公开(公告)号：US12116461B2

公开(公告)日：2024-10-15

申请号：US17409450

申请日：2021-08-23

Applicant: Northwestern University

Inventor： Samuel I. Stupp ,  Alexandra N. Kolberg ,  Tristan D. Clemons ,  Stacey M. Chin

IPC: C08L101/00 ,  B33Y80/00 ,  C08G83/00 ,  C08J3/075 ,  C09D5/02 ,  C12N5/00 ,  C12N5/0793 ,  C08L5/16 ,  C08L101/14

CPC classification number: C08G83/008 ,  B33Y80/00 ,  C08J3/075 ,  C08L101/00 ,  C09D5/02 ,  C12N5/00 ,  C12N5/0619 ,  C08G2210/00 ,  C08J2300/204 ,  C08L5/16 ,  C08L101/14 ,  C12N2501/13 ,  C12N2513/00 ,  C12N2533/40 ,  C12N2533/70

Abstract: The disclosure relates to compositions and superstructures comprising peptide amphiphiles. In some aspects, the disclosure relates to compositions and superstructures comprising host and guest peptide amphiphiles, wherein the host and guest moieties of the peptide amphiphiles interact via non-covalent interactions to form a supramolecular assembly, such a superstructure. In some aspects, the superstructure further comprises a bioactive moiety. Suitable bioactive moieties may be selected to promote cell growth, migration, and/or differentiation.

公开(公告)号：US20240287212A1

公开(公告)日：2024-08-29

申请号：US18042703

申请日：2022-09-29

Applicant: YANGZHOU UNIVERSITY

Inventor： Wang ZHANG ,  Yuping WANG ,  Junqiang GUO ,  Guowang DIAO

IPC: C08B37/16 ,  C08J3/24 ,  C08L5/16

CPC classification number: C08B37/0015 ,  C08J3/24 ,  C08L5/16 ,  C08J2405/16

Abstract: The present disclosure provides a water-soluble 1,3-diphenylguanidine (DPG)-based supramolecular inclusion complex and a preparation method and use thereof. A supramolecular compound and a vulcanization accelerator DPG are subjected to supramolecular interaction to form a DPG-based supramolecular inclusion complex. While improving water solubility and dispersibility of the DPG, a molecular structure of the DPG can be completely retained, and the supramolecular host used does not affect a performance of latex. The supramolecular compound and the DPG are ball milled in a certain proportion to prepare the DPG-based supramolecular inclusion complex, the water-soluble DPG-based supramolecular inclusion complex is added in a natural latex curing process; and after mixing evenly, a mixture is foamed on-machine, vulcanized in a steamer, and dried to obtain a latex foam product. The latex product has significantly improved tensile strength and elongation at break, and reduced hardness, which is more healthy and hygienic, showing broad market prospects.

公开(公告)号：US12031008B2

公开(公告)日：2024-07-09

申请号：US18361981

申请日：2023-07-31

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Scott Zawko ,  Christine Schmidt

IPC: C08J9/26 ,  A61L26/00 ,  A61L27/52 ,  B01J13/00 ,  C08B37/00 ,  C08B37/08 ,  C08B37/16 ,  C08H1/06 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08J5/10 ,  C08J5/18 ,  C08K5/00 ,  C08K5/21 ,  C08L5/00 ,  C08L5/04 ,  C08L5/10 ,  C08L5/16 ,  C08L89/06 ,  C08J3/26

CPC classification number: C08J9/26 ,  A61L26/0023 ,  A61L26/0095 ,  A61L27/52 ,  B01J13/0065 ,  C08B37/0015 ,  C08B37/003 ,  C08B37/0045 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0084 ,  C08H1/06 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08J5/10 ,  C08J5/18 ,  C08K5/0025 ,  C08K5/0083 ,  C08K5/21 ,  C08L5/00 ,  C08L5/04 ,  C08L5/10 ,  C08L5/16 ,  C08L89/06 ,  C08J3/242 ,  C08J3/26 ,  C08J2201/0424 ,  C08J2205/022 ,  C08J2205/04 ,  C08J2207/10 ,  C08J2305/00 ,  C08J2305/04 ,  C08J2305/08 ,  C08L5/00 ,  C08K5/0025 ,  C08L5/06 ,  C08K5/0025 ,  C08L5/08 ,  C08K5/0025 ,  C08L5/04 ,  C08K5/0025 ,  C08L5/10 ,  C08K5/0025 ,  C08K5/0025 ,  C08L5/00 ,  C08K5/0025 ,  C08L5/06 ,  C08K5/0025 ,  C08L5/08 ,  C08K5/0025 ,  C08L5/04 ,  C08K5/0025 ,  C08L5/10

Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

公开(公告)号：US11965042B2

公开(公告)日：2024-04-23

申请号：US17970233

申请日：2022-10-20

Applicant: CycloPure, Inc.

Inventor： Gokhan Barin ,  Jason M. Spruell ,  Moira Brown ,  Shan Li

IPC: C08B31/00 ,  B01J20/26 ,  B01J20/28 ,  C02F1/28 ,  C08B37/16 ,  C08G18/76 ,  C08L5/16 ,  C02F101/36

CPC classification number: C08B31/006 ,  B01J20/267 ,  B01J20/28054 ,  C02F1/285 ,  C08B37/0012 ,  C08G18/7621 ,  C08L5/16 ,  B01J20/28057 ,  C02F2101/36 ,  C02F2303/04

Abstract: The present disclosure relates to charge-bearing polymeric materials and methods of their use for purifying fluid samples from micropollutants, such as anionic micropollutants.

公开(公告)号：US20240110014A1

公开(公告)日：2024-04-04

申请号：US18261018

申请日：2022-02-24

Applicant: Dow Silicones Corporation ,  Rohm and Haas Company

Inventor： Ryan Baumgartner ,  Shane Mangold ,  Zachary Wenzlick ,  Marc-Andre Courtemanche ,  Roxanne Haller ,  Michael Ferritto ,  Gregoire Cardoen

IPC: C08G77/42 ,  A61K8/73 ,  A61K8/89 ,  A61Q19/00 ,  C08G77/08 ,  C08G77/12 ,  C08L5/02 ,  C08L5/16

CPC classification number: C08G77/42 ,  A61K8/738 ,  A61K8/89 ,  A61Q19/00 ,  C08G77/08 ,  C08G77/12 ,  C08L5/02 ,  C08L5/16 ,  A61K2800/48 ,  A61K2800/95

Abstract: A composition includes a crosslinked polysiloxane elastomer with 2 or more carbon-oxygen-silicon linkages between a polysaccharide component and polysiloxane component, where the polysaccharide component is other than a cellulose or starch component.

公开(公告)号：US20230383086A1

公开(公告)日：2023-11-30

申请号：US18361981

申请日：2023-07-31

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Scott Zawko ,  Christine Schmidt

IPC: C08J9/26 ,  C08K5/00 ,  C08B37/08 ,  C08B37/00 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  B01J13/00 ,  C08B37/16 ,  C08H1/06 ,  C08L5/16 ,  C08L89/06 ,  A61L26/00 ,  A61L27/52 ,  C08J5/10 ,  C08J5/18 ,  C08K5/21 ,  C08L5/00 ,  C08L5/04 ,  C08L5/10

CPC classification number: C08J9/26 ,  C08K5/0025 ,  C08B37/0072 ,  C08B37/0084 ,  C08J3/075 ,  C08J3/24 ,  C08J3/28 ,  C08K5/0083 ,  B01J13/0065 ,  C08B37/0015 ,  C08B37/003 ,  C08B37/0045 ,  C08B37/0075 ,  C08H1/06 ,  C08L5/16 ,  C08L89/06 ,  A61L26/0023 ,  A61L26/0095 ,  A61L27/52 ,  C08J5/10 ,  C08J5/18 ,  C08K5/21 ,  C08L5/00 ,  C08L5/04 ,  C08L5/10 ,  C08J3/242 ,  C08J3/26

Abstract: The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.

公开(公告)号：US20230312887A1

公开(公告)日：2023-10-05

申请号：US18022570

申请日：2021-09-08

Applicant: Merck Sharp & Dohme LLC ,  Werthenstein BioPharma GMBH

Inventor： David J. Lamberto ,  Paolo Avalle ,  Lorenzo Codan ,  Patrick Larpent ,  Jochen Schoell ,  Jeffrey S. Neuhaus

IPC: C08L5/16 ,  C08B37/16

CPC classification number: C08L5/16 ,  C08B37/0012

Abstract: The present invention relates to a process for drying crystalline sugammadex to meet solvent specifications that is independent of API crystallinity or crystalline form generated. It further relates to use of sugammadex in the reversal of neuromuscular blockade induced by recuronium bromide or by vecuronium bromide in adults undergoing surgery.

公开(公告)号：US20230123626A1

公开(公告)日：2023-04-20

申请号：US17796216

申请日：2020-12-02

Applicant: TOYODA GOSEI CO., LTD. ,  THE UNIVERSITY OF TOKYO

Inventor： Takanori NAKAI ,  Naoki IWASE ,  Naoyuki AKAHORI ,  Hideyuki IMAI ,  Hidekazu KURIMOTO ,  Makoto ISHIDA ,  Kohzo ITO ,  Rina MAEDA ,  Shota ANDO ,  Katsunari INOUE

IPC: C08L5/16

Abstract: The present invention provides a crosslinked polymer composition exhibiting significantly improved elongation at break over conventional ones, and a polymer composition and a polyrotaxane, each of which can be used as a raw material of the crosslinked polymer composition.
The polyrotaxane contains a linear molecule, a cyclic molecule, and a blocking group, wherein the cyclic molecule has a hydrosilyl group. The polymer composition contains the polyrotaxane and a polymer, wherein the polymer has a double bond on at least either a main chain or a side chain. The crosslinked polymer composition is produced by crosslinking of the polymer composition through chemical reaction between the hydrosilyl group of the cyclic molecule and the double bond of the polymer.

公开(公告)号：US11571406B2

公开(公告)日：2023-02-07

申请号：US16951871

申请日：2020-11-18

Applicant: Pharmagra Labs, Inc.

Inventor： Sahadeva Reddy Damireddi ,  Kpakpo Ambrioise Akue ,  Jared K. Nelson ,  Albert Roger Frisbee ,  Peter Wyatt Newsome

IPC: C07C331/20 ,  C07C315/02 ,  A61K31/26 ,  A61K31/724 ,  C08L5/16 ,  B82Y5/00 ,  A61K47/69 ,  C08B37/16

Abstract: The present invention relates to a method of synthesising sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesising a stabilised complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.

公开(公告)号：US11491227B2

公开(公告)日：2022-11-08

申请号：US14379109

申请日：2013-02-20

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Oren Scherman ,  Eric Appel ,  Xian Jun Loh ,  Frank Biedermann ,  Matthew Rowland

IPC: A61K47/32 ,  A61K38/38 ,  A61K38/47 ,  C08L39/00 ,  C08J3/075 ,  C08B11/12 ,  C08G18/71 ,  C08L1/02 ,  C08B11/08 ,  C08J3/24 ,  C08B37/08 ,  C08L5/08 ,  C08L5/16 ,  C08L1/28 ,  C08G18/64 ,  C08B37/16

Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.