公开(公告)号：US20230192601A1

公开(公告)日：2023-06-22

申请号：US17924865

申请日：2021-03-09

Applicant: Purdue Research Foundation

Inventor： David Harley Thompson ,  Zoltan Kalman Nagy ,  Ahmed Mufti ,  Jaron Mackey

IPC: C07C273/18

CPC classification number: C07C273/18

Abstract: The present disclosure provides processes and apparatuses for the scaled-up manufacture of lomustine via continuous flow manufacture. Such continuous flow processes may optionally include the crystallization of lomustine and the apparatuses may optionally include crystallization apparatuses/reactors in either batch or continuous flow design. In one aspect of the disclosure, a process for making lomustine is provided comprising treating solutions of 2-chloroethylisocyanate with a solution of cyclohexylamine with continuous-flow pumps in a gram-flow reactor to form a combined solution, adding deionized water with a continuous flow-pump to the combined solution to form a liquid-organic phase solution, extracting the organic phase from the solution and treating with a solution of t-butyl nitrite with a continuous flow pump in a gram flow reactor to form lomustine.