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公开(公告)号：US10548878B2
公开(公告)日：2020-02-04
申请号：US15747290
申请日：2016-07-25
发明人： Benito Munoz , Cecilia M. Bastos , John Miller
IPC分类号： A61K31/42 , A61K31/341 , A61K31/422 , A61K31/433 , A61K31/454 , A61K31/47 , A61K45/06 , A61P11/12 , A61K31/4178 , A61K31/4245 , A61K31/5377
摘要： The present disclosure features compounds such as those having the Formulae (I) and (II), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (I) or (II).
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公开(公告)号：US20190154661A1
公开(公告)日：2019-05-23
申请号：US16300219
申请日：2017-05-09
发明人： John Miller , Lawrence J. Drew, II , Po-Shun Lee
摘要： The present disclosure is directed to methods of identifying CFTR modulators using non-mutant or mutant CFTR expressing cells in the presence of a CFTR amplifier compound.
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公开(公告)号：US20220175735A1
公开(公告)日：2022-06-09
申请号：US17354751
申请日：2021-06-22
发明人： John Miller , Cecilia M. Bastos , Benito Munoz
IPC分类号： A61K31/422 , A61K31/404 , A61K31/4245 , A61K31/47 , A61K31/7036 , A61K45/06 , A61K31/443 , A61P11/06 , A61P11/08 , A61K9/00 , A61K31/341 , A61K31/4192 , A61K31/433 , A61K31/454 , A61K31/5377
摘要： The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.
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公开(公告)号：US11083709B2
公开(公告)日：2021-08-10
申请号：US16710688
申请日：2019-12-11
发明人： Benito Munoz , Cecilia M. Bastos , John Miller
IPC分类号： A61K31/42 , A61P11/12 , A61K31/341 , A61K31/422 , A61K31/433 , A61K31/454 , A61K31/47 , A61K31/5377 , C07D261/14 , C07D413/14 , C07D407/12 , C07D417/12 , C07D409/14 , C07D405/12 , C07D413/12 , C07D307/54 , A61K31/4178 , A61K31/4245 , A61K45/06
摘要： The present disclosure features compounds such as those having the Formulae (I) and (II), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (I) or (II).
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公开(公告)号：US20180214419A1
公开(公告)日：2018-08-02
申请号：US15747290
申请日：2016-07-25
发明人： Benito Munoz , Cecilia M. Bastos , John Miller
IPC分类号： A61K31/42 , A61K31/422 , A61K31/5377 , A61K31/4245 , A61K31/341 , A61K31/4178 , A61K31/454 , A61K31/433 , A61K31/47 , A61K45/06 , A61P11/12
摘要： The present disclosure features compounds such as those having the Formulae (I) and (II), which can increase cystic fibrosis transmembrane conductance regulator (CFTR) activity as measured in human bronchial epithelial (hBE) cells. The present disclosure also features methods of treating a condition associated with decreased CFTR activity or a condition associated with a dysfunction of proteostasis comprising administering to a subject an effective amount of a disclosed compound, such as a compound of Formula (I) or (II).
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公开(公告)号：US20180369209A1
公开(公告)日：2018-12-27
申请号：US16065384
申请日：2016-12-22
发明人： John Miller , Cecilia M. Bastos , Benito Munoz
IPC分类号： A61K31/422 , A61K31/4245 , A61K31/454 , A61K31/4192 , A61K31/433 , A61K31/341 , A61K31/5377 , A61K9/00 , A61P11/06 , A61P11/08
摘要： The present disclosure features disclosed method of treating disorders such as COPD, bronchitis and/or asthma using disclosed compounds, optionally together with one or more additional active agents. Contemplated methods include administrating orally or by inhalation to a patient one or more disclosed compounds.
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