公开(公告)号：US20230211161A1

公开(公告)日：2023-07-06

申请号：US17566674

申请日：2021-12-30

申请人： Pulse Biosciences, Inc.

发明人： Cameron D. HINMAN ,  Wesley C. JOE

IPC分类号： A61N1/36 ,  A61N1/04

CPC分类号： A61N1/36034 ,  A61N1/0496

摘要： Applicators, systems, and methods for delivering electrical energy to a target treatment region with large area surface electrodes are disclosed. In one example, a system may include a housing, a pulse generator, and a treatment applicator coupled to the pulse generator and configured to deliver sub-microsecond high-voltage electric pulses from the pulse generator. The treatment applicator may include a first and second electrodes coupled to a substrate, where the first and second electrodes are configured to provide a uniform gap between edges of the first and second electrodes.

公开(公告)号：US20200297998A1

公开(公告)日：2020-09-24

申请号：US16765661

申请日：2018-08-06

申请人： PULSE BIOSCIENCES, INC.

发明人： David J. DANITZ ,  Cameron D. HINMAN ,  Edward EBBERS ,  Richard L. NUCCITELLI ,  Kevin L. MOSS ,  Darrin R. UECKER

IPC分类号： A61N1/32 ,  A61N1/05 ,  A61N1/36 ,  A61N1/02

摘要： Methods and apparatuses for treating a tissue with an electric treatment by rotating a pattern of electrodes partway through a treatment is disclosed. Also described herein are methods and apparatuses to treat tissue, including treating skin disorders, by selectively de-nucleating epidermal cells without provoking a significant inflammatory response, e.g., without increasing the density of leukocytes in the treated skin, and without affecting the non-cellular components of the dermis.

公开(公告)号：US20240342465A1

公开(公告)日：2024-10-17

申请号：US18682890

申请日：2022-08-08

申请人： Pulse Biosciences, Inc.

发明人： Kevin L. MOSS ,  David J. DANITZ ,  Richard J. CONNOLLY ,  Katherine P. WEILBACHER ,  Cameron D. HINMAN

IPC分类号： A61N1/04 ,  A61N1/05 ,  A61N1/32

CPC分类号： A61N1/0476 ,  A61N1/0502 ,  A61N1/328

摘要： Treatment applicators and methods including treatment applicators for delivering electrical energy to a target tissue that are configured to reduce or eliminate arcing as well as provide enhance targeting to tissue surfaces or regions just below the surface of the tissue.

公开(公告)号：US20230218335A1

公开(公告)日：2023-07-13

申请号：US18000013

申请日：2021-06-01

申请人： PULSE BIOSCIENCES, INC.

发明人： Cameron D. HINMAN ,  Kevin L. MOSS ,  David J. DANITZ

IPC分类号： A61B18/14 ,  A61B18/12

CPC分类号： A61B18/1442 ,  A61B18/1492 ,  A61B18/1206 ,  A61B18/1482 ,  A61B2018/145

摘要： Described herein are elongate applicator tools adapted to be inserted into a body to deliver high voltage, sub-microsecond electrical energy to target tissue. These tools may be configured as laparoscopes, endoscopes, and/or catheters. Also disclosed herein systems including these tools and method of their operation.

公开(公告)号：US20190217080A1

公开(公告)日：2019-07-18

申请号：US16247469

申请日：2019-01-14

申请人： Pulse Biosciences, Inc.

发明人： Kevin L. MOSS ,  Christopher J. FOSTER ,  Cameron D. HINMAN ,  David J. DANITZ ,  Darrin R. UECKER

IPC分类号： A61N1/05

CPC分类号： A61B34/37 ,  A61B18/1445 ,  A61B34/32 ,  A61B2018/1425 ,  A61B2018/1432 ,  A61N1/0502 ,  A61N1/40

摘要： Described herein are treatment tip apparatuses (e.g., devices, systems, etc.) including one, or more preferably a plurality, of electrodes that are protected by an electrode partition, such as an electrode housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment. In particular, these apparatuses may include a plurality of treatment electrodes (e.g., needle electrodes) and be configured for the delivery of nanosecond pulsed electric fields.

公开(公告)号：US20230414274A1

公开(公告)日：2023-12-28

申请号：US18252812

申请日：2021-11-12

申请人： PULSE BIOSCIENCES, INC.

发明人： Kevin L. MOSS ,  Richard J. CONNOLLY ,  David J. DANITZ ,  Mitchell E. LEVINSON ,  Darrin R. UECKER ,  Cameron D. HINMAN

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/0016

摘要： Described herein are elongate applicator tools adapted to be inserted into an anatomical structure of a body to deliver electric treatment, for example, high voltage, sub-microsecond electrical energy, to a target tissue. These applicator tools may be configured for insertion into a blood vessel, an otolaryngological structure (such as an ear, nose, or throat, including anatomical structures, such as a turbinate, tonsils, tongue, soft palate, parotid glands, esophageal glands), a gastrointestinal tract (e.g., stomach, small intestine, large intestine, duodenum, colon, etc., including the esophagus), structures of the female reproductive system (e.g., fallopian tubes, uterus), and/or a respiratory tract (e.g., trachea, pharynx, larynx, and bronchi). Also disclosed herein are systems including these tools and methods of their operation.

公开(公告)号：US20220008122A1

公开(公告)日：2022-01-13

申请号：US17284029

申请日：2019-10-09

申请人： PULSE BIOSCIENCES, INC.

发明人： Lauren M. JAUREGUI JOHNSTON ,  Edward A. EBBERS ,  David J. DANITZ ,  Richard L. NUCCITELLI ,  Darrin R. UECKER ,  Kevin L. MOSS ,  Cameron D. HINMAN

IPC分类号： A61B18/14 ,  A61B34/30

摘要： Described herein are methods and apparatuses for reducing or eliminating skin glands (e g , sebaceous, eccrine and apocrine) with an electric treatment. Also described herein are methods for treating and/or preventing a disorder of a skin gland. For example, described herein are methods of treating sebaceous hyperplasia.

公开(公告)号：US20190046791A1

公开(公告)日：2019-02-14

申请号：US15973254

申请日：2018-05-07

申请人： Pulse Biosciences, Inc.

发明人： Edward EBBERS ,  David J. DANITZ ,  Richard L. NUCCITELLI ,  Darrin R. UECKER ,  Cameron D. HINMAN ,  Kevin L. MOSS

IPC分类号： A61N1/32 ,  A61N1/04

摘要： Methods and apparatuses for treating a tissue with an electric treatment by rotating a pattern of electrodes partway through a treatment is disclosed. Also described herein are methods and apparatuses to treat tissue, including treating skin disorders, by selectively de-nucleating epidermal cells without provoking a significant inflammatory response, e.g., without increasing the density of leukocytes in the treated skin, and without affecting the non-cellular components of the dermis.

公开(公告)号：US20230404646A1

公开(公告)日：2023-12-21

申请号：US18460488

申请日：2023-09-01

申请人： Pulse Biosciences, Inc.

发明人： Cameron D. HINMAN ,  Kevin L. MOSS ,  Wesley C. JOE ,  Peter H. ROBINO

IPC分类号： A61B18/12

CPC分类号： A61B18/1233 ,  A61B2018/00178

摘要： Methods and apparatuses (e.g., devices, instruments and systems, including applicator handles for use with pulse generators) for automatically and/or mechanically setting impedance matching for connecting the applicator handle with different electrode tips. These methods and apparatuses may be useful for applying therapeutic energy, including but not limited to short, high field strength electric pulses, while avoiding the risk of arcing or otherwise harming the tissue.

公开(公告)号：US20220151679A1

公开(公告)日：2022-05-19

申请号：US17590790

申请日：2022-02-01

申请人： Pulse Biosciences, Inc.

发明人： Cameron D. HINMAN ,  Kevin L. MOSS ,  Wesley C. JOE ,  Peter H. ROBINO

IPC分类号： A61B18/12

摘要： Methods and apparatuses (e.g., devices, instruments and systems, including applicator handles for use with pulse generators) for automatically and/or mechanically setting impedance matching for connecting the applicator handle with different electrode tips. These methods and apparatuses may be useful for applying therapeutic energy, including but not limited to short, high field strength electric pulses, while avoiding the risk of arcing or otherwise harming the tissue.