公开(公告)号：US11061035B2

公开(公告)日：2021-07-13

申请号：US16071347

申请日：2017-01-20

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

IPC: G01N33/531 ,  G01N33/532 ,  G01N30/72 ,  G01N33/68 ,  G01N33/574

Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

公开(公告)号：US12055550B2

公开(公告)日：2024-08-06

申请号：US17342804

申请日：2021-06-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

IPC: G01N33/68 ,  G01N33/531 ,  G01N33/574

CPC classification number: G01N33/6848 ,  G01N33/531 ,  G01N33/5748 ,  G01N33/574 ,  G01N2560/00

Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

公开(公告)号：US20210293826A1

公开(公告)日：2021-09-23

申请号：US17342804

申请日：2021-06-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

IPC: G01N33/68 ,  G01N33/531 ,  G01N33/574

Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

公开(公告)号：US20240393346A1

公开(公告)日：2024-11-28

申请号：US18750036

申请日：2024-06-21

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

IPC: G01N33/68 ,  G01N33/531 ,  G01N33/574

Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

公开(公告)号：US20190128897A1

公开(公告)日：2019-05-02

申请号：US16071347

申请日：2017-01-20

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

IPC: G01N33/68 ,  G01N33/574

Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.