公开(公告)号：US08933027B2

公开(公告)日：2015-01-13

申请号：US14032848

申请日：2013-09-20

Applicant: Queensland University of Technology

Inventor： Zee Upton ,  Jennifer Ann Kricker

IPC: A61K38/30 ,  A61K38/39 ,  A61P35/00 ,  C07K14/65 ,  A61K47/48 ,  A61K38/17 ,  C07K14/71 ,  C07K14/78

CPC classification number: A61K47/48246 ,  A61K38/1709 ,  A61K38/30 ,  A61K38/39 ,  C07K14/71 ,  C07K14/78 ,  A61K2300/00

Abstract: A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an agent which disrupts an isolated protein complex including: insulin-like growth factor I (IGF-I); an insulin-like growth factor binding protein (IGFBP) selected from IGFBP-3 and IGFBP-5; and vitronectin; or which prevents formation of the isolated protein complex, to thereby treat the disease or condition in the mammal. The agent is selected from the group consisting a polypeptide that is distinguished from IGF-II by substitution of at least one amino acid residue, wherein the polypeptide disrupts the isolated protein complex.

Abstract translation: 提供了一种治疗以异常上皮细胞增殖和/或迁移为特征的疾病或病症的方法。 该方法的一个步骤可以包括向哺乳动物施用破坏分离的蛋白质复合物的试剂，包括：胰岛素样生长因子I（IGF-I）; 选自IGFBP-3和IGFBP-5的胰岛素样生长因子结合蛋白（IGFBP）; 和玻连蛋白; 或其防止分离的蛋白质复合物的形成，从而治疗哺乳动物的疾病或病症。 所述试剂选自通过至少一个氨基酸残基的取代与IGF-II区分的多肽，其中多肽破坏分离的蛋白质复合物。

公开(公告)号：US20150299263A1

公开(公告)日：2015-10-22

申请号：US14646860

申请日：2013-11-21

Applicant: QUEENSLAND UNIVERSITY OF TECHNOLOGY

Inventor： Abhishek Kashyap ,  Gary Keith Shooter ,  David Leavesley ,  Brett Hollier ,  Adrian Charles Herington ,  Zee Upton

IPC: C07K9/00 ,  A61K45/06 ,  A61K38/14

CPC classification number: C07K9/00 ,  A61K38/00 ,  A61K38/14 ,  A61K45/06 ,  C07K14/72

Abstract: Disclosed are methods and agents for modulating proliferation, migration and/or survival of cells. More particularly, the present invention discloses molecules that have any one or more activities selected from: inhibiting binding of vitronectin to at least one vitronectin-binding partner selected from an IGF and IGFBP, inhibiting formation of a complex comprising vitronectin and at least one vitronectin-binding partner selected from an IGF and IGFBP, or inhibiting proliferation or survival of a hyperproliferative cell (e.g., a neoplastic cell or non-neoplastic cell), or inhibiting migration or invasion of a hyperproliferative cell (e.g., a neoplastic cell or a non-neoplastic cell). Additionally, the present invention discloses the use of these molecules in methods and compositions for treating or preventing hyperproliferative cell disorders including neoplastic (e.g., cancers such as epithelial cancers) and non-neoplastic disorders.

Abstract translation: 公开了用于调节细胞增殖，迁移和/或存活的方法和试剂。 更具体地，本发明公开了具有任何一种或多种活性的分子，所述活性选自：抑制玻连蛋白与选自IGF和IGFBP的至少一种玻连蛋白结合配偶体的结合，抑制形成包含玻连蛋白和至少一种玻连蛋白 - 选自IGF和IGFBP的结合配偶体，或抑制过度增殖细胞（例如，肿瘤细胞或非肿瘤细胞）的增殖或存活，或抑制过度增殖细胞（例如肿瘤细胞或非肿瘤细胞）的迁移或侵袭， 肿瘤细胞）。 此外，本发明公开了这些分子在用于治疗或预防过度增殖性细胞病症（包括肿瘤（例如癌症如上皮癌））和非肿瘤性疾病的方法和组合物中的用途。

公开(公告)号：US20140045749A1

公开(公告)日：2014-02-13

申请号：US14032848

申请日：2013-09-20

Applicant: Queensland University of Technology

Inventor： Zee Upton ,  Jennifer Ann Kricker

IPC: A61K47/48

CPC classification number: A61K47/48246 ,  A61K38/1709 ,  A61K38/30 ,  A61K38/39 ,  C07K14/71 ,  C07K14/78 ,  A61K2300/00

Abstract: A method is provided for treating a disease or condition characterized by aberrant epithelial cell proliferation and/or migration. One step of the method can include administering to a mammal an agent which disrupts an isolated protein complex including: insulin-like growth factor I (IGF-I); an insulin-like growth factor binding protein (IGFBP) selected from IGFBP-3 and IGFBP-5; and vitronectin; or which prevents formation of the isolated protein complex, to thereby treat the disease or condition in the mammal. The agent is selected from the group consisting a polypeptide that is distinguished from IGF-II by substitution of at least one amino acid residue, wherein the polypeptide disrupts the isolated protein complex.

Abstract translation: 提供了一种治疗以异常上皮细胞增殖和/或迁移为特征的疾病或病症的方法。 该方法的一个步骤可以包括向哺乳动物施用破坏分离的蛋白质复合物的试剂，包括：胰岛素样生长因子I（IGF-I）; 选自IGFBP-3和IGFBP-5的胰岛素样生长因子结合蛋白（IGFBP）; 和玻连蛋白; 或其防止分离的蛋白质复合物的形成，从而治疗哺乳动物的疾病或病症。 所述试剂选自通过至少一个氨基酸残基的取代与IGF-II区分的多肽，其中多肽破坏分离的蛋白质复合物。