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    SCALED-UP SYNTHESIS OF LOMUSTINE UNDER CONTROL FLOW CONDITIONS
    1.
    发明公开
    SCALED-UP SYNTHESIS OF LOMUSTINE UNDER CONTROL FLOW CONDITIONS 审中-公开

    公开(公告)号：US20230192601A1

    公开(公告)日：2023-06-22

    申请号：US17924865

    申请日：2021-03-09

    Applicant: Purdue Research Foundation

    Inventor： David Harley Thompson ,  Zoltan Kalman Nagy ,  Ahmed Mufti ,  Jaron Mackey

    IPC: C07C273/18

    CPC classification number: C07C273/18

    Abstract: The present disclosure provides processes and apparatuses for the scaled-up manufacture of lomustine via continuous flow manufacture. Such continuous flow processes may optionally include the crystallization of lomustine and the apparatuses may optionally include crystallization apparatuses/reactors in either batch or continuous flow design. In one aspect of the disclosure, a process for making lomustine is provided comprising treating solutions of 2-chloroethylisocyanate with a solution of cyclohexylamine with continuous-flow pumps in a gram-flow reactor to form a combined solution, adding deionized water with a continuous flow-pump to the combined solution to form a liquid-organic phase solution, extracting the organic phase from the solution and treating with a solution of t-butyl nitrite with a continuous flow pump in a gram flow reactor to form lomustine.

    Systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer
    2.
    发明授权
    Systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer 有权

    公开(公告)号：US10766014B2

    公开(公告)日：2020-09-08

    申请号：US15496355

    申请日：2017-04-25

    Applicant: Purdue Research Foundation

    Inventor： Andy Koswara ,  Zoltan Kalman Nagy

    IPC: C30B29/54 ,  B01J19/00 ,  C07C227/42 ,  C07C231/24 ,  B08B7/00 ,  B08B17/00 ,  C30B7/08 ,  B01D9/00

    Abstract: The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel. In certain embodiments, these segments may be cyclically alternated, in that the segment in which crystal grows in one cycle becomes the segment in which crystal dissolves in the next cycle and vice versa, to realize a fully continuous crystallization process.

    Systems and methods for producing a chemical product
    6.
    发明授权
    Systems and methods for producing a chemical product 有权

    公开(公告)号：US10751685B2

    公开(公告)日：2020-08-25

    申请号：US16094091

    申请日：2017-04-24

    Applicant: Purdue Research Foundation

    Inventor： Andy Koswara ,  Zoltan Kalman Nagy ,  Conor Douglas Parks

    IPC: B01J19/00 ,  C07C213/06 ,  C07D207/16

    Abstract: The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

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