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公开(公告)号：US11286491B2
公开(公告)日：2022-03-29
申请号：US16785874
申请日：2020-02-10
Applicant: President and Fellows of Harvard College
Inventor： Neel Satish Joshi , Peter Q. Nguyen , Anna M. Duraj-Thatte , Pichet Praveschotinunt
Abstract: Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
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公开(公告)号：US20200248190A1
公开(公告)日：2020-08-06
申请号：US16785874
申请日：2020-02-10
Applicant: President and Fellows of Harvard College
Inventor： Neel Satish Joshi , Peter Q. Nguyen , Anna M. Duraj-Thatte , Pichet Praveschotinunt
Abstract: Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
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公开(公告)号：US20180258435A1
公开(公告)日：2018-09-13
申请号：US15564619
申请日：2016-04-06
Applicant: President and Fellows of Harvard College
Inventor： Neel S. Joshi , Peter Q. Nguyen , Anna Duraj-Thatte , Pichet Praveschotinunt
IPC: C12N15/62 , C12N15/70 , C07K14/245 , A61P1/00 , C07K14/33
CPC classification number: C12N15/62 , A61K35/74 , A61P1/00 , C07K14/245 , C07K14/33 , C07K2317/24 , C07K2319/00 , C12N15/70 , C12N2800/101
Abstract: Embodiments of the present disclosure are directed to methods of genetically modifying bacteria to create amyloid-based materials, such as biofilms created by amyloid fibers, having nonnative functional polypeptides expressed thereon and connected thereto by a linker domain optimized for functioning of the non-native functional polypeptides. According to one aspect, the linker domain is optimized for functioning of a CsgA protein as is it assembled into an amyloid state and for functioning of the functional polypeptide. Exemplary biofilms may include living bacterial cells, non-living bacterial cells or combinations of living bacterial cells and non-living bacterial cells. Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
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