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公开(公告)号：US10000581B2
公开(公告)日：2018-06-19
申请号：US14889722
申请日：2014-05-07
IPC分类号： A61K8/00 , C08B37/16 , G01N33/68 , A61K31/724 , A61K31/765 , A61K47/48 , A61K51/06 , A61K51/12 , C08G83/00 , A61K47/54
CPC分类号： C08B37/0015 , A61K31/724 , A61K31/765 , A61K47/547 , A61K47/60 , A61K47/61 , A61K47/6951 , A61K51/065 , A61K51/1268 , C08G83/007 , G01N33/6893
摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.
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公开(公告)号：US11434330B2
公开(公告)日：2022-09-06
申请号：US15768365
申请日：2016-10-14
摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes of the various embodiments of the present invention.
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公开(公告)号：US20210041388A1
公开(公告)日：2021-02-11
申请号：US17075793
申请日：2020-10-21
IPC分类号： G01N27/12 , H01J37/20 , G01N1/30 , C01B32/192 , G01N27/414
摘要： Methods of using grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are disclosed. Said grid comprising a coating modified with one or more capture agents and a deactivating agent.
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公开(公告)号：US20190003999A1
公开(公告)日：2019-01-03
申请号：US16063029
申请日：2016-12-16
申请人： David H. Thompson , Christopher Benjamin , Kyle J. Wright , Scott C. Bolton , Seok-Hee Hyun , Purdue Research Foundation
IPC分类号： G01N27/12 , C01B32/192 , G01N27/414
摘要： Grids comprising a coating modified with one or more capture agents and a deactivating agent are disclosed. Methods of using such grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are also disclosed.
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公开(公告)号：US10118996B2
公开(公告)日：2018-11-06
申请号：US13774302
申请日：2013-02-22
发明人： David H. Thompson , Seok-Hee Hyun , Kyle J. Wright
摘要： A polyrotaxane containing an affinity binding group has been designed and prepared. The polyrotaxane of the invention can be used for characterization and determination of the three-dimensional structures of biological molecules, such as proteins.
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公开(公告)号：US09526802B2
公开(公告)日：2016-12-27
申请号：US14543386
申请日：2014-11-17
发明人： David H. Thompson , Aditya Kulkarni , Wei Deng
CPC分类号： A61K47/48969 , A61K31/713 , A61K47/6951 , A61K48/00 , C12N15/85 , C12N15/87 , C12N2710/10043
摘要： The invention relates to nucleic acid complexes, methods of preparation thereof, and uses thereof for delivering a nucleic acid into a cell.
摘要翻译： 本发明涉及核酸复合物，其制备方法及其用于将核酸递送至细胞中的用途。
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公开(公告)号：US20160083485A1
公开(公告)日：2016-03-24
申请号：US14889722
申请日：2014-05-07
IPC分类号： C08B37/16 , A61K47/48 , A61K51/12 , A61K51/06 , A61K31/765 , A61K31/724
CPC分类号： C08B37/0015 , A61K31/724 , A61K31/765 , A61K47/547 , A61K47/60 , A61K47/61 , A61K47/6951 , A61K51/065 , A61K51/1268 , C08G83/007 , G01N33/6893
摘要： Various embodiments of the present invention are directed to polyrotaxanes comprising a poloxamer core and at least one cyclodextrin and methods for treating Niemann-Pick type C (NPC) and imaging (e.g., MRI) using the polyrotaxanes various embodiments of the present invention.
摘要翻译： 本发明的各种实施方案涉及包含泊洛沙姆核心和至少一种环糊精的聚轮烷和使用本发明的各种实施方案使用聚轮烷成像（例如，MRI）的尼曼 - 皮克C型（NPC）的方法。
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公开(公告)号：US08916697B2
公开(公告)日：2014-12-23
申请号：US13826887
申请日：2013-03-14
发明人： David H. Thompson , Aditya Kulkarni , Wei Deng
CPC分类号： A61K47/48969 , A61K31/713 , A61K47/6951 , A61K48/00 , C12N15/85 , C12N15/87 , C12N2710/10043
摘要： The invention relates to nucleic acid complexes, methods of preparation thereof, and uses thereof for delivering a nucleic acid into a cell.
摘要翻译： 本发明涉及核酸复合物，其制备方法及其用于将核酸递送至细胞中的用途。
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公开(公告)号：US11965851B2
公开(公告)日：2024-04-23
申请号：US17075793
申请日：2020-10-21
IPC分类号： G01N27/12 , C01B32/192 , G01N1/30 , G01N27/414 , H01J37/20 , B82Y30/00 , B82Y40/00 , C07K1/14
CPC分类号： G01N27/127 , C01B32/192 , G01N1/30 , G01N27/4145 , H01J37/20 , B82Y30/00 , B82Y40/00 , C07K1/14 , G01N2223/418
摘要： Methods of using grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are disclosed. Said grid comprising a coating modified with one or more capture agents and a deactivating agent.
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公开(公告)号：US10989681B2
公开(公告)日：2021-04-27
申请号：US16063029
申请日：2016-12-16
IPC分类号： G01N27/12 , C01B32/192 , G01N27/414 , H01J37/20 , G01N1/30 , B82Y30/00 , B82Y40/00 , C07K1/14
摘要： Grids comprising a coating modified with one or more capture agents and a deactivating agent are disclosed. Methods of using such grids in connection with suitable microscopy techniques, such as for determining the structure of target compounds including proteins, are also disclosed.
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