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    Collapsible basket arrays, collapsible cellular arrays therefor, and methods of use
    1.
    发明授权
    Collapsible basket arrays, collapsible cellular arrays therefor, and methods of use 有权

    公开(公告)号：US11273447B2

    公开(公告)日：2022-03-15

    申请号：US16741222

    申请日：2020-01-13

    Applicant: Purdue Research Foundation

    Inventor： Bumsoo Han ,  George Tsu-Chih Chiu ,  Thomas Heinrich Siegmund ,  Michael Linnes ,  Yumeng Wu ,  Matthew Tyler Short

    IPC: C12M3/00 ,  C12M1/00 ,  B01L3/00

    Abstract: Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.

    COLLAPSIBLE BASKET ARRAYS, COLLAPSIBLE CELLULAR ARRAYS THEREFOR, AND METHODS OF USE
    2.
    发明申请
    COLLAPSIBLE BASKET ARRAYS, COLLAPSIBLE CELLULAR ARRAYS THEREFOR, AND METHODS OF USE 审中-公开

    公开(公告)号：US20200222898A1

    公开(公告)日：2020-07-16

    申请号：US16741222

    申请日：2020-01-13

    Applicant: Purdue Research Foundation

    Inventor： Bumsoo Han ,  George Tsu-Chih Chiu ,  Thomas Heinrich Siegmund ,  Michael Linnes ,  Yument Wu ,  Matthew Tyler Short

    IPC: B01L3/00 ,  C12M1/00 ,  C12M3/00

    Abstract: Multi-well collapsible basket arrays and methods for their use with high throughput culture and histology analysis of spheroids and organoids. Such a collapsible basket array includes a collapsible cellular array structure having multiple cells and connectors that interconnect adjacent pairs of the cells to cause the collapsible cellular array structure to collapse from an expanded configuration to a collapsed configuration in which the connectors are partially wrapped around perimeters or circumferences of the cells, whereby the collapsible cellular array structure is expandable to acquire an expanded configuration capable of individually aligning the cells thereof with wells of a well plate. The collapsible basket array further includes inserts individually mountable to the cells of the collapsible cellular array structure, with each insert including a permeable basket with pores sized to retain spheroids or organoids within the basket.

    Method of detecting a substance
    6.
    发明授权
    Method of detecting a substance 有权

    公开(公告)号：US10948489B2

    公开(公告)日：2021-03-16

    申请号：US16040504

    申请日：2018-07-19

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  Eric A. Nauman ,  Mackenzie Tweardy ,  Michael Wadas ,  Allison Kelly Murray ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N33/543 ,  G01N33/547 ,  C07K16/18 ,  C08L25/06

    Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte. Moreover the method includes determining a difference between a first resonant frequency shift in the first set of sensors of the plurality of sensors and a second resonant frequency shift in the second set of sensors of the plurality of sensors.

    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK
    8.
    发明申请
    NONLINEAR MASS SENSORS BASED ON ELECTRONIC FEEDBACK 审中-公开

    公开(公告)号：US20200064310A1

    公开(公告)日：2020-02-27

    申请号：US16333273

    申请日：2018-12-04

    Applicant: Purdue Research Foundation

    Inventor： Jeffrey Frederick Rhoads ,  George Tsu-Chih Chiu ,  Nikhil Bajaj

    IPC: G01N29/12

    Abstract: This present disclosure relates to sensors capable of sensing mass, stiffness, and chemical or biological substances. More specifically, this disclosure provides the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates around at least 1 MHz.

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