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公开(公告)号：US20210163558A1
公开(公告)日：2021-06-03
申请号：US17254019
申请日：2019-06-21
IPC分类号： C07K14/47 , C07K14/78 , C07K14/75 , A61L24/00 , A61L24/10 , A61L15/42 , A61L15/32 , A61L27/52 , A61L27/22 , C09D11/04 , B33Y70/00
摘要： Disclosed herein are engineered bacteria that manufacture biofilms from bacterial amyloid structures. These biofilms and biofilm matrices are capable of generating fibrous proteinaceous networks and being used as 3D-printing inks.
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公开(公告)号：US11859173B2
公开(公告)日：2024-01-02
申请号：US17366757
申请日：2021-07-02
CPC分类号： C12N1/20 , C12N1/18 , C12R2001/19
摘要： Disclosed are biomaterials, including engineered living materials (ELMs), comprising a plurality of microbial cells, wherein the material has a Young's Modulus of at least 5 Gpa; and methods of fabricating said biomaterials.
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公开(公告)号：US20220025319A1
公开(公告)日：2022-01-27
申请号：US17366757
申请日：2021-07-02
申请人： Northeastern University Center for Research Innovation, Northeastern Univ. , President and Fellows of Harvard College
摘要： Disclosed are biomaterials, including engineered living materials (ELMs), comprising a plurality of microbial cells, wherein the material has a Young's Modulus of at least 5 Gpa; and methods of fabricating said biomaterials.
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公开(公告)号：US12060398B2
公开(公告)日：2024-08-13
申请号：US17254019
申请日：2019-06-21
IPC分类号： C07K14/47 , A61L15/32 , A61L15/42 , A61L24/00 , A61L24/10 , A61L27/22 , A61L27/52 , B33Y70/00 , C07K14/75 , C07K14/78 , C09D11/04
CPC分类号： C07K14/4711 , A61L15/32 , A61L15/42 , A61L24/0031 , A61L24/108 , A61L27/227 , A61L27/52 , B33Y70/00 , C07K14/75 , C07K14/78 , C09D11/04 , C07K2319/00
摘要： Disclosed herein are engineered bacteria that manufacture biofilms from bacterial amyloid structures. These biofilms and biofilm matrices are capable of generating fibrous proteinaceous networks and being used as 3D-printing inks.
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公开(公告)号：US20180258435A1
公开(公告)日：2018-09-13
申请号：US15564619
申请日：2016-04-06
IPC分类号： C12N15/62 , C12N15/70 , C07K14/245 , A61P1/00 , C07K14/33
CPC分类号： C12N15/62 , A61K35/74 , A61P1/00 , C07K14/245 , C07K14/33 , C07K2317/24 , C07K2319/00 , C12N15/70 , C12N2800/101
摘要： Embodiments of the present disclosure are directed to methods of genetically modifying bacteria to create amyloid-based materials, such as biofilms created by amyloid fibers, having nonnative functional polypeptides expressed thereon and connected thereto by a linker domain optimized for functioning of the non-native functional polypeptides. According to one aspect, the linker domain is optimized for functioning of a CsgA protein as is it assembled into an amyloid state and for functioning of the functional polypeptide. Exemplary biofilms may include living bacterial cells, non-living bacterial cells or combinations of living bacterial cells and non-living bacterial cells. Methods of making biofilms having non-native functional polypeptides attached thereto are provided.
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