公开(公告)号：US10760068B2

公开(公告)日：2020-09-01

申请号：US16320164

申请日：2017-07-20

申请人： QGEL SA

发明人： Simone Rizzi ,  Jeremy Touati

IPC分类号： C12N9/74 ,  C12N5/00

摘要： A hydrogel precursor formulation which is in the form of an unreacted powder. The formulation comprises an activating enzyme, preferably thrombin, a cross-linking enzyme, preferably a transglutaminase, and more preferably factor XIII transglutaminase. The cross-linking enzyme is activatable by the activating enzyme in water with or without a buffer, and at least one structural compound A. The structural compound is crosslinkable by a selective reaction mediated by the crosslinking enzyme to form a hydrogel, wherein the cross-linking enzyme is activated.