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    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES
    1.
    发明申请
    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES 有权

    公开(公告)号：US20230115304A1

    公开(公告)日：2023-04-13

    申请号：US18075578

    申请日：2022-12-06

    Applicant: Purdue Research Foundation

    Inventor： Zane Baird ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    CHARGED MASS LABELING SYSTEM
    3.
    发明申请
    CHARGED MASS LABELING SYSTEM 有权

    公开(公告)号：US20240393346A1

    公开(公告)日：2024-11-28

    申请号：US18750036

    申请日：2024-06-21

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

    IPC: G01N33/68 ,  G01N33/531 ,  G01N33/574

    Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

    CHARGED MASS LABELING SYSTEM
    4.
    发明申请
    CHARGED MASS LABELING SYSTEM 审中-公开

    公开(公告)号：US20190128897A1

    公开(公告)日：2019-05-02

    申请号：US16071347

    申请日：2017-01-20

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

    IPC: G01N33/68 ,  G01N33/574

    Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

    Mass tag analysis for rare cells and cell free molecules
    6.
    发明授权
    Mass tag analysis for rare cells and cell free molecules 有权

    公开(公告)号：US11531024B2

    公开(公告)日：2022-12-20

    申请号：US15762597

    申请日：2016-09-24

    Applicant: Purdue Research Foundation

    Inventor： Zane Baird ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

    CHARGED MASS LABELING SYSTEM
    7.
    发明申请
    CHARGED MASS LABELING SYSTEM 有权

    公开(公告)号：US20210293826A1

    公开(公告)日：2021-09-23

    申请号：US17342804

    申请日：2021-06-09

    Applicant: Purdue Research Foundation

    Inventor： Robert Graham Cooks ,  Zane Baird ,  Michael Pugia ,  Adam Hollerbach ,  Stephen Ayrton

    IPC: G01N33/68 ,  G01N33/531 ,  G01N33/574

    Abstract: The invention generally relates to charged mass label compositions and methods of use thereof for detecting a target analyte in a sample. In certain aspects, the invention provides a charged mass label composition including an affinity reagent, and a mass label precursor bound to the affinity reagent. The mass label precursor includes a label binding unit and a mass label. The label binding unit reversibly binds the mass label to the affinity reagent. The mass label includes a charge unit and a mass label unit having a pre-defined mass-to-charge-value in a mass spectrum.

    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES
    8.
    发明申请
    MASS TAG ANALYSIS FOR RARE CELLS AND CELL FREE MOLECULES 审中-公开

    公开(公告)号：US20180275118A1

    公开(公告)日：2018-09-27

    申请号：US15762597

    申请日：2016-09-24

    Applicant: Purdue Research Foundation

    Inventor： Baird Zane ,  Robert Graham Cooks ,  Adam Hollerbach ,  Zheng Ouyang ,  Michael Pugia

    IPC: G01N33/53

    CPC classification number: G01N33/5302 ,  G01N2458/15

    Abstract: The invention generally relates to mass tag analysis for rare cells and cell free molecules. In certain embodiments, the invention provides an apparatus including an essentially non-absorbent membrane having at least one pore, a microwell operably associated with the essentially non-absorbent membrane, and an electric field generator. The apparatus may be configured such that an electric field produced by the electric field generator operably interacts with a sample in the microwell and expels a droplet of the sample through the at least one pore in the essentially non-absorbent membrane. In certain embodiments, apparatuses of the invention are used for detection, and optionally quantification, of a target analyte from a heterogeneous sample, such as a rare target analyte (e.g., rare cell) from a biological sample.

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