描述的实施例涉及用于支持各向异性肌肉组织层的生长的装置，以及使用集成到装置中的一个或多个应变感测元件由组织层产生的力的体外读出和定量。 实施例还包括多个独立设备的复用设备，制造设备和设备的方法以及使用设备和设备的方法。
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公开(公告)号：US10725021B2
公开(公告)日：2020-07-28
申请号：US15693565
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue A. Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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公开(公告)号：US20180209957A1
公开(公告)日：2018-07-26
申请号：US15693565
申请日：2017-09-01
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue A. Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
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公开(公告)号：US09857356B2
公开(公告)日：2018-01-02
申请号：US14362287
申请日：2012-12-10
Applicant: President and Fellows of Harvard College
Inventor： Kevin Kit Parker , Josue Adrian Goss , Anna Grosberg , Patrick W. Alford , Adam W. Feinberg , Ashutosh Agarwal , Megan Laura McCain , Johan Ulrik Lind
IPC: G01N33/50
CPC classification number: G01N33/5008 , G01N33/5088 , G01N2500/04 , G01N2500/10
Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays.
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公开(公告)号：US20160000886A1
公开(公告)日：2016-01-07
申请号：US14768846
申请日：2014-02-21
Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor： Kevin Kit Parker , Johan Ulrik Lind , David A. Weitz , Nichlaus J. Carroll , Alireza Abbaspourrad
CPC classification number: A61K38/465 , A61K9/0019 , A61K9/113 , A61K9/1273 , A61K47/34 , A61K47/42 , C12Y301/01008
Abstract: The present invention provides nano structured active therapeutic vehicles which include a biodegradable polymeric fiber and/or thread comprising a porous particle which encapsulates an active agent. The vehicles of the present invention may be used to provide sustained release of the active agent to a subject.
Abstract translation: 本发明提供纳米结构的活性治疗载体，其包括可生物降解的聚合物纤维和/或线，其包含封装活性剂的多孔颗粒。 本发明的载体可用于向受试者提供活性剂的持续释放。
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