公开(公告)号：US11273447B2

公开(公告)日：2022-03-15

申请号：US16741222

申请日：2020-01-13

Applicant: Purdue Research Foundation

Inventor： Bumsoo Han ,  George Tsu-Chih Chiu ,  Thomas Heinrich Siegmund ,  Michael Linnes ,  Yumeng Wu ,  Matthew Tyler Short

IPC: C12M3/00 ,  C12M1/00 ,  B01L3/00

Abstract: Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.