公开(公告)号：US20150299263A1

公开(公告)日：2015-10-22

申请号：US14646860

申请日：2013-11-21

Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

Inventor： Abhishek Kashyap ,  Gary Keith Shooter ,  David Leavesley ,  Brett Hollier ,  Adrian Charles Herington ,  Zee Upton

IPC: C07K9/00 ,  A61K45/06 ,  A61K38/14

CPC classification number: C07K9/00 ,  A61K38/00 ,  A61K38/14 ,  A61K45/06 ,  C07K14/72

Abstract: Disclosed are methods and agents for modulating proliferation, migration and/or survival of cells. More particularly, the present invention discloses molecules that have any one or more activities selected from: inhibiting binding of vitronectin to at least one vitronectin-binding partner selected from an IGF and IGFBP, inhibiting formation of a complex comprising vitronectin and at least one vitronectin-binding partner selected from an IGF and IGFBP, or inhibiting proliferation or survival of a hyperproliferative cell (e.g., a neoplastic cell or non-neoplastic cell), or inhibiting migration or invasion of a hyperproliferative cell (e.g., a neoplastic cell or a non-neoplastic cell). Additionally, the present invention discloses the use of these molecules in methods and compositions for treating or preventing hyperproliferative cell disorders including neoplastic (e.g., cancers such as epithelial cancers) and non-neoplastic disorders.

Abstract translation: 公开了用于调节细胞增殖，迁移和/或存活的方法和试剂。 更具体地，本发明公开了具有任何一种或多种活性的分子，所述活性选自：抑制玻连蛋白与选自IGF和IGFBP的至少一种玻连蛋白结合配偶体的结合，抑制形成包含玻连蛋白和至少一种玻连蛋白 - 选自IGF和IGFBP的结合配偶体，或抑制过度增殖细胞（例如，肿瘤细胞或非肿瘤细胞）的增殖或存活，或抑制过度增殖细胞（例如肿瘤细胞或非肿瘤细胞）的迁移或侵袭， 肿瘤细胞）。 此外，本发明公开了这些分子在用于治疗或预防过度增殖性细胞病症（包括肿瘤（例如癌症如上皮癌））和非肿瘤性疾病的方法和组合物中的用途。