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    Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
    1.
    发明授权
    Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors 有权
    鉴定游离B环类黄酮作为有效的COX-2抑制剂

    公开(公告)号：US07192611B2

    公开(公告)日：2007-03-20

    申请号：US10469275

    申请日：2003-02-28

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    IPC分类号： A01N65/00

    CPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K36/18

    摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供抑制环加氧酶COX-2的新方法。 该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。 本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。 预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物 和药学上可接受的载体。

    Identification of free-B-ring flavonoids as potent COX-2 inhibitors
    2.
    发明授权
    Identification of free-B-ring flavonoids as potent COX-2 inhibitors 有权
    鉴定游离B环类黄酮作为有效的COX-2抑制剂

    公开(公告)号：US08535735B2

    公开(公告)日：2013-09-17

    申请号：US13493820

    申请日：2012-06-11

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    IPC分类号： A01N65/00

    CPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K36/539

    摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供抑制环加氧酶COX-2的新方法。 该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。 本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。 预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物 和药学上可接受的载体。

    Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia
    3.
    发明授权
    Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia 有权
    从阿拉伯胶中分离双重COX-2和5-脂氧合酶抑制剂

    公开(公告)号：US08568799B2

    公开(公告)日：2013-10-29

    申请号：US13355362

    申请日：2012-01-20

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    IPC分类号： A01N65/00

    CPC分类号： A61K31/353 ,  A61K31/33 ,  A61K36/00 ,  A61K36/48

    摘要： The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.

    摘要翻译： 本公开提供了用于减轻炎症相关疾病和病症的组合物和方法。 这些方法包括给予分离自植物单个或多个相思树属的多种黄烷的个体和/或混合物。 本公开还包括从植物相思属分离和纯化具有环氧合酶（COX-2）和5-脂肪氧合酶（5-LO）酶的双重特异性的黄酮组合物的方法。

    IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS
    4.
    发明申请
    IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS 有权
    作为COCO-2抑制剂的自由B环氟虫酯的鉴定

    公开(公告)号：US20130012463A1

    公开(公告)日：2013-01-10

    申请号：US13493820

    申请日：2012-06-11

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    IPC分类号： A61K31/352 ,  A61P19/02 ,  A61P29/00 ,  A61K31/7048

    CPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K36/539

    摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供抑制环加氧酶COX-2的新方法。 该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。 本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。 预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物 和药学上可接受的载体。

    ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA
    5.
    发明申请
    ISOLATION OF A DUAL COX-2 AND 5-LIPOXYGENASE INHIBITOR FROM ACACIA 有权
    从ACACIA分离双COX-2和5-LIPOXYGENASE抑制剂

    公开(公告)号：US20120329863A1

    公开(公告)日：2012-12-27

    申请号：US13355362

    申请日：2012-01-20

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Waite

    IPC分类号： A61K31/353 ,  A61P25/00

    CPC分类号： A61K31/353 ,  A61K31/33 ,  A61K36/00 ,  A61K36/48

    摘要： The present disclosure provides compositions and methods for alleviating inflammatory-associated diseases and conditions. These methods include administering individual and/or a mixture of multiple flavans isolated from a single or multiple Acacia genus of plants. The present disclosure also includes methods for isolating and purifying from an Acacia genus of plants a composition of flavans having dual specificity for cyclooxygenase (COX-2) and 5-lipoxygenase (5-LO) enzymes.

    摘要翻译： 本公开提供了用于减轻炎症相关疾病和病症的组合物和方法。 这些方法包括给予分离自植物单个或多个相思树属的多种黄烷的个体和/或混合物。 本公开还包括从植物相思属分离和纯化具有环氧合酶（COX-2）和5-脂肪氧合酶（5-LO）酶的双重特异性的黄酮组合物的方法。

    IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS
    6.
    发明申请
    IDENTIFICATION OF FREE-B-RING FLAVONOIDS AS POTENT COX-2 INHIBITORS 审中-公开
    作为COCO-2抑制剂的自由B环氟虫酯的鉴定

    公开(公告)号：US20110245333A1

    公开(公告)日：2011-10-06

    申请号：US13084419

    申请日：2011-04-11

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Walte

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric E. Rhoden ,  Scott Walte

    IPC分类号： A61K31/352 ,  A61P29/00

    CPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K36/539

    摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供抑制环加氧酶COX-2的新方法。 该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。 本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。 预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物 和药学上可接受的载体。

    Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia
    7.
    发明授权
    Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia 有权
    从相思树中分离双重COX-2和5-脂氧合酶抑制剂

    公开(公告)号：US08124134B2

    公开(公告)日：2012-02-28

    申请号：US11457388

    申请日：2006-07-13

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric Rhoden ,  Scott Waite

    IPC分类号： A01N65/00

    CPC分类号： A61K31/353 ,  A61K31/33 ,  A61K36/00 ,  A61K36/48

    摘要： The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.

    摘要翻译： 本发明提供了同时抑制环氧合酶COX-2和5-脂氧合酶（5-LO）酶的新方法。 同时双重抑制COX-2和5-LO的方法包括将含有单个植物或多种植物的多种黄烷的个体和/或混合物的组合物施用于植物相思树属植物中的宿主 需要。 本发明还包括预防和治疗COX-2和5-LO介导的疾病和病症的新方法。 预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，其包含从单一植物分离的个体和/或多种黄烷的混合物或 植物相思树属植物多种植物和药学上可接受的载体。 本发明包括分离和纯化来自植物相思树属的COX-2和5-LO双重特异性的黄烷组合物的方法。

    Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
    8.
    发明授权
    Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia 有权
    从阿拉伯胶中分离双重cox-2和5-脂氧合酶抑制剂

    公开(公告)号：US07108868B2

    公开(公告)日：2006-09-19

    申请号：US10104477

    申请日：2002-03-22

    申请人： Qi Jia ,  Timothy C. Nichols ,  Eric Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy C. Nichols ,  Eric Rhoden ,  Scott Waite

    IPC分类号： A61K36/00

    CPC分类号： A61K31/353 ,  A61K31/33 ,  A61K36/00 ,  A61K36/48

    摘要： The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.

    摘要翻译： 本发明提供了同时抑制环氧合酶COX-2和5-脂氧合酶（5-LO）酶的新方法。 同时双重抑制COX-2和5-LO的方法包括将含有单个植物或多种植物的多种黄烷的个体和/或混合物的组合物施用于植物相思树属植物中的宿主 需要。 本发明还包括预防和治疗COX-2和5-LO介导的疾病和病症的新方法。 预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，其包含从单一植物分离的个体和/或多种黄烷的混合物或 植物相思树属植物多种植物和药学上可接受的载体。 本发明包括分离和纯化来自植物相思树属的COX-2和5-LO双重特异性的黄烷组合物的方法。

    Isolation of a Dual Cox-2 and 5-Lipoxygenase Inhibitor from Acacia
    9.
    发明申请
    Isolation of a Dual Cox-2 and 5-Lipoxygenase Inhibitor from Acacia 有权
    从相思中分离双重Cox-2和5-脂氧合酶抑制剂

    公开(公告)号：US20060269627A1

    公开(公告)日：2006-11-30

    申请号：US11457388

    申请日：2006-07-13

    申请人： Qi Jia ,  Timothy Nichols ,  Eric Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy Nichols ,  Eric Rhoden ,  Scott Waite

    IPC分类号： A61K36/48

    CPC分类号： A61K31/353 ,  A61K31/33 ,  A61K36/00 ,  A61K36/48

    摘要： The present invention provides a novel method for simultaneously inhibiting the cyclooxygenase COX-2 and 5-lipoxygenase (5-LO) enzymes. The method for the simultaneous dual inhibition of COX-2 and 5-LO is comprised of administering a composition containing an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 and 5-LO mediated diseases and conditions. The method for preventing and treating COX-2 and 5-LO mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition comprising an individual and/or a mixture of multiple flavans isolated from a single plant or multiple plants in the Acacia genus of plants and a pharmaceutically acceptable carrier. The present invention includes a method for isolating and purifying a composition of flavans having dual specificity for COX-2 and 5-LO from the Acacia genus of plants.

    摘要翻译： 本发明提供了同时抑制环氧合酶COX-2和5-脂氧合酶（5-LO）酶的新方法。 同时双重抑制COX-2和5-LO的方法包括将含有单个植物或多种植物的多种黄烷的个体和/或混合物的组合物施用于植物相思树属植物中的宿主 需要。 本发明还包括预防和治疗COX-2和5-LO介导的疾病和病症的新方法。 预防和治疗COX-2和5-LO介导的疾病和病症的方法包括向有需要的宿主施用有效量的组合物，其包含从单一植物分离的个体和/或多种黄烷的混合物或 植物相思树属植物多种植物和药学上可接受的载体。 本发明包括分离和纯化来自植物相思树属的COX-2和5-LO双重特异性的黄烷组合物的方法。

    Identification of Free-B-Ring Flavonoids as Potent COX-2 Inhibitors
    10.
    发明申请
    Identification of Free-B-Ring Flavonoids as Potent COX-2 Inhibitors 有权
    鉴定游离B环类黄酮作为强效COX-2抑制剂

    公开(公告)号：US20070135359A1

    公开(公告)日：2007-06-14

    申请号：US11676528

    申请日：2007-02-20

    申请人： Qi Jia ,  Timothy Nichols ,  Eric Rhoden ,  Scott Waite

    发明人： Qi Jia ,  Timothy Nichols ,  Eric Rhoden ,  Scott Waite

    IPC分类号： A61K31/7048 ,  A61K31/353

    CPC分类号： A61K31/7048 ,  A61K31/353 ,  A61K36/539

    摘要： The present invention provides a novel method for inhibiting the cyclooxygenase enzyme COX-2. The method is comprised of administering a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids to a host in need thereof. The present also includes novel methods for the prevention and treatment of COX-2 mediated diseases and conditions. The method for preventing and treating COX-2 mediated diseases and conditions is comprised of administering to a host in need thereof an effective amount of a composition containing a Free-B-Ring flavonoid or a composition containing a mixture of Free-B-Ring flavonoids and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供抑制环加氧酶COX-2的新方法。 该方法包括向含有需要的宿主施用含有游离B环类黄酮或含有游离B环类黄酮的混合物的组合物的组合物。 本发明还包括预防和治疗COX-2介导的疾病和病症的新方法。 预防和治疗COX-2介导的疾病和病症的方法包括向有需要的宿主施用有效量的含有游离B环类黄酮或含有游离B环类黄酮混合物的组合物 和药学上可接受的载体。