公开(公告)号：US10000581B2

公开(公告)日：2018-06-19

申请号：US14889722

申请日：2014-05-07

申请人： Purdue Research Foundation

发明人： David H. Thompson ,  Aditya Kulkarni ,  Christopher Collins ,  Yawo Mondjinou

IPC分类号： A61K8/00 ,  C08B37/16 ,  G01N33/68 ,  A61K31/724 ,  A61K31/765 ,  A61K47/48 ,  A61K51/06 ,  A61K51/12 ,  C08G83/00 ,  A61K47/54

CPC分类号： C08B37/0015 ,  A61K31/724 ,  A61K31/765 ,  A61K47/547 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6951 ,  A61K51/065 ,  A61K51/1268 ,  C08G83/007 ,  G01N33/6893

摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.

公开(公告)号：US11434330B2

公开(公告)日：2022-09-06

申请号：US15768365

申请日：2016-10-14

申请人： Purdue Research Foundation

发明人： David H. Thompson ,  Seok-Hee Hyun ,  Yawo Mondjinou ,  Christopher Collins

IPC分类号： C08G83/00 ,  A61K31/724 ,  A61K51/06 ,  C08K5/053 ,  C08K5/17 ,  C08L5/16 ,  A61P43/00

摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.

公开(公告)号：US20160083485A1

公开(公告)日：2016-03-24

申请号：US14889722

申请日：2014-05-07

申请人： PURDUE RESEARCH FOUNDATION

发明人： David H. Thompson ,  Aditya Kulkarni ,  Christopher Collins ,  Yawo Mondjinou

IPC分类号： C08B37/16 ,  A61K47/48 ,  A61K51/12 ,  A61K51/06 ,  A61K31/765 ,  A61K31/724

CPC分类号： C08B37/0015 ,  A61K31/724 ,  A61K31/765 ,  A61K47/547 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6951 ,  A61K51/065 ,  A61K51/1268 ,  C08G83/007 ,  G01N33/6893

摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.

摘要翻译： 本发明的各种实施方案涉及包含泊洛沙姆核心和至少一种环糊精的聚轮烷和使用本发明的各种实施方案使用聚轮烷成像（例如，MRI）的尼曼 - 皮克C型（NPC）的方法。

公开(公告)号：US20210040270A1

公开(公告)日：2021-02-11

申请号：US15768365

申请日：2016-10-14

申请人： Purdue Research Foundation

发明人： David H. Thompson ,  Seok-Hee Hyun ,  Yawo Mondjinou ,  Christopher Collins

IPC分类号： C08G83/00 ,  C08L5/16 ,  C08K5/17 ,  C08K5/053 ,  A61K51/06 ,  A61K31/724

摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.

公开(公告)号：US10689462B2

公开(公告)日：2020-06-23

申请号：US15978872

申请日：2018-05-14

申请人： Purdue Research Foundation

发明人： David H. Thompson ,  Aditya Kulkarni ,  Christopher Collins ,  Yawo Mondjinou

IPC分类号： A61K8/00 ,  C08B37/16 ,  G01N33/68 ,  A61K47/60 ,  A61K31/724 ,  A61K31/765 ,  A61K51/06 ,  A61K51/12 ,  A61K47/61 ,  A61K47/69 ,  C08G83/00 ,  A61K47/54

摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.

公开(公告)号：US20180258192A1

公开(公告)日：2018-09-13

申请号：US15978872

申请日：2018-05-14

申请人： Purdue Research Foundation

发明人： David H. Thompson ,  Aditya Kulkarni ,  Christopher Collins ,  Yawo Mondjinou

IPC分类号： C08B37/16 ,  A61K51/12 ,  A61K51/06 ,  G01N33/68

摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.